Lymphoma & related disorders

Authors: Fouad Abdelhalim, M.D., Cade Arries, M.D., Jayalakshmi Balakrishna, M.D., Kyle Bradley, M.D., M.S., Sanjay Bridgelall, M.D., Konrad Chan, M.D., Jennifer Chapman, M.D., John Kim Choi, M.D., Ph.D., Elizabeth Courville, M.D., Genevieve M. Crane, M.D., Ph.D., Maria C. Ferrufino-Schmidt, M.D., Emily M. Hartsough, B.S., Stanley David Hudnall, M.D., Meghan Hupp, M.D., Elaine S. Jaffe, M.D., Dragan Jevremovic, M.D., Ph.D., Hatem Kaseb, M.D., Ph.D., M.P.H., Mahsa Khanlari, M.D., Matthew M. Klairmont, M.D., Robert E. LeBlanc, M.D., Dragos C. Luca, M.D., Jaleh Mansouri, M.D., M.P.H., Mario L. Marques-Piubelli, M.D., Roberto N. Miranda, M.D., Pawel Mroz, M.D., Ph.D., Carlos A. Murga-Zamalloa, M.D., Rumina Musani, M.D., Cameron Neely, M.D., Nicholas Nowacki, M.D., Chi Young Ok, M.D., Neval Ozkaya, M.D., Nat Pernick, M.D., Nikhil Sangle, M.D., Min Shi, M.D., Ph.D., Lauren Smith, M.D., Mehrnoosh Tashakori, M.D., Ph.D., Guang "Geoff" Yang, M.D., Ph.D., Sheren Younes, M.D., Ling Zhang, M.D.

Minor changes: 5 July 2020

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Related chapters: Bone marrow nonneoplastic, Bone marrow neoplastic, Hematology, Lymph nodes and spleen, nonlymphoid

Editorial Board oversight: Genevieve M. Crane, M.D., Ph.D. (last reviewed March 2020)

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Table of contents

General:books staging-general staging-pediatric staging-primary cutaneous WHO classification-B cell WHO Classification-PTLD WHO classification-T cell

Non-Hodgkin lymphoma:NHL-general cytogenetics morphologic clues hemophagocytic syndrome composite lymphoma

Mature B cell neoplasms

Small B cell lymphomas with a circulating component:CLL SLL B cell monoclonal lymphocytosis prolymphocytic leukemia hairy cell leukemia hairy cell leukemia variant splenic diffuse red pulp

Small B cell lymphomas with lymphoplasmacytic differentiation / marginal zone lymphomas:lymphoplasmacytic lymphoma marginal zone-general MALT-marginal zone MALT-primary sites marginal zone-nodal splenic marginal zone splenic lymphoma with villous lymphocytes pediatric nodal marginal zone lymphoma (pending)

Follicular lymphomas:follicular-usual follicular neoplasia in situ duodenal type pediatric type testis follicular-unusual variants (pending)

Mantle cell lyphomas:MCL-classic in situ mantle cell neoplasia MCL-leukemic nonnodal MCL-aggressive variants

DLBCL and large B cell lymphomas with high grade features:DLBCL-NOS DLBCL-primary sites Burkitt lymphoma Burkitt-like lymphoma with 11q aberration (pending) With MYC and BCL2 or BCL6 rearrangements High grade B cell lymphoma, NOS (pending) CD5+

Large B cell lymphomas-special subtypes:primary mediastinal With IRF4 rearrangement T cell / histiocyte rich DLBCL-primary testicular (pending) EBV+ EBV+ mucocutaneous ulcer (pending) associated with chronic inflammation (pending) fibrin associated (pending) pyothorax associated lymphomatoid granulomatosis plasmablastic lymphoma of oral mucosa type intravascular ALK+ primary effusion lymphoma

Posttransplant lymphoproliferative disorders (PTLD):posttransplant lymphoproliferative disorders PTLD-nondestructive (pending) PTLD-florid follicular hyperplasia (pending) PTLD-infectious mononucleosis PTLD-polymorphic PTLD-monomorphic PTLD-classic Hodgkin graft versus host disease

Other immunosuppression related:associated with primary immune disorders HIV associated HIV associated-examples other immunodeficiency associated

HHV8 associated lymphoproliferative disorders:

Hodgkin lymphoma:nodular lymphocyte predominant Classic HL nodular sclerosis lymphocyte rich mixed cellularity lymphocyte depleted

Mature T/NK cell disorders:T/NK cell disorders-general

T/NK cell disorders with a leukemic component:T cell prolymphocytic leukemia T cell large granular lymphocytic leukemia Chronic lymphoproliferative disorders of NK cells Aggressive NK cell leukemia ATLL Sezary syndrome

Intestinal:enteropathy associated monomorphic epitheliotropic intestinal (pending) Indolent T lymphoproliferative disease of the GI tract

Aggressive NK/T cell disorders:Extranodal NK / T cell lymphoma, nasal type hepatosplenic Peripheral T cell lymphoma, NOS

Anaplastic large cell lymphoma:Anaplastic large cell lymphoma, ALK positive Anaplastic large cell lymphoma, ALK negative

T follicular helper phenotype:angioimmunoblastic

Cutaneous / soft tissue involvement:subcutaneous panniculitis-like primary cutaneous gamma delta Primary cutaneous CD8+ aggressive epidermotropic cytotoxic Primary cutaneous acral CD8+ Primary cutaneous CD4+ small / medium Primary cutaneous CD30+ lymphomatoid papulosis (lyp)

Pediatric NK/t cell disorders:Systemic EBV+ of childhood hydroa vacciniforme-like lymphoma

Splenic hematogenous neoplasms:Chronic myelogenous leukemia DLBCL-spleen fibroblastic reticulum cell tumor follicular dendritic cell tumor hairy cell leukemia hepatosplenic alpha / beta hepatosplenic gamma / delta histiocytic lymphoma / sarcoma interdigitating dendritic cell sarcoma Langerhans cell histiocytosis splenic marginal zone lymphoma prolymphocytic leukemia SLL / CLL

Disorders from other chapters: primary CNS lymphoma primary cutaneous follicle center lymphoma primary cutaneous DLBCL-leg

NonHodgkin lymphoma & myeloma stains: CD3 CD5 CD10 CD15 CD20 CD23 CD30 BCL6 kappa lambda Ki67

Hodgkin lymphoma stains: CD3 CD15 CD20 CD30 CD45 ALK1 EBER PAX5

Superpages: entire chapter images virtual slides

Index (Alphabetical table of contents)

F-N:fibrin associated (pending) fibroblastic reticulum cell tumor follicular dendritic cell tumor follicular neoplasia in situ follicular-unusual variants (pending) follicular-usual graft versus host disease hairy cell leukemia hairy cell leukemia variant hemophagocytic syndrome hepatosplenic hepatosplenic alpha / beta hepatosplenic gamma / delta High grade B cell lymphoma, NOS (pending) histiocytic lymphoma / sarcoma HIV associated HIV associated-examples hydroa vacciniforme-like lymphoma in situ mantle cell neoplasia Indolent T lymphoproliferative disease of the GI tract interdigitating dendritic cell sarcoma intravascular Langerhans cell histiocytosis lymphocyte depleted lymphocyte rich lymphomatoid granulomatosis lymphomatoid papulosis (lyp) lymphoplasmacytic lymphoma MALT-marginal zone MALT-primary sites marginal zone-general marginal zone-nodal MCL-aggressive variants MCL-classic MCL-leukemic nonnodal mixed cellularity monomorphic epitheliotropic intestinal (pending) morphologic clues NHL-general nodular lymphocyte predominant nodular sclerosis

O-Z:other immunodeficiency associated pediatric nodal marginal zone lymphoma (pending) pediatric type Peripheral T cell lymphoma, NOS plasmablastic lymphoma of oral mucosa type posttransplant lymphoproliferative disorders Primary cutaneous acral CD8+ Primary cutaneous CD30+ Primary cutaneous CD4+ small / medium Primary cutaneous CD8+ aggressive epidermotropic cytotoxic primary cutaneous gamma delta primary effusion lymphoma primary mediastinal prolymphocytic leukemia PTLD-classic Hodgkin PTLD-florid follicular hyperplasia (pending) PTLD-infectious mononucleosis PTLD-monomorphic PTLD-nondestructive (pending) PTLD-polymorphic pyothorax associated Sezary syndrome SLL SLL / CLL splenic diffuse red pulp splenic lymphoma with villous lymphocytes splenic marginal zone splenic marginal zone lymphoma staging-general staging-pediatric staging-primary cutaneous subcutaneous panniculitis-like Systemic EBV+ of childhood T cell / histiocyte rich T cell large granular lymphocytic leukemia T cell prolymphocytic leukemia T/NK cell disorders-general testis WHO classification-B cell WHO Classification-PTLD WHO classification-T cell With IRF4 rearrangement With MYC and BCL2 or BCL6 rearrangements

Other Topics: B cell monoclonal lymphocytosis

Lymphoma & related disorders books

Hsi: 2017

IARC: 2017

Jaffe: 2016

Linden: 2015

Naeim: 2018

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