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Authors: Engy Abdellatif, M.B.B.Ch., M.D., Ph.D., Elizabeth Abels, M.D., Indu Agarwal, M.D., Jaya Ruth Asirvatham, M.B.B.S., Samuel Bidot, M.D., Luis Blanco, Jr., M.D., Carlos C. Diez Freire, M.D., Jing He, M.D., Shabnam Jaffer, M.D., Julie M. Jorns, M.D., Dia Kamel, M.D., Ph.D., Dina Kandil, M.D., Cansu Karakas, M.D., Belinda Lategan, M.D., Sofia Lérias, M.D., Melinda Lerwill, M.D., Xiaoxian (Bill) Li, M.D., Ph.D., Joshua J.X. Li, M.B.Ch.B., Shahla Masood, M.D., Gustavo Moreno, M.D., Samaneh A. Motanagh, M.D., Kristen E. Muller, D.O., Gahie Nam, M.D., Nat Pernick, M.D., Mirna B. Podoll, M.D., Emily S. Reisenbichler, M.D., Monika Roychowdhury, M.D., Mary Ann Gimenez Sanders, M.D, Ph.D., Ruhani Sardana, M.B.B.S., Kamaljeet Singh, M.D., Sucheta Srivastava, M.D., Eric Statz, M.D., Gary Tozbikian, M.D., Gary M. Tse, M.B.B.S., Paul J. van Diest, M.D., Ph.D., Shoko Vos, M.D., Ph.D., Hind Warzecha, M.D., Debra Zynger, M.D.

Minor changes: 10 July 2020

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Editorial Board oversight: Gary Tozbikian, M.D. (last reviewed September 2019), Debra Zynger, M.D. (last reviewed July 2020)

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Table of contents
General:anatomy axillary lymph nodes biopsy marking devices books core biopsy cytology features to report frozen sections grossing histology pregnancy / lactation sentinel lymph nodes staging WHO classification
Congenital anomalies:amastia / aplasia / hypoplasia / athelia nipple inversion pubertal macromastia supernumerary / accessory tissue
Inflammatory:acute mastitis / abscess amyloid "tumor" chronic inflammation cystic neutrophilic granulomatous mastitis duct ectasia fat necrosis foreign body reaction idiopathic granulomatous mastitis lymphocytic / diabetic mastitis silicone leak / lymphadenopathy SMOLD
Infectious:cysticercosis echinococcal cyst filariasis fungi myiasis sparganosis tuberculosis
Adenosis:adenosis overview adenomyoepithelial apocrine microglandular sclerosing tubular
Other nonneoplastic:apocrine metaplasia collagenous spherulosis columnar cell change / hyperplasia cystic hypersecretory hyperplasia fibroadenomatoid change fibrocystic change fibrosis galactocele gynecomastia juvenile papillomatosis lactating adenoma microcalcifications microcysts mucocele pseudoangiomatous stromal hyperplasia radial scar secretory change subareolar sclerosing duct hyperplasia usual ductal hyperplasia
Fibroepithelial tumors:fibroadenoma phyllodes-general phyllodes-benign phyllodes-borderline phyllodes-malignant
Epithelial-myoepithelial tumors:adenomyoepithelioma myoepithelioma pleomorphic adenoma
Other benign tumors:apocrine adenoma atypical vascular proliferation benign stromal spindle cell tumors cylindroma ductal adenoma eccrine spiradenoma fibromatosis granular cell tumor hamartoma hemangioma inflammatory myofibroblastic tumor intraductal papilloma leiomyoma lipoma lymphangioma myofibroblastoma nipple adenoma syringomatous tumor tubular adenoma
Noninvasive lobular neoplasia:atypical lobular hyperplasia LCIS classic LCIS florid (pending) LCIS pleomorphic
Intraductal atypia:flat epithelial atypia atypical ductal hyperplasia
Ductal carcinoma in situ:DCIS Paget disease
Intraductal papillary carcinoma:encapsulated papillary carcinoma solid papillary carcinoma
Breast cancer:general chemotherapy histologic grading hormonal therapy inflammatory luminal multigene products radiation therapy & cryoprobe risk factors spread and metastases
Invasive breast carcinoma of no special type:ductal NOS choriocarcinomatous glycogen rich lipid rich medullary melanotic oncocytic osteoclastic giant cells pleomorphic sebaceous
Lobular carcinoma:classic pleomorphic
Metaplastic carcinoma:metaplastic fibromatosis-like low grade adenosquamous squamous cell
Neuroendocrine carcinoma:general large cell small cell solid well differentiated
Other carcinoma subtypes, WHO classified:acinic cell adenoid cystic apocrine cribriform invasive micropapillary invasive papillary male invasive microinvasive mucinous mucinous cystadenocarcinoma mucoepidermoid polymorphous secretory tall cell carcinoma with reverse polarity tubular
Other carcinoma subtypes, not WHO classified:basal-like BRCA1 carcinoma BRCA2 carcinoma cystic hypersecretory lymphoepithelioma-like mixed ductal and lobular myoepithelial signet ring cell triple negative (pending) tubulolobular
Sarcoma:general angiosarcoma leiomyosarcoma liposarcoma low grade myofibroblastic sarcoma osteosarcoma rhabdomyosarcoma stromal sarcoma undifferentiated pleomorphic sarcoma
Other malignancies:breast implant associated anaplastic large cell lymphoma lymphoma metastases
Breast stains: androgen receptor calponin CK5 CK7 E-cadherin ER GATA3 GCDFP-15 HER2 breast hormone receptors mammaglobin p40 p63 p120 catenin PDL1 SP142 PR SMMHC / smooth muscle myosin heavy chain

Superpages: entire chapterimagesvirtual slides
Index (Alphabetical table of contents)
A-E:acinic cell acute mastitis / abscess adenoid cystic adenomyoepithelial adenomyoepithelioma adenosis overview amastia / aplasia / hypoplasia / athelia amyloid "tumor" anatomy angiosarcoma apocrine apocrine adenoma apocrine metaplasia atypical ductal hyperplasia atypical lobular hyperplasia atypical vascular proliferation axillary lymph nodes basal-like benign stromal spindle cell tumors biopsy marking devices BRCA1 carcinoma BRCA2 carcinoma breast implant associated anaplastic large cell lymphoma chemotherapy choriocarcinomatous chronic inflammation classic collagenous spherulosis columnar cell change / hyperplasia core biopsy cribriform cylindroma cystic hypersecretory cystic hypersecretory hyperplasia cystic neutrophilic granulomatous mastitis cysticercosis cytology DCIS duct ectasia ductal adenoma ductal NOS eccrine spiradenoma echinococcal cyst encapsulated papillary carcinoma
F-N:fat necrosis features to report fibroadenoma fibroadenomatoid change fibrocystic change fibromatosis fibromatosis-like fibrosis filariasis flat epithelial atypia foreign body reaction frozen sections fungi galactocele general glycogen rich granular cell tumor grossing gynecomastia hamartoma hemangioma histologic grading histology hormonal therapy idiopathic granulomatous mastitis inflammatory inflammatory myofibroblastic tumor intraductal papilloma invasive micropapillary invasive papillary juvenile papillomatosis lactating adenoma large cell LCIS classic LCIS florid (pending) LCIS pleomorphic leiomyoma leiomyosarcoma lipid rich lipoma liposarcoma low grade adenosquamous low grade myofibroblastic sarcoma luminal lymphangioma lymphocytic / diabetic mastitis lymphoepithelioma-like lymphoma male invasive medullary melanotic metaplastic metastases microcalcifications microcysts microglandular microinvasive mixed ductal and lobular mucinous mucinous cystadenocarcinoma mucocele mucoepidermoid multigene products myiasis myoepithelial myoepithelioma myofibroblastoma nipple adenoma nipple inversion
O-Z:oncocytic osteoclastic giant cells osteosarcoma Paget disease phyllodes-benign phyllodes-borderline phyllodes-general phyllodes-malignant pleomorphic pleomorphic adenoma polymorphous pregnancy / lactation pseudoangiomatous stromal hyperplasia pubertal macromastia radial scar radiation therapy & cryoprobe rhabdomyosarcoma risk factors sclerosing sebaceous secretory secretory change sentinel lymph nodes signet ring cell silicone leak / lymphadenopathy small cell SMOLD solid solid papillary carcinoma sparganosis spread and metastases squamous cell staging stromal sarcoma subareolar sclerosing duct hyperplasia supernumerary / accessory tissue syringomatous tumor tall cell carcinoma with reverse polarity triple negative (pending) tuberculosis tubular tubular adenoma tubulolobular undifferentiated pleomorphic sarcoma usual ductal hyperplasia well differentiated WHO classification
Breast books

Bhargava: 2015

Dabbs: 2016

Damjanov: 2017

Hoda: 2017

IARC: 2012

IARC: 2019

Lester: 2016

Schnitt: 2017



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