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Skin nonmelanocytic tumor

Last staff update: 8 May 2023

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Related chapters: Skin melanocytic tumor, Skin nontumor, Soft tissue

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Table of contents
General:books staging-Merkel cell carcinoma staging-nonmelanocytic carcinoma WHO classification (pending)
Benign (nonmelanotic) epidermal tumors or tumor-like lesions:acanthoma fissuratum (pending) clear cell acanthoma clear cell papulosis dermatosis papulosa nigra epidermal nevus epidermolytic acanthoma ILVEN (pending) inverted follicular keratosis large cell acanthoma melanoacanthoma nevus comedonicus (pending) nevus with “skyline” basal celllayer (PENS) (pending) porokeratosis pseudocarcinomatous hyperplasia (pending) seborrheic keratosis warty dyskeratoma
Fibrous, fibrohistiocytic and myofibroblastic neoplasms:acquired digital fibrokeratoma angiofibroma / fibrous papule angiomatoid fibrous histiocytoma atypical fibroxanthoma collagenous fibroma dermatofibroma (cutaneous fibrous histiocytoma) dermatomyofibroma cutaneous fibroepithelial polyps keloid multinucleate cell angiohistiocytoma myoepithelioma pleomorphic dermal sarcoma pleomorphic fibroma sclerotic fibroma superficial angiomyxoma
Cysts:cystic / cavernous lymphangioma dermoid cyst digital myxoid cyst (pending) dilated pore of Winer (pending) epidermal (epidermoid) type hidrocystoma other cysts proliferating pilar tumor steatocystoma synovial cysts trichilemmal (pilar) type vellus hair cyst
Adnexal tumors
Sweat gland derived (apocrine & eccrine glands):adenoid cystic carcinoma (primary cutaneous) apocrine tubular adenoma cutaneous mixed tumor / chondroid syringoma cylindroma digital papillary adenocarcinoma eccrine spiradenoma eccrine syringofibroadenoma endocrine mucin producing sweat gland carcinoma extramammary Paget disease hidradenoma hidradenoma papilliferum microcystic adnexal carcinoma papillary eccrine adenoma polymorphous sweat gland carcinoma poroma primary cutaneous mucinous carcinoma sweat gland carcinoma syringocystadenoma papilliferum syringoma
Hair follicles:basaloid follicular hamartoma cutaneous lymphadenoma fibrofolliculoma / trichodiscoma hair follicle nevus pilomatrixoma trichilemmoma trichoepithelioma / trichoblastoma trichofolliculoma tumor of the follicular infundibulum (pending)
Sebaceous glands:sebaceous hyperplasia nevus sebaceus of Jadassohn sebaceoma sebaceous adenoma sebaceous carcinoma
Premalignant / in situ:actinic keratosis bowenoid papulosis condyloma extramammary Paget disease HPV associated SIL HPV independent SIL penile intraepithelial neoplasia squamous cell carcinoma in situ / Bowen disease
Carcinoma (nonadnexal):basal cell carcinoma keratoacanthoma / SCC keratoacanthoma type lymphoepithelioma-like carcinoma mucoepidermoid carcinoma squamous cell carcinoma verrucous carcinoma
Lymphoma and related disorders (see also Lymphoma chapter):cutaneous lymphoid hyperplasia
Primary cutaneous B cell lymphoma (PCBCL):EBV+ mucocutaneous ulcer (pending) intravascular primary cutaneous diffuse large B cell lymphoma, leg type primary cutaneous follicle center lymphoma primary cutaneous marginal zone lymphoma
Cutaneous T cell lymphoma (CTCL):extranodal NK / T cell lymphoma lymphomatoid papulosis mycosis fungoides mycosis fungoides special variants primary cutaneous acral CD8+ primary cutaneous anaplastic large cell lymphoma primary cutaneous CD4+ small / medium primary cutaneous CD8+ aggressive epidermotropic T cell lymphoma primary cutaneous gamma delta primary cutaneous PTCL, NOS (pending) Sézary syndrome subcutaneous panniculitis-like systemic EBV+ of childhood
Leukemic infiltrates of skin and cutaneous mastocytosis:blastic plasmacytoid dendritic cell neoplasm cutaneous mastocytosis leukemia cutis myeloid sarcoma
Histiocytoses:juvenile xanthogranuloma Langerhans cell histiocytosis multicentric reticulohistiocytosis Rosai-Dorfman disease (RDD)
Vascular tumors:angiokeratoma angiosarcoma atypical vascular lesion post radiation benign lymphangioendothelioma / acquired progressive lymphangioma composite hemangioendothelioma cutaneous epithelioid angiomatous nodule epithelioid hemangioendothelioma hemangioendothelioma-kaposiform hemangioendothelioma-retiform intravascular papillary endothelial hyperplasia Kaposi sarcoma lymphangioma / lymphatic malformation papillary intralymphatic angioendothelioma tufted angioma
Hemangioma variants:acquired elastotic hemangioma (pending) angiolymphoid hyperplasia with eosinophilia capillary hemangioma cavernous hemangioma congenital hemangioma (pending) epithelioid angiomatous nodule (pending) glomeruloid hemangioma glomus tumor hobnail hemangioma infantile hemangioma lobular capillary hemangioma microvenular hemangioma myopericytoma / myofibroma spindle cell hemangioma symplastic hemangioma (pending) verrucous hemangioma
Malformations, ectasias and hamartomas of vascular origin:arteriovenous malformation (pending) capillary malformations (pending) diffuse dermal angiomatosis (pending) eccrine angiomatous hamartoma reactive angioendotheliomatosis (pending) telangiectases (pending) venous lake (pending) venous malformations
Neural tumors:epithelial sheath neuroma (pending) granular cell tumor malignant granular cell tumor (pending) Merkel cell carcinoma neurothekeoma palisaded encapsulated neuroma
Cutaneous muscle tumors & hamartomas:alveolar rhabdomyosarcoma angioleiomyoma Becker's nevus embryonal rhabdomyosarcoma leiomyoma leiomyosarcoma pleomorphic rhabdomyosarcoma
Nail tumors:normal nail histology and grossing (pending) onychocytic carcinoma (pending) onychocytic matricoma (pending) onychomatricoma (pending) onychopapilloma (pending) subungual exostosis superficial acral fibromyxoma
Other tumors of skin:benign (mature) cystic teratoma Borst-Jadassohn phenomenon connective tissue nevus endometriosis meningothelial hamartoma of scalp metastatic nevus lipomatosus superficialis supernumerary digit white sponge nevus xanthoma
Topics associated with other chapters: DFSP

Stains-Keratinocytic and adnexal neoplasms: adipophilin (sebaceous neoplasms) (pending) AE1 / AE3 BerEP4 (BCC) CD10 (trichoepithelioma versus BCC) CD34 (trichoepithelioma versus BCC) CEA CK5/6 CK7 CK20 EMA PHLDA1 (trichoepithelioma versus BCC) (pending) p40 p63

Stains-Spindle cell neoplasms: AE1 / AE3 ALK CD10 CD31 CD34 CD99 desmin ERG Factor XIIIa SMA vimentin
Melanocytic markers: HMB45 MelanA / MART1 MITF NGFR / p75 (pending) PRAME S100 SOX10

Stains-Specialized markers: BAP1 BRAF MLH1 MLH3 (pending) MSH2 MSH6 PMS2 p16

Superpages: entire chapterimagesvirtual slides
Index (Alphabetical table of contents)
A-E:acanthoma fissuratum (pending) acquired digital fibrokeratoma acquired elastotic hemangioma (pending) actinic keratosis adenoid cystic carcinoma (primary cutaneous) alveolar rhabdomyosarcoma angiofibroma / fibrous papule angiokeratoma angioleiomyoma angiolymphoid hyperplasia with eosinophilia angiomatoid fibrous histiocytoma angiosarcoma apocrine tubular adenoma arteriovenous malformation (pending) atypical fibroxanthoma atypical vascular lesion post radiation basal cell carcinoma basaloid follicular hamartoma Becker's nevus benign (mature) cystic teratoma benign lymphangioendothelioma / acquired progressive lymphangioma blastic plasmacytoid dendritic cell neoplasm Borst-Jadassohn phenomenon bowenoid papulosis capillary hemangioma capillary malformations (pending) cavernous hemangioma clear cell acanthoma clear cell papulosis collagenous fibroma composite hemangioendothelioma condyloma congenital hemangioma (pending) connective tissue nevus cutaneous epithelioid angiomatous nodule cutaneous fibroepithelial polyps cutaneous lymphadenoma cutaneous lymphoid hyperplasia cutaneous mastocytosis cutaneous mixed tumor / chondroid syringoma cylindroma cystic / cavernous lymphangioma dermatofibroma (cutaneous fibrous histiocytoma) dermatomyofibroma dermatosis papulosa nigra dermoid cyst diffuse dermal angiomatosis (pending) digital myxoid cyst (pending) digital papillary adenocarcinoma dilated pore of Winer (pending) EBV+ mucocutaneous ulcer (pending) eccrine angiomatous hamartoma eccrine spiradenoma eccrine syringofibroadenoma embryonal rhabdomyosarcoma endocrine mucin producing sweat gland carcinoma endometriosis epidermal (epidermoid) type epidermal nevus epidermolytic acanthoma epithelial sheath neuroma (pending) epithelioid angiomatous nodule (pending) epithelioid hemangioendothelioma extramammary Paget disease extranodal NK / T cell lymphoma
F-N:fibrofolliculoma / trichodiscoma glomeruloid hemangioma glomus tumor granular cell tumor hair follicle nevus hemangioendothelioma-kaposiform hemangioendothelioma-retiform hidradenoma hidradenoma papilliferum hidrocystoma hobnail hemangioma HPV associated SIL HPV independent SIL ILVEN (pending) infantile hemangioma intravascular intravascular papillary endothelial hyperplasia inverted follicular keratosis juvenile xanthogranuloma Kaposi sarcoma keloid keratoacanthoma / SCC keratoacanthoma type Langerhans cell histiocytosis large cell acanthoma leiomyoma leiomyosarcoma leukemia cutis lobular capillary hemangioma lymphangioma / lymphatic malformation lymphoepithelioma-like carcinoma lymphomatoid papulosis malignant granular cell tumor (pending) melanoacanthoma meningothelial hamartoma of scalp Merkel cell carcinoma metastatic microcystic adnexal carcinoma microvenular hemangioma mucoepidermoid carcinoma multicentric reticulohistiocytosis multinucleate cell angiohistiocytoma mycosis fungoides mycosis fungoides special variants myeloid sarcoma myoepithelioma myopericytoma / myofibroma neurothekeoma nevus comedonicus (pending) nevus lipomatosus superficialis nevus sebaceus of Jadassohn nevus with “skyline” basal celllayer (PENS) (pending) normal nail histology and grossing (pending)
O-Z:onychocytic carcinoma (pending) onychocytic matricoma (pending) onychomatricoma (pending) onychopapilloma (pending) other cysts palisaded encapsulated neuroma papillary eccrine adenoma papillary intralymphatic angioendothelioma penile intraepithelial neoplasia pilomatrixoma pleomorphic dermal sarcoma pleomorphic fibroma pleomorphic rhabdomyosarcoma polymorphous sweat gland carcinoma porokeratosis poroma primary cutaneous acral CD8+ primary cutaneous anaplastic large cell lymphoma primary cutaneous CD4+ small / medium primary cutaneous CD8+ aggressive epidermotropic T cell lymphoma primary cutaneous diffuse large B cell lymphoma, leg type primary cutaneous follicle center lymphoma primary cutaneous gamma delta primary cutaneous marginal zone lymphoma primary cutaneous mucinous carcinoma primary cutaneous PTCL, NOS (pending) proliferating pilar tumor pseudocarcinomatous hyperplasia (pending) reactive angioendotheliomatosis (pending) Rosai-Dorfman disease (RDD) Sézary syndrome sclerotic fibroma sebaceoma sebaceous adenoma sebaceous carcinoma sebaceous hyperplasia seborrheic keratosis spindle cell hemangioma squamous cell carcinoma squamous cell carcinoma in situ / Bowen disease staging-Merkel cell carcinoma staging-nonmelanocytic carcinoma steatocystoma subcutaneous panniculitis-like subungual exostosis superficial acral fibromyxoma superficial angiomyxoma supernumerary digit sweat gland carcinoma symplastic hemangioma (pending) synovial cysts syringocystadenoma papilliferum syringoma systemic EBV+ of childhood telangiectases (pending) trichilemmal (pilar) type trichilemmoma trichoepithelioma / trichoblastoma trichofolliculoma tufted angioma tumor of the follicular infundibulum (pending) vellus hair cyst venous lake (pending) venous malformations verrucous carcinoma verrucous hemangioma warty dyskeratoma white sponge nevus WHO classification (pending) xanthoma
Skin nonmelanocytic tumor books

Bhawan: 2022

Biswas: 2017

Bolognia: 2017

Brenn: 2017

Brenn: 2021

Busam: 2015

Calonje: 2019

Carter: 2015

Cerroni: 2020

Dadzie: 2016

Elder: 2022

Elder: 2020

Elston: 2018

Gardner: 2019

Gru: 2023

IARC: 2018

Johnston: 2023

Patterson: 2020

Plaza: 2016

Rapini: 2021

Subtil: 2019



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