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Authors: Engy Abdellatif, M.B.B.Ch., M.D., Ph.D., Elizabeth Abels, M.D., Apeksha N. Agarwal, M.B.B.S., M.D., Indu Agarwal, M.D., Areej M. Al Nemer, M.D., Melissa Alexander, M.D., Ph.D., Afaf M. Alsharhan, M.D., Maria A. Arafah, M.D., Jaya Ruth Asirvatham, M.B.B.S., Samuel Bidot, M.D., Luis Blanco, Jr., M.D., Rebecca Czaja, M.P.H., M.D., Carlos C. Diez Freire, M.D., Iskender Sinan Genco, M.D., Paula S. Ginter, M.D., Anthony J. Guidi, M.D., Sabina Hajiyeva, M.D., Jing He, M.D., Shabnam Jaffer, M.D., Zena Jameel, M.D., Julie M. Jorns, M.D., Dia Kamel, M.D., Ph.D., Dina Kandil, M.D., Cansu Karakas, M.D., Melissa Krystel-Whittemore, M.D., Sofia Lérias, M.D., Carissa LaBoy, M.D., Belinda Lategan, M.D., Melinda Lerwill, M.D., Xiaoxian (Bill) Li, M.D., Ph.D., Joshua J.X. Li, M.B.Ch.B., Daniel D. Mais, M.D., Shahla Masood, M.D., Gustavo Moreno, M.D., Samaneh A. Motanagh, M.D., Kristen E. Muller, D.O., Gahie Nam, M.D., Nat Pernick, M.D., Mirna B. Podoll, M.D., Andrii Puzyrenko, M.D., Ph.D., Emily S. Reisenbichler, M.D., Marilin Rosa, M.D., Monika Roychowdhury, M.D., Mary Ann Gimenez Sanders, M.D, Ph.D., Ruhani Sardana, M.B.B.S., Kamaljeet Singh, M.D., Kalliopi P. Siziopikou, M.D., Ph.D., Sucheta Srivastava, M.D., Eric Statz, M.D., Gary Tozbikian, M.D., Gary M. Tse, M.B.B.S., Gulisa Turashvili, M.D., Ph.D. , Paul J. van Diest, M.D., Ph.D., Shoko Vos, M.D., Ph.D., Jessica Wallace, P.A., A.S.C.P., Hind Warzecha, M.D., Hannah Y. Wen, M.D., Ph.D., Jessie M. Wu, M.B.Ch.B., Y. Albert Yeh, M.D., Ph.D., Huina Zhang, M.D., Ph.D., Debra L. Zynger, M.D.

Minor changes: 8 June 2021

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Editorial Board oversight: Julie M. Jorns, M.D. (last reviewed February 2021), Gary Tozbikian, M.D. (last reviewed February 2021), Debra Zynger, M.D. (last reviewed January 2021)

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Table of contents
General:anatomy axillary lymph nodes biopsy marking devices books core biopsy cytology features to report frozen sections frozen section procedure grossing histology pregnancy / lactation sentinel lymph nodes staging WHO classification
Congenital anomalies:amastia / aplasia / hypoplasia / athelia pubertal macromastia supernumerary / accessory tissue
Inflammatory:acute mastitis / abscess amyloid duct ectasia fat necrosis foreign body reaction idiopathic granulomatous mastitis lymphocytic / diabetic mastitis silicone leak / lymphadenopathy SMOLD
Infectious:cystic neutrophilic granulomatous mastitis cysticercosis echinococcal cyst filariasis fungi myiasis sparganosis tuberculosis
Fibrocystic changes:adenomyoepithelial adenosis adenosis apocrine adenosis / atypical apocrine adenosis apocrine metaplasia columnar cell change / hyperplasia fibrocystic changes fibrosis microcysts radial scar / complex sclerosing lesion sclerosing adenosis usual ductal hyperplasia
Other nonneoplastic:collagenous spherulosis cystic hypersecretory hyperplasia galactocele gynecomastia juvenile papillomatosis lactating adenoma microcalcifications mucocele-like lesion pseudoangiomatous stromal hyperplasia secretory change subareolar sclerosing duct hyperplasia transgender breast pathology (pending)
Fibroepithelial tumors:fibroadenoma fibroadenomatoid change hamartoma phyllodes tumor tubular adenoma
Epithelial-myoepithelial tumors:adenomyoepithelioma myoepithelioma pleomorphic adenoma
Other benign tumors:apocrine adenoma atypical vascular proliferation benign stromal spindle cell tumors cylindroma ductal adenoma eccrine spiradenoma fibromatosis granular cell tumor hemangioma inflammatory myofibroblastic tumor intraductal papilloma leiomyoma microglandular adenosis myofibroblastoma nipple adenoma syringomatous tumor
Noninvasive lobular neoplasia:atypical lobular hyperplasia LCIS classic LCIS florid (pending) LCIS pleomorphic
Intraductal atypia:atypical ductal hyperplasia flat epithelial atypia
Ductal carcinoma in situ:DCIS Paget disease
Papillary carcinoma:encapsulated papillary carcinoma solid papillary carcinoma
Breast cancer:atezolizumab chemotherapy histologic grading hormonal therapy inflammatory molecular subtypes multigene products pertuzumab radiation therapy & cryoprobe spread and metastases trastuzumab triple negative breast cancer
Invasive breast carcinoma of no special type and variants:choriocarcinomatous glycogen rich lipid rich medullary NST (ductal) oncocytic osteoclastic giant cells pleomorphic ductal carcinoma sebaceous
Lobular carcinoma:classic pleomorphic lobular carcinoma
Metaplastic carcinoma:fibromatosis-like low grade adenosquamous metaplastic squamous cell
Neuroendocrine carcinoma:large cell neuroendocrine tumor small cell
Other carcinoma subtypes, WHO classified:acinic cell adenoid cystic apocrine cribriform invasive papillary male invasive microinvasive micropapillary mixed NST mucinous mucinous cystadenocarcinoma mucoepidermoid polymorphous secretory carcinoma secretory carcinoma tall cell carcinoma with reverse polarity tubular
Other carcinoma subtypes, not WHO classified:BRCA associated carcinoma cystic hypersecretory lymphoepithelioma-like myoepithelial signet ring cell tubulolobular
Sarcoma:angiosarcoma leiomyosarcoma low grade myofibroblastic sarcoma osteosarcoma rhabdomyosarcoma stromal sarcoma undifferentiated pleomorphic sarcoma
Other malignancies:breast implant associated anaplastic large cell lymphoma lymphoma metastases
Breast stains: androgen receptor calponin CK5 CK7 E-cadherin ER GATA3 GCDFP-15 HER2 breast hormone receptors mammaglobin p40 p63 p120 catenin PDL1 22C3 PDL1 SP142 PR SMMHC / smooth muscle myosin heavy chain

Disorders from other chapters: well differentiated liposarcoma

Superpages: entire chapterimagesvirtual slides
Index (Alphabetical table of contents)
A-E:acinic cell acute mastitis / abscess adenoid cystic adenomyoepithelial adenosis adenomyoepithelioma adenosis amastia / aplasia / hypoplasia / athelia amyloid anatomy angiosarcoma apocrine apocrine adenoma apocrine adenosis / atypical apocrine adenosis apocrine metaplasia atezolizumab atypical ductal hyperplasia atypical lobular hyperplasia atypical vascular proliferation axillary lymph nodes benign stromal spindle cell tumors biopsy marking devices BRCA associated carcinoma breast implant associated anaplastic large cell lymphoma chemotherapy choriocarcinomatous classic collagenous spherulosis columnar cell change / hyperplasia core biopsy cribriform cylindroma cystic hypersecretory cystic hypersecretory hyperplasia cystic neutrophilic granulomatous mastitis cysticercosis cytology DCIS duct ectasia ductal adenoma eccrine spiradenoma echinococcal cyst encapsulated papillary carcinoma
F-N:fat necrosis features to report fibroadenoma fibroadenomatoid change fibrocystic changes fibromatosis fibromatosis-like fibrosis filariasis flat epithelial atypia foreign body reaction frozen section procedure frozen sections fungi galactocele glycogen rich granular cell tumor grossing gynecomastia hamartoma hemangioma histologic grading histology hormonal therapy idiopathic granulomatous mastitis inflammatory inflammatory myofibroblastic tumor intraductal papilloma invasive papillary juvenile papillomatosis lactating adenoma large cell LCIS classic LCIS florid (pending) LCIS pleomorphic leiomyoma leiomyosarcoma lipid rich low grade adenosquamous low grade myofibroblastic sarcoma lymphocytic / diabetic mastitis lymphoepithelioma-like lymphoma male invasive medullary metaplastic metastases microcalcifications microcysts microglandular adenosis microinvasive micropapillary mixed NST molecular subtypes mucinous mucinous cystadenocarcinoma mucocele-like lesion mucoepidermoid multigene products myiasis myoepithelial myoepithelioma myofibroblastoma neuroendocrine tumor nipple adenoma NST (ductal)
O-Z:oncocytic osteoclastic giant cells osteosarcoma Paget disease pertuzumab phyllodes tumor pleomorphic adenoma pleomorphic ductal carcinoma pleomorphic lobular carcinoma polymorphous pregnancy / lactation pseudoangiomatous stromal hyperplasia pubertal macromastia radial scar / complex sclerosing lesion radiation therapy & cryoprobe rhabdomyosarcoma sclerosing adenosis sebaceous secretory carcinoma secretory change sentinel lymph nodes signet ring cell silicone leak / lymphadenopathy small cell SMOLD solid papillary carcinoma sparganosis spread and metastases squamous cell staging stromal sarcoma subareolar sclerosing duct hyperplasia supernumerary / accessory tissue syringomatous tumor tall cell carcinoma with reverse polarity transgender breast pathology (pending) trastuzumab triple negative breast cancer tuberculosis tubular tubular adenoma tubulolobular undifferentiated pleomorphic sarcoma usual ductal hyperplasia WHO classification
Breast books

Bhargava: 2015

Dabbs: 2016

Damjanov: 2017

Field: 2020

Hoda: 2017

IARC: 2019

Jiang: 2021

Lester: 2016

Schnitt: 2017



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