General: anatomy embryology cytology histology molecular testing in FNA physiology recommended books ultrasound

Congenital / metabolic anomalies: aplasia/hypoplasia branchial pouch/cleft anomalies DiGeorge syndrome ectopic thyroid tissue lateral aberrant thyroid thyroid inclusions in lymph nodes lymphoepithelial cyst lysosomal storage diseases parasitic nodule parathyroid tissue solid cell nests thymic tissue thyroglossal duct/cyst thyroglossal duct carcinoma

Endocrine abnormalities: amiodarone congenital hypothyroidism hyperthyroidism hypothyroidism

Thyroiditis: acute / infectious autoimmune focal lymphocytic Hashimoto fibrosing Hashimoto lithium palpation postoperative granuloma postpartum radiation Riedel SARS silent subacute

Bethesda system: diagnostic categories adequacy nondiagnostic / unsatisfactory benign atypia of undetermined significance follicular neoplasm suspicious for malignancy malignant

Hyperplasia / goiter: amyloid goiter C cell hyperplasia dyshormonogenetic goiter endemic goiter Graves disease multinodular goiter solitary papillary hyperplastic nodule toxic goiter

Other nonneoplastic: black / pigmented thyroid calcification clear cell change crystals FNA tissue effects Killian-Jamieson diverticulum malakoplakia plasma cell granuloma sarcoidosis teflon

Benign neoplasms: adenolipoma follicular adenoma hyalinizing trabecular tumor lymphangioma paraganglioma postoperative spindle cell nodule rhabdomyoma Rosai-Dorfman disease solitary fibrous tumor solitary thyroid nodule

Thyroid cancer: general WHO classification molecular pathology-basics molecular pathology-practical children

Papillary thyroid carcinoma: general cytology
main variants: classic (pending) cribriform-morular diffuse sclerosing encapsulated microcarcinoma tall cell
follicular patterned: follicular encapsulated follicular invasive EFVPTC NIFTP diffuse follicular macrofollicular
rare variants: columnar cell fibromatosis/fasciitis-like hobnail oncocytic solid Warthin-like

Other thyroid carcinoma: main: anaplastic follicular medullary oncocytic (Hurthle cell) tumors poorly differentiated
rare: CASTLE MASC mixed medullary-follicular tumors mucoepidermoid sclerosing mucoepidermoid with eosinophilia secondary tumors / metastases SETTLE squamous cell well differentiated NOS WDT-UMP

Other malignancies: angiosarcoma hemangiopericytoma Langerhans cell histiocytosis lymphoma neuroblastoma plasmacytoma sarcoma teratoma

Miscellaneous: features to report frozen section grossing staging

Commonly used immunostains: calcitonin CK19 Galectin3 HBME thyroglobulin TTF1

Additional immunostains: AE1/AE3 BCL2 beta-catenin BRAF CD5 CD117 CEA chromogranin Congo Red Ki67 mammaglobin p53 p63 PAS PAX8 PTEN

Superpages: entire chapter images virtual slides


Index (Alphabetical table of contents)
A-E: acute thyroiditis adenolipoma amiodarone induced hyperthyroidism amyloid goiter anaplastic carcinoma anatomy angiosarcoma aplasia/hypoplasia autoimmune thyroiditis Bethesda systems: adequacy Bethesda systems: atypia of undetermined significance Bethesda systems: benign Bethesda systems: diagnostic categories Bethesda systems: follicular neoplasm Bethesda systems: malignant Bethesda systems: nondiagnostic / unsatisfactory Bethesda systems: suspicious for malignancy black / pigmented thyroid branchial pouch/cleft anomalies C cell hyperplasia calcification CASTLE clear cell change columnar cell variant of PTC congenital hypothyroidism cribriform-morular variant of PTC crystals cytology diffuse follicular variant of PTC diffuse sclerosing variant of PTC DiGeorge syndrome dyshormonogenetic goiter ectopic thyroid tissue embryology encapsulated follicular variant of PTC encapsulated variant of PTC endemic goiter

F-N: fibromatosis/fasciitis-like variant of PTC features to report fibrosing Hashimoto FNA tissue effects focal lymphocytic thyroiditis follicular adenoma follicular carcinoma follicular variant of PTC frozen section Graves disease grossing Hashimoto thyroiditis hemangiopericytoma histology hyalinizing trabecular tumor hyperthyroidism hypothyroidism infectious thyroiditis poorly differentiated carcinoma invasive EFVPTC Killian-Jamieson diverticulum Langerhans cell histiocytosis lateral aberrant thyroid lithium thyroiditis lymphangioma lymphoepithelial cyst lymphoma lysosomal storage diseases macrofollicular variant of PTC malakoplakia MASC medullary carcinoma microcarcinoma variant of PTC mixed medullary-follicular tumors molecular pathology-basics molecular pathology-practical molecular testing in FNA mucoepidermoid carcinoma multinodular goiter neuroblastoma NIFTP

O-Z: oncocytic (Hurthle cell) tumors oncocytic variant of PTC palpation thyroiditis papillary thyroid carcinoma-cytology papillary thyroid carcinoma - general papillary thyroid carcinoma - hobnail variant paraganglioma parasitic nodule parathyroid tissue physiology plasma cell granuloma plasmacytoma postoperative spindle cell nodule postoperative granuloma postpartum thyroiditis radiation thyroiditis recommended books rhabdomyoma Riedel thyroiditis Rosai-Dorfman disease sarcoidosis sarcoma SARS thyroiditis sclerosing mucoepidermoid carcinoma with eosinophilia secondary tumors / metastases SETTLE silent thyroiditis solid cell nests solid variant of PTC solitary fibrous tumor solitary papillary hyperplastic nodule solitary thyroid nodule squamous cell carcinoma staging subacute thyroiditis tall cell variant of PTC teflon in thyroid teratoma thymic tissue thyroglossal duct/cyst thyroglossal duct carcinoma thyroid cancer-children thyroid cancer-general thyroid inclusions in lymph nodes toxic goiter ultrasound Warthin-like variant of PTC well differentiated carcinoma NOS WDT-UMP WHO classification of thyroid cancer