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Skin nonmelanocytic tumor

Authors: Ossama Abbas, M.D., Maryam Aghighi, M.D., Aadil Ahmed, M.D., Ohoud Aljarbou, M.D., Masoud Asgari, M.D., Phyu Aung, M.D., Ph.D., Laura Battle, M.D., Richard A. Carr, M.B.Ch.B., Sheng Chen, M.D., Ph.D., Jarish Cohen, M.D., Ph.D., Mary Dick, M.D., Andrew L.J. Dunn, M.D., Hillary Rose Elwood, M.D., María-Teresa Fernández-Figueras, Ph.D., Maria C. Ferrufino-Schmidt, M.D., Jerad M. Gardner, M.D., Pavandeep Gill, M.D., Christopher S. Hale, M.D., Lamiaa Hamie, M.D., M.Sc., Mowafak Hamodat, M.B.Ch.B., M.Sc., Christine E. Jabcuga, M.D., Antonina Kalmykova, M.D., Robert E. LeBlanc, M.D., Philip LeBoit, M.D., Bonnie A. Lee, M.D., Thai Yen Ly, M.D., Mario L. Marques-Piubelli, M.D., Anthony Martinez, M.D., Phillip H. McKee, M.D., Jennifer M. McNiff, M.D., Roberto N. Miranda, M.D., Haruto Nishida, M.D., Ph.D., Noelia Pérez Muñoz, M.D., Nat Pernick, M.D., Hong Qu, M.D., Nicole Riddle, M.D., Shira Ronen, M.D., Simon F. Roy, M.D., Eleanor Russell-Goldman, M.D., Ph.D., Jasmine Saleh, M.D., M.P.H., Christian Salib, M.D., Nikhil Sangle, M.D., Omar P. Sangueza, M.D., Sara C. Shalin, M.D., Ph.D., Vijay Shankar, M.D., Poonam Sharma, M.B.B.S., Jodi Speiser, M.D., Aravindhan Sriharan, M.D., Saul Suster, M.D., Julie Teruya-Feldstein, M.D., Joel Tjarks, M.D., Ghassan A. Tranesh, M.D., Nicholas Turnbull, M.B.Ch.B., V. Claire Vaughan, M.D., Noreen M. Walsh, M.D., Joshua Wisell, M.D., Shaofeng Yan, M.D., Ph.D., Sherehan Zada, M.D., Brandon Zelman, D.O.

Minor changes: 3 May 2021

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Related chapters: Skin melanocytic tumor, Skin nontumor, Soft tissue

Editorial Board oversight: Hillary Rose Elwood, M.D. (last reviewed March 2019), Robert E. LeBlanc, M.D. (last reviewed December 2020)
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Table of contents
General:books staging-Merkel cell carcinoma staging-nonadnexal carcinoma
Benign (nonmelanotic) epidermal tumors or tumor-like lesions:Becker's nevus clear cell acanthoma clear cell papulosis epidermal nevus epidermolytic acanthoma (pending) inverted follicular keratosis large cell acanthoma melanoacanthoma porokeratosis seborrheic keratosis warty dyskeratoma
Fibrous, fibrohistiocytic and myofibroblastic neoplasms:acquired digital fibrokeratoma angiofibroma / fibrous papule angiomatoid fibrous histiocytoma atypical fibroxanthoma collagenous fibroma dermatofibroma (cutaneous fibrous histiocytoma) dermatofibroma (cutaneous fibrous histiocytoma)-aneursymal dermatofibroma (cutaneous fibrous histiocytoma)-cellular dermatofibroma (cutaneous fibrous histiocytoma)-epithelioid dermatofibroma (cutaneous fibrous histiocytoma)-hemosiderotic (pending) dermatofibroma (cutaneous fibrous histiocytoma)-lipidized (pending) dermatomyofibroma fibroepithelial polyp keloid multinucleate cell angiohistiocytoma (pending) myoepithelioma pleomorphic dermal sarcoma pleomorphic fibroma sclerotic fibroma superficial angiomyxoma
Cysts:bronchogenic cyst cutaneous ciliated cyst dermoid cyst digital myxoid cyst (pending) dilated pore of Winer (pending) epidermal (epidermoid) type hidrocystoma steatocystoma trichilemmal (pilar) type vellus hair cyst
Adnexal tumors:adnexal tumors-general
Sweat gland derived (apocrine & eccrine glands):adenoid cystic carcinoma (primary cutaneous) apocrine tubular adenoma chondroid syringoma cylindroma digital papillary adenocarcinoma eccrine spiradenoma eccrine syringofibroadenoma endocrine mucin producing sweat gland carcinoma extramammary Paget disease hidradenoma hidradenoma papilliferum microcystic adnexal carcinoma papillary eccrine adenoma poroma primary cutaneous mucinous carcinoma sweat gland carcinoma syringocystadenoma papilliferum syringoma
Hair follicles:basaloid follicular hamartoma cutaneous lymphadenoma fibrofolliculoma / trichodiscoma hair follicle nevus pilomatrixoma proliferating pilar tumor trichilemmoma trichoepithelioma / trichoblastoma trichofolliculoma tumor of the follicular infundibulum (pending)
Sebaceous glands:sebaceous hyperplasia nevus sebaceus of Jadassohn sebaceoma sebaceous adenoma sebaceous carcinoma
Premalignant / in situ:actinic keratosis bowenoid papulosis squamous cell carcinoma in situ / Bowen disease
Carcinoma (nonadnexal):adenosquamous carcinoma basal cell carcinoma keratoacanthoma lymphoepithelioma-like carcinoma mucoepidermoid carcinoma squamous cell carcinoma acantholytic squamous cell carcinoma spindle cell squamous cell carcinoma verrucous carcinoma
Lymphoma and related disorders (see also Lymphoma chapter):lymphoid hyperplasia primary cutaneous lymphoma
B cell neoplasms:cutaneous marginal zone lymphoma / MALT primary cutaneous diffuse large B cell lymphoma, leg type primary cutaneous follicle center lymphoma
T cell / NK cell neoplasms:primary cutaneous anaplastic large cell lymphoma lymphomatoid papulosis mycosis fungoides Pagetoid reticulosis
Other:cutaneous mastocytosis Jessner lymphocytic infiltration of skin leukemia cutis multicentric reticulohistiocytosis
Vascular tumors:acquired tufted angioma angiokeratoma angioleiomyoma angiosarcoma bacillary angiomatosis benign lymphangioendothelioma / acquired progressive lymphangioma capillary / pyogenic granuloma eccrine angiomatous hamartoma hemangioendothelioma-Kaposiform hemangioendothelioma-retiform intravascular papillary endothelial hyperplasia lymphangioma / lymphatic malformation verruga peruana
Hemangioma variants:arteriovenous malformation (pending) capillary hemangioma cavernous hemangioma epithelioid hemangioma / angiolymphoid hyperplasia with eosinophils glomeruloid hemangioma hobnail hemangioma infantile hemangioma microvenular hemangioma spindle cell hemangioma verrucous hemangioma
Neural tumors:granular cell tumor Merkel cell carcinoma neurothekeoma palisaded encapsulated neuroma
Other tumors of skin:benign (mature) cystic teratoma Borst-Jadassohn phenomenon connective tissue nevus endometriosis juvenile xanthogranuloma leiomyoma leiomyosarcoma meningothelial hamartoma of scalp metastatic nevus lipomatosus superficialis supernumerary digit white sponge nevus xanthoma
Topics associated with other chapters: blastic plasmacytic dendritic cell neoplasm (BPDCN) DFSP Langerhans cell histiocytosis

Stains-Keratinocytic and adnexal neoplasms: CEA CK5/6 CK7 EMA p40 p63 pancytokeratin
Stains-Spindle cell neoplasms: CD31 CD34 desmin ERG Factor XIIIa p63 S100
Stains-Specialized markers: BAP1 BRAF MLH1 MSH2 MSH6 PMS2

Superpages: entire chapterimagesvirtual slides
Index (Alphabetical table of contents)
A-E:acantholytic squamous cell carcinoma acquired digital fibrokeratoma acquired tufted angioma actinic keratosis adenoid cystic carcinoma (primary cutaneous) adenosquamous carcinoma adnexal tumors-general angiofibroma / fibrous papule angiokeratoma angioleiomyoma angiomatoid fibrous histiocytoma angiosarcoma apocrine tubular adenoma arteriovenous malformation (pending) atypical fibroxanthoma bacillary angiomatosis basal cell carcinoma basaloid follicular hamartoma Becker's nevus benign (mature) cystic teratoma benign lymphangioendothelioma / acquired progressive lymphangioma Borst-Jadassohn phenomenon bowenoid papulosis bronchogenic cyst capillary / pyogenic granuloma capillary hemangioma cavernous hemangioma chondroid syringoma clear cell acanthoma clear cell papulosis collagenous fibroma connective tissue nevus cutaneous ciliated cyst cutaneous lymphadenoma cutaneous marginal zone lymphoma / MALT cutaneous mastocytosis cylindroma dermatofibroma (cutaneous fibrous histiocytoma) dermatofibroma (cutaneous fibrous histiocytoma)-aneursymal dermatofibroma (cutaneous fibrous histiocytoma)-cellular dermatofibroma (cutaneous fibrous histiocytoma)-epithelioid dermatofibroma (cutaneous fibrous histiocytoma)-hemosiderotic (pending) dermatofibroma (cutaneous fibrous histiocytoma)-lipidized (pending) dermatomyofibroma dermoid cyst digital myxoid cyst (pending) digital papillary adenocarcinoma dilated pore of Winer (pending) eccrine angiomatous hamartoma eccrine spiradenoma eccrine syringofibroadenoma endocrine mucin producing sweat gland carcinoma endometriosis epidermal (epidermoid) type epidermal nevus epidermolytic acanthoma (pending) epithelioid hemangioma / angiolymphoid hyperplasia with eosinophils extramammary Paget disease
F-N:fibroepithelial polyp fibrofolliculoma / trichodiscoma glomeruloid hemangioma granular cell tumor hair follicle nevus hemangioendothelioma-Kaposiform hemangioendothelioma-retiform hidradenoma hidradenoma papilliferum hidrocystoma hobnail hemangioma infantile hemangioma intravascular papillary endothelial hyperplasia inverted follicular keratosis Jessner lymphocytic infiltration of skin juvenile xanthogranuloma keloid keratoacanthoma large cell acanthoma leiomyoma leiomyosarcoma leukemia cutis lymphangioma / lymphatic malformation lymphoepithelioma-like carcinoma lymphoid hyperplasia lymphomatoid papulosis melanoacanthoma meningothelial hamartoma of scalp Merkel cell carcinoma metastatic microcystic adnexal carcinoma microvenular hemangioma mucoepidermoid carcinoma multicentric reticulohistiocytosis multinucleate cell angiohistiocytoma (pending) mycosis fungoides myoepithelioma neurothekeoma nevus lipomatosus superficialis nevus sebaceus of Jadassohn
O-Z:palisaded encapsulated neuroma papillary eccrine adenoma pilomatrixoma pleomorphic dermal sarcoma pleomorphic fibroma porokeratosis poroma primary cutaneous anaplastic large cell lymphoma primary cutaneous diffuse large B cell lymphoma, leg type primary cutaneous follicle center lymphoma primary cutaneous lymphoma primary cutaneous mucinous carcinoma proliferating pilar tumor sclerotic fibroma sebaceoma sebaceous adenoma sebaceous carcinoma sebaceous hyperplasia seborrheic keratosis spindle cell hemangioma spindle cell squamous cell carcinoma squamous cell carcinoma squamous cell carcinoma in situ / Bowen disease staging-Merkel cell carcinoma staging-nonadnexal carcinoma steatocystoma superficial angiomyxoma supernumerary digit sweat gland carcinoma syringocystadenoma papilliferum syringoma trichilemmal (pilar) type trichilemmoma trichoepithelioma / trichoblastoma trichofolliculoma tumor of the follicular infundibulum (pending) vellus hair cyst verrucous carcinoma verrucous hemangioma verruga peruana warty dyskeratoma white sponge nevus xanthoma
Other Topics: Pagetoid reticulosis
Skin nonmelanocytic tumor books

Biswas: 2017

Bolognia: 2017

Brenn: 2017

Busam: 2015

Calonje: 2019

Carter: 2015

Elston: 2018

Gardner: 2019

Gru: 2016

IARC: 2018

Johnston: 2016

Patterson: 2015

Plaza: 2016



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