Lymphoma & related disorders

Authors: Fouad Abdelhalim, M.D., Buthaina Al-Maashari, M.D., Cade Arries, M.D., Sepideh Nikki Asadbeigi, M.D., Saja Asakrah, M.D., Jon C. Aster, M.D., Ph.D., Jayalakshmi Balakrishna, M.D., Puneet Bedi, M.D., Samuel Bidot, M.D., Kyle Bradley, M.D., M.S., Sanjay Bridgelall, M.D., Konrad Chan, M.D., Jennifer Chapman, M.D., John Kim Choi, M.D., Ph.D., Elizabeth Courville, M.D., Genevieve M. Crane, M.D., Ph.D., Nicholas Joseph Dcunha, M.B.B.S., M.D., Chelsey D. Deel, M.D., Mark G. Evans, M.D., Maria C. Ferrufino-Schmidt, M.D., Raul S. Gonzalez, M.D., Rouba Hadi, M.D., Jordan M. Hall, M.D., Emily M. Hartsough, B.S., Stanley David Hudnall, M.D., Meghan Hupp, M.D., Elaine S. Jaffe, M.D., Dragan Jevremovic, M.D., Ph.D., Béla Kajtár, M.D., Ph.D., Hatem Kaseb, M.D., Ph.D., M.P.H., Mahsa Khanlari, M.D., Pallavi Khattar, M.D., Matthew M. Klairmont, M.D., Robert E. LeBlanc, M.D., Dragos C. Luca, M.D., Marie Therese Manipadam, M.B.B.S., M.D., Jaleh Mansouri, M.D., M.P.H., Mario L. Marques-Piubelli, M.D., L. Jeffrey Medeiros, M.D., Roberto N. Miranda, M.D., Pawel Mroz, M.D., Ph.D., Carlos A. Murga-Zamalloa, M.D., Rumina Musani, M.D., Cameron Neely, M.D., Nicholas Nowacki, M.D., Chi Young Ok, M.D., Neval Ozkaya, M.D., Sudhir Perincheri, M.B.B.S., Ph.D., Nat Pernick, M.D., Nikhil Sangle, M.D., Min Shi, M.D., Ph.D., Michi Shinohara, M.D., Alexa J. Siddon, M.D., Lauren Smith, M.D., Mehrnoosh Tashakori, M.D., Ph.D., Julie Teruya-Feldstein, M.D., Carlos A. Torres-Cabala, M.D., Patricia Tsang, M.D., M.B.A., Jayalakshmi Venkateswaran, M.D., Dietrich Werner, M.D., Samantha C. Wu, B.A., Guang "Geoff" Yang, M.D., Ph.D., Sheren Younes, M.D., Lena Young, D.O., Ling Zhang, M.D.

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Related chapters: Bone marrow nonneoplastic, Bone marrow neoplastic, Hematology, Lymph nodes and spleen, nonlymphoid

Editorial Board oversight: Genevieve M. Crane, M.D., Ph.D. (last reviewed July 2020)

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Table of contents

General:books composite lymphoma cytogenetics NHL-general staging staging-primary cutaneous WHO classification-B cell WHO classification-GI hematolymphoid tumors WHO classification-PTLD WHO classification-T cell

Mature B cell neoplasms

Small B cell lymphomas with a circulating component:CLL / SLL Richter syndrome (pending) B cell monoclonal lymphocytosis prolymphocytic leukemia hairy cell leukemia hairy cell leukemia variant splenic B cell leukemia / lymphoma, unclassifiable (pending) splenic diffuse red pulp

Small B cell lymphomas with lymphoplasmacytic differentiation / marginal zone lymphomas:lymphoplasmacytic lymphoma marginal zone-general MALT-marginal zone marginal zone-nodal splenic marginal zone splenic lymphoma with villous lymphocytes pediatric nodal marginal zone lymphoma (pending)

Follicular lymphoma:follicular-usual follicular neoplasia in situ pediatric type Follicular-unusual variants (pending)

Mantle cell lymphoma:MCL-classic in situ mantle cell neoplasia MCL-leukemic nonnodal MCL-aggressive variants

DLBCL and large B cell lymphomas with high grade features:DLBCL-NOS Burkitt lymphoma Burkitt-like lymphoma with 11q aberration (pending) HGBL with MYC and BCL2 or BCL6 High grade B cell lymphoma, NOS DLBCL CD5+

Large B cell lymphomas-special subtypes:primary mediastinal LBCL with IRF4 T cell / histiocyte rich DLBCL-primary testicular (pending) EBV+ EBV+ mucocutaneous ulcer (pending) fibrin associated (pending) pyothorax associated lymphomatoid granulomatosis plasmablastic lymphoma of oral mucosa type intravascular ALK+ LBCL primary effusion lymphoma

Extranodal organ specific lymphoma:follicular lymphoma-duodenal type primary follicular lymphoma-testis primary CNS lymphoma

Posttransplant lymphoproliferative disorders (PTLD):posttransplant lymphoproliferative disorders PTLD-nondestructive (pending) PTLD-florid follicular hyperplasia (pending) PTLD-infectious mononucleosis PTLD-polymorphic PTLD-monomorphic PTLD-classic Hodgkin graft versus host disease

Other immunosuppression related:associated with primary immune disorders HIV associated HIV associated-examples other immunodeficiency associated

HHV8 associated lymphoproliferative disorders:HHV8 related DLBCL (pending) HHV8 related germinotrophic lymphoproliferative disorder (pending)

Hodgkin lymphoma:nodular lymphocyte predominant classic HL nodular sclerosis CHL lymphocyte rich mixed cellularity CHL lymphocyte depleted

Mature T/NK cell disorders:T/NK cell disorders-general

T/NK cell disorders with a leukemic component:T cell prolymphocytic leukemia T cell large granular lymphocytic leukemia chronic lymphoproliferative disorders of NK cells aggressive NK cell leukemia ATLL Sezary syndrome

Intestinal:enteropathy associated intestinal T cell lymphoma, NOS (pending) monomorphic epitheliotropic intestinal (pending) Indolent T lymphoproliferative disease of the GI tract

Aggressive NK/T cell disorders:extranodal NK / T cell lymphoma, nasal type hepatosplenic T cell lymphoma peripheral T cell lymphoma, NOS

Anaplastic large cell lymphoma:anaplastic large cell lymphoma, ALK positive anaplastic large cell lymphoma, ALK negative

T follicular helper phenotype:angioimmunoblastic

Cutaneous / soft tissue involvement:subcutaneous panniculitis-like primary cutaneous gamma delta primary cutaneous CD8+ aggressive epidermotropic T cell lymphoma primary cutaneous acral CD8+ primary cutaneous CD4+ small / medium primary cutaneous CD30+ lymphomatoid papulosis (LyP)

Pediatric NK/T cell disorders:systemic EBV+ of childhood hydroa vacciniforme-like lymphoma

Splenic hematogenous neoplasms:DLBCL-spleen splenic marginal zone lymphoma prolymphocytic leukemia

Disorders from other chapters: acute lymphoblastic leukemia / lymphoma early T cell precursor lymphoblastic leukemia (pending) NK lymphoblastic leukemia/lymphoma (pending) primary cutaneous follicle center lymphoma primary cutaneous DLBCL-leg T lymphoblastic lymphoma / leukemia

NonHodgkin lymphoma & myeloma stains: CD3 CD5 CD10 CD15 CD20 CD23 CD30 BCL6 kappa lambda Ki67

Hodgkin lymphoma stains: CD3 CD15 CD20 CD30 CD45 ALK1 EBER PAX5

Superpages: entire chapter images virtual slides

Index (Alphabetical table of contents)

F-N:fibrin associated (pending) follicular lymphoma-duodenal type follicular neoplasia in situ Follicular-unusual variants (pending) follicular-usual graft versus host disease hairy cell leukemia hairy cell leukemia variant hepatosplenic T cell lymphoma HGBL with MYC and BCL2 or BCL6 HHV8 related DLBCL (pending) HHV8 related germinotrophic lymphoproliferative disorder (pending) High grade B cell lymphoma, NOS HIV associated HIV associated-examples hydroa vacciniforme-like lymphoma in situ mantle cell neoplasia Indolent T lymphoproliferative disease of the GI tract intestinal T cell lymphoma, NOS (pending) intravascular LBCL with IRF4 lymphomatoid granulomatosis lymphomatoid papulosis (LyP) lymphoplasmacytic lymphoma MALT-marginal zone marginal zone-general marginal zone-nodal MCL-aggressive variants MCL-classic MCL-leukemic nonnodal mixed cellularity monomorphic epitheliotropic intestinal (pending) NHL-general nodular lymphocyte predominant nodular sclerosis

O-Z:other immunodeficiency associated pediatric nodal marginal zone lymphoma (pending) pediatric type peripheral T cell lymphoma, NOS plasmablastic lymphoma of oral mucosa type posttransplant lymphoproliferative disorders primary CNS lymphoma primary cutaneous acral CD8+ primary cutaneous CD30+ primary cutaneous CD4+ small / medium primary cutaneous CD8+ aggressive epidermotropic T cell lymphoma primary cutaneous gamma delta primary effusion lymphoma primary follicular lymphoma-testis primary mediastinal prolymphocytic leukemia PTLD-classic Hodgkin PTLD-florid follicular hyperplasia (pending) PTLD-infectious mononucleosis PTLD-monomorphic PTLD-nondestructive (pending) PTLD-polymorphic pyothorax associated Richter syndrome (pending) Sezary syndrome splenic B cell leukemia / lymphoma, unclassifiable (pending) splenic diffuse red pulp splenic lymphoma with villous lymphocytes splenic marginal zone splenic marginal zone lymphoma staging staging-primary cutaneous subcutaneous panniculitis-like systemic EBV+ of childhood T cell / histiocyte rich T cell large granular lymphocytic leukemia T cell prolymphocytic leukemia T/NK cell disorders-general WHO classification-B cell WHO classification-GI hematolymphoid tumors WHO classification-PTLD WHO classification-T cell

Lymphoma & related disorders books

Crane: 2021

Hsi: 2017

IARC: 2017

Jaffe: 2016

Linden: 2015

Naeim: 2018

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