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Bone marrow neoplastic

Authors: Erika M. Baardsen, D.O., Meenakshi Garg Bansal, M.D., Marie Calaminici, M.D., Ph.D., Jui Choudhuri, M.D., Genevieve M. Crane, M.D., Ph.D., Hans Magne Hamnvåg, M.D., Stanley David Hudnall, M.D., Hatem Kaseb, M.D., Ph.D., M.P.H., Pallavi Khattar, M.D., Joseph Khoury, M.D., Ameet R. Kini, M.D., Ph.D., Huifei Liu, M.D., Ph.D., Sanam Loghavi, M.D. , Rashmi Manur, M.D., M.P.H., Etan Marks, D.O., Daniela Mihova, M.D., Kamran M. Mirza, M.D., Ph.D., Lynh Nguyen, M.D., Oluwatobi "Tobi" Odetola, M.D., Nat Pernick, M.D., Mark Russell, M.D., Valentina Sangiorgio, M.D., Nikhil Sangle, M.D., Yang Shi, M.D., Ph.D., Alexa J. Siddon, M.D., Narittee Sukswai, M.D., Patricia Tsang, M.D., M.B.A., Mariko Yabe, M.D., Ph.D., Sheren Younes, M.D., Syed Zaidi, M.D., Ling Zhang, M.D., Shuchi Zinzuwadia, B.S.

Minor changes: 14 October 2020

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Related chapters: Bone marrow nonneoplastic, Hematology, Lymphoma & related disorders, Lymph nodes and spleen, nonlymphoid

Editorial Board oversight: Genevieve M. Crane, M.D., Ph.D. (last reviewed April 2020)
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Table of contents
Bone marrow - neoplastic myeloid
General:acute leukemia AML general AML classification books transient abnormal myelopoiesis
Recurrent genetic abnormalities:AML with BCR-ABL1 (pending) AML with biallelic mutation of CEBPA (pending) AML with mutated NPM1 (pending) AML with mutated RUNX1 (pending) AML with inv(3)(q21.3;q26.2) or t(3;3)q(21.3;q26.2) (pending) AML with inv(16)(p13.1;q22) or t(16;16)(p13.1;q22) AML (megakaryoblastic) with t(1;22)(p13.3;q13.1) AML with t(6;9)(p23;q34) AML with t(8;21)(q22;q22) AML with t(9;11)(p22;q23) APL with PML-RARA
AML not otherwise specified:AML with minimal differentiation (FAB AML M0) AML without maturation (FAB AML M1) AML with maturation (FAB AML M2) AMML (FAB AML M4) AML M5 M5a M5b AML M6 AMKL M7 acute basophilic leukemia AML with pseudo-Chediak-Higashi anomaly AML hypocellular
Other AML entities defined by the WHO:myeloid leukemia associated with Down syndrome AML therapy related AML with myelodysplasia related changes myeloid sarcoma acute panmyelosis with myelofibrosis
Other AML of clinical relevance:AML with FLT3
Myelodysplastic syndromes (MDS):WHO classification - MDS MDS prognostic scoring MDS in childhood refractory cytopenia of childhood (pending) MDS with single lineage dysplasia MDS with ring sideroblasts MDS with multilineage dysplasia MDS with excess blasts isolated del(5q) MDS unclassifiable
Myeloproliferative neoplasms (MPN):WHO classification - MPN chronic eosinophilic leukemia chronic myeloid leukemia (CML) chronic neutrophilic leukemia essential thrombocythemia polycythemia vera primary myelofibrosis MPN unclassifiable
Mast cell neoplasms: systemic mastocytosis
MDS / MPN: WHO classification - MDS / MPN atypical chronic myeloid leukemia chronic myelomonocytic leukemia juvenile myelomonocytic leukemia MDS / MPN - unclassifiable MDS / MPN with ring sideroblasts and thrombocytosis
Myeloid / lymphoid neoplasms with eosinophilia and gene rearrangement: PDGFRA rearrangement PDGFRB rearrangement FGFR1 rearrangement PCM1-JAK2 (pending)
Myeloid neoplasms with germline predisposition without a pre-existing disorder or organ dysfunction:AML with germline CEBPA mutation (pending) with DDX41 mutation (pending)
Myeloid neoplasms with germline predisposition and pre-existing platelet disorders: with RUNX1 mutation (pending) with ANKRD26 mutation (pending) with ETV6 mutation (pending)
Myeloid neoplasms with germline predisposition and other organ dysfunction: with bone marrow failure (pending) with GATA2 mutation (pending) JMML with NF or Noonan syndrome-like disorders (pending) with telomere biology disorders (pending) with Down syndrome (pending)
Miscellaneous: blastic plasmacytoid dendritic cell neoplasm hypereosinophilic syndrome Down syndrome associated transient abnormal myelopoiesis
Bone marrow - plasma cell and lymphoid neoplasms
Plasma cell neoplasms:plasma cell neoplasms - General MGUS-IgM MGUS-non IgM plasma cell myeloma (multiple myeloma) non secretory myeloma (pending) plasma cell leukemia (pending) plasmacytoma POEMS syndrome (osteosclerotic myeloma) TEMPI syndrome (pending) heavy chain disease
Other:cryoglobulinemia monoclonal immunoglobulin deposition diseases (pending) primary amyloidosis
Precursor lymphoid neoplasms:B cell lymphoblastic lymphoma / leukemia NOS
B lymphoblastic leukemia/lymphoma with recurrent genetic abnormalities:t(1;19)(q23;p13.3) t(5;14)(q31;q32) t(9;22)(q34;q11) t(12;21)(p13;q22) t(v;11q23) BCR-ABL1-like with hyperdiploidy with hypodiploidy with iAMP21 (pending)
NK and T cell precursor lymphoid neoplasms:T lymphoblastic lymphoma / leukemia early T cell precursor lymphoblastic leukemia (pending) NK lymphoblastic leukemia/lymphoma (pending)
Acute leukemia of ambiguous lineage: mixed phenotype ambiguous lineage NOS acute undifferentiated leukemia (pending)
Disorders from other chapters: crystal storing histiocytosis heavy chain deposition disease light chain deposition disease

Bone marrow neoplastic stains: CD3 CD34 CD68 CD117 E-cadherin MPO PAX5 TdT

Superpages: entire chapterimagesvirtual slides
Index (Alphabetical table of contents)
A-E:acute basophilic leukemia acute leukemia acute panmyelosis with myelofibrosis acute undifferentiated leukemia (pending) ambiguous lineage NOS AMKL M7 AML (megakaryoblastic) with t(1;22)(p13.3;q13.1) AML classification AML general AML hypocellular AML M5 AML M6 AML therapy related AML with BCR-ABL1 (pending) AML with biallelic mutation of CEBPA (pending) AML with FLT3 AML with germline CEBPA mutation (pending) AML with inv(16)(p13.1;q22) or t(16;16)(p13.1;q22) AML with inv(3)(q21.3;q26.2) or t(3;3)q(21.3;q26.2) (pending) AML with maturation (FAB AML M2) AML with minimal differentiation (FAB AML M0) AML with mutated NPM1 (pending) AML with mutated RUNX1 (pending) AML with myelodysplasia related changes AML with pseudo-Chediak-Higashi anomaly AML with t(6;9)(p23;q34) AML with t(8;21)(q22;q22) AML with t(9;11)(p22;q23) AML without maturation (FAB AML M1) AMML (FAB AML M4) APL with PML-RARA atypical chronic myeloid leukemia B cell lymphoblastic lymphoma / leukemia NOS BCR-ABL1-like blastic plasmacytoid dendritic cell neoplasm chronic eosinophilic leukemia chronic myeloid leukemia (CML) chronic myelomonocytic leukemia chronic neutrophilic leukemia cryoglobulinemia Down syndrome associated transient abnormal myelopoiesis early T cell precursor lymphoblastic leukemia (pending) essential thrombocythemia
F-N:FGFR1 rearrangement heavy chain disease hypereosinophilic syndrome isolated del(5q) JMML with NF or Noonan syndrome-like disorders (pending) juvenile myelomonocytic leukemia M5a M5b MDS / MPN - unclassifiable MDS / MPN with ring sideroblasts and thrombocytosis MDS in childhood MDS prognostic scoring MDS unclassifiable MDS with excess blasts MDS with multilineage dysplasia MDS with ring sideroblasts MDS with single lineage dysplasia MGUS-IgM MGUS-non IgM mixed phenotype monoclonal immunoglobulin deposition diseases (pending) MPN unclassifiable myeloid leukemia associated with Down syndrome myeloid sarcoma NK lymphoblastic leukemia/lymphoma (pending) non secretory myeloma (pending)
O-Z:PCM1-JAK2 (pending) PDGFRA rearrangement PDGFRB rearrangement plasma cell leukemia (pending) plasma cell myeloma (multiple myeloma) plasma cell neoplasms - General plasmacytoma POEMS syndrome (osteosclerotic myeloma) polycythemia vera primary amyloidosis primary myelofibrosis refractory cytopenia of childhood (pending) systemic mastocytosis T lymphoblastic lymphoma / leukemia t(12;21)(p13;q22) t(1;19)(q23;p13.3) t(5;14)(q31;q32) t(9;22)(q34;q11) t(v;11q23) TEMPI syndrome (pending) transient abnormal myelopoiesis WHO classification - MDS WHO classification - MDS / MPN WHO classification - MPN with ANKRD26 mutation (pending) with DDX41 mutation (pending) with ETV6 mutation (pending) with GATA2 mutation (pending) with RUNX1 mutation (pending) with bone marrow failure (pending) with Down syndrome (pending) with hyperdiploidy with hypodiploidy with iAMP21 (pending) with telomere biology disorders (pending)
Bone marrow neoplastic books

Hsi: 2017

IARC: 2017

Jaffe: 2016

Kantarjian: 2016

Lanzkowsky: 2016

Naeim: 2018



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