Lymphoma & related disorders

Authors: Fouad Abdelhalim, M.D., Buthaina Al-Maashari, M.D., Cade Arries, M.D., Sepideh Nikki Asadbeigi, M.D., Jayalakshmi Balakrishna, M.D., Puneet Bedi, M.D., Kyle Bradley, M.D., M.S., Sanjay Bridgelall, M.D., Eugene Carneal, M.D., Konrad Chan, M.D., Jennifer Chapman, M.D., John Kim Choi, M.D., Ph.D., Elizabeth Courville, M.D., Genevieve M. Crane, M.D., Ph.D., Mark G. Evans, M.D., Maria C. Ferrufino-Schmidt, M.D., Raul S. Gonzalez, M.D., Emily M. Hartsough, B.S., Stanley David Hudnall, M.D., Meghan Hupp, M.D., Elaine S. Jaffe, M.D., Dragan Jevremovic, M.D., Ph.D., Hatem Kaseb, M.D., Ph.D., M.P.H., Mahsa Khanlari, M.D., Pallavi Khattar, M.D., Matthew M. Klairmont, M.D., Robert E. LeBlanc, M.D., Dragos C. Luca, M.D., Jaleh Mansouri, M.D., M.P.H., Mario L. Marques-Piubelli, M.D., L. Jeffrey Medeiros, M.D., Roberto N. Miranda, M.D., Pawel Mroz, M.D., Ph.D., Carlos A. Murga-Zamalloa, M.D., Rumina Musani, M.D., Cameron Neely, M.D., Nicholas Nowacki, M.D., Chi Young Ok, M.D., Neval Ozkaya, M.D., Nat Pernick, M.D., Nikhil Sangle, M.D., Min Shi, M.D., Ph.D., Lauren Smith, M.D., Mehrnoosh Tashakori, M.D., Ph.D., Julie Teruya-Feldstein, M.D., Carlos A. Torres-Cabala, M.D., Patricia Tsang, M.D., M.B.A., Dietrich Werner, M.D., Samantha C. Wu, B.A., Guang "Geoff" Yang, M.D., Ph.D., Sheren Younes, M.D., Lena Young, D.O., Ling Zhang, M.D.

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Related chapters: Bone marrow nonneoplastic, Bone marrow neoplastic, Hematology, Lymph nodes and spleen, nonlymphoid

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Table of contents

General:books composite lymphoma cytogenetics NHL-general staging staging-primary cutaneous WHO classification-B cell WHO classification-GI hematolymphoid tumors WHO Classification-PTLD WHO classification-T cell

Mature B cell neoplasms

Small B cell lymphomas with a circulating component:CLL SLL Richter syndrome (pending) B cell monoclonal lymphocytosis prolymphocytic leukemia hairy cell leukemia hairy cell leukemia variant Splenic B cell leukemia / lymphoma, unclassifiable (pending) splenic diffuse red pulp

Small B cell lymphomas with lymphoplasmacytic differentiation / marginal zone lymphomas:lymphoplasmacytic lymphoma marginal zone-general MALT-marginal zone marginal zone-nodal splenic marginal zone splenic lymphoma with villous lymphocytes pediatric nodal marginal zone lymphoma (pending)

Follicular lymphoma:follicular-usual follicular neoplasia in situ pediatric type follicular-unusual variants (pending)

Mantle cell lymphoma:MCL-classic in situ mantle cell neoplasia MCL-leukemic nonnodal MCL-aggressive variants

DLBCL and large B cell lymphomas with high grade features:DLBCL-NOS Burkitt lymphoma Burkitt-like lymphoma with 11q aberration (pending) With MYC and BCL2 or BCL6 rearrangements High grade B cell lymphoma, NOS (pending) CD5+

Large B cell lymphomas-special subtypes:primary mediastinal With IRF4 rearrangement T cell / histiocyte rich DLBCL-primary testicular (pending) EBV+ EBV+ mucocutaneous ulcer (pending) fibrin associated (pending) pyothorax associated lymphomatoid granulomatosis plasmablastic lymphoma of oral mucosa type intravascular ALK+ primary effusion lymphoma

Extranodal organ specific lymphoma:DLBCL-primary sites follicular lymphoma-duodenal type primary follicular lymphoma-testis Primary CNS lymphoma

Posttransplant lymphoproliferative disorders (PTLD):posttransplant lymphoproliferative disorders PTLD-nondestructive (pending) PTLD-florid follicular hyperplasia (pending) PTLD-infectious mononucleosis PTLD-polymorphic PTLD-monomorphic PTLD-classic Hodgkin graft versus host disease

Other immunosuppression related:associated with primary immune disorders HIV associated HIV associated-examples other immunodeficiency associated

HHV8 associated lymphoproliferative disorders:HHV8 related DLBCL (pending) HHV8 related germinotrophic lymphoproliferative disorder (pending)

Hodgkin lymphoma:nodular lymphocyte predominant Classic HL nodular sclerosis lymphocyte rich mixed cellularity lymphocyte depleted

Mature T/NK cell disorders:T/NK cell disorders-general

T/NK cell disorders with a leukemic component:T cell prolymphocytic leukemia T cell large granular lymphocytic leukemia Chronic lymphoproliferative disorders of NK cells Aggressive NK cell leukemia ATLL Sezary syndrome

Intestinal:enteropathy associated intestinal T cell lymphoma, NOS (pending) monomorphic epitheliotropic intestinal (pending) Indolent T lymphoproliferative disease of the GI tract

Aggressive NK/T cell disorders:Extranodal NK / T cell lymphoma, nasal type hepatosplenic Peripheral T cell lymphoma, NOS

Anaplastic large cell lymphoma:anaplastic large cell lymphoma, ALK positive anaplastic large cell lymphoma, ALK negative

T follicular helper phenotype:angioimmunoblastic

Cutaneous / soft tissue involvement:subcutaneous panniculitis-like primary cutaneous gamma delta primary cutaneous CD8+ aggressive epidermotropic T cell lymphoma Primary cutaneous acral CD8+ Primary cutaneous CD4+ small / medium Primary cutaneous CD30+ lymphomatoid papulosis (LyP)

Pediatric NK/T cell disorders:Systemic EBV+ of childhood hydroa vacciniforme-like lymphoma

Splenic hematogenous neoplasms:Chronic myelogenous leukemia DLBCL-spleen fibroblastic reticulum cell tumor follicular dendritic cell tumor hairy cell leukemia hepatosplenic alpha / beta hepatosplenic gamma / delta histiocytic lymphoma / sarcoma interdigitating dendritic cell sarcoma Langerhans cell histiocytosis splenic marginal zone lymphoma prolymphocytic leukemia SLL / CLL

Disorders from other chapters: B cell lymphoblastic lymphoma / leukemia NOS T lymphoblastic lymphoma / leukemia Early T cell precursor lymphoblastic leukemia (pending) NK lymphoblastic leukemia/lymphoma (pending) primary cutaneous follicle center lymphoma primary cutaneous DLBCL-leg

NonHodgkin lymphoma & myeloma stains: CD3 CD5 CD10 CD15 CD20 CD23 CD30 BCL6 kappa lambda Ki67

Hodgkin lymphoma stains: CD3 CD15 CD20 CD30 CD45 ALK1 EBER PAX5

Superpages: entire chapter images virtual slides

Index (Alphabetical table of contents)

F-N:fibrin associated (pending) fibroblastic reticulum cell tumor follicular dendritic cell tumor follicular lymphoma-duodenal type follicular neoplasia in situ follicular-unusual variants (pending) follicular-usual graft versus host disease hairy cell leukemia hairy cell leukemia variant hepatosplenic hepatosplenic alpha / beta hepatosplenic gamma / delta HHV8 related DLBCL (pending) HHV8 related germinotrophic lymphoproliferative disorder (pending) High grade B cell lymphoma, NOS (pending) histiocytic lymphoma / sarcoma HIV associated HIV associated-examples hydroa vacciniforme-like lymphoma in situ mantle cell neoplasia Indolent T lymphoproliferative disease of the GI tract interdigitating dendritic cell sarcoma intestinal T cell lymphoma, NOS (pending) intravascular Langerhans cell histiocytosis lymphocyte depleted lymphocyte rich lymphomatoid granulomatosis lymphomatoid papulosis (LyP) lymphoplasmacytic lymphoma MALT-marginal zone marginal zone-general marginal zone-nodal MCL-aggressive variants MCL-classic MCL-leukemic nonnodal mixed cellularity monomorphic epitheliotropic intestinal (pending) NHL-general nodular lymphocyte predominant nodular sclerosis

O-Z:other immunodeficiency associated pediatric nodal marginal zone lymphoma (pending) pediatric type Peripheral T cell lymphoma, NOS plasmablastic lymphoma of oral mucosa type posttransplant lymphoproliferative disorders Primary CNS lymphoma Primary cutaneous acral CD8+ Primary cutaneous CD30+ Primary cutaneous CD4+ small / medium primary cutaneous CD8+ aggressive epidermotropic T cell lymphoma primary cutaneous gamma delta primary effusion lymphoma primary follicular lymphoma-testis primary mediastinal prolymphocytic leukemia PTLD-classic Hodgkin PTLD-florid follicular hyperplasia (pending) PTLD-infectious mononucleosis PTLD-monomorphic PTLD-nondestructive (pending) PTLD-polymorphic pyothorax associated Richter syndrome (pending) Sezary syndrome SLL SLL / CLL Splenic B cell leukemia / lymphoma, unclassifiable (pending) splenic diffuse red pulp splenic lymphoma with villous lymphocytes splenic marginal zone splenic marginal zone lymphoma staging staging-primary cutaneous subcutaneous panniculitis-like Systemic EBV+ of childhood T cell / histiocyte rich T cell large granular lymphocytic leukemia T cell prolymphocytic leukemia T/NK cell disorders-general WHO classification-B cell WHO classification-GI hematolymphoid tumors WHO Classification-PTLD WHO classification-T cell With IRF4 rearrangement With MYC and BCL2 or BCL6 rearrangements

Lymphoma & related disorders books

Hsi: 2017

IARC: 2017

Jaffe: 2016

Linden: 2015

Naeim: 2018

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