Home > Lymph nodes & spleen, nonlymphoma
Lymph nodes & spleen, nonlymphoma

Authors: Ahmed Alrajjal, M.D., Simon A. Backer, M.D., Jayalakshmi Balakrishna, M.D., Amy Beckman, M.D., Ryanne A. Brown, M.D., M.B.A., Laura Brown, M.D., Elizabeth Courville, M.D., William D. DePond, M.D., Julie Feldstein, M.D., Ali Gabali, M.D., Ph.D., Jennifer Gordetsky, M.D., Mina Haghighi Abyaneh, M.D., Rick Kapur, M.D., Ph.D., M.Sc., Sumire Kitahara, M.D., Sajna V.M. Kutty, M.D., David Lynch, M.D., Jaleh Mansouri, M.D., M.P.H., Hina Mohsin, M.D., Robert S. Ohgami, M.D., Ph.D., Zenggang Pan, M.D., Ph.D., Nat Pernick, M.D., Olga Pozdnyakova, M.D., Ph.D., Aishwarya Ravindran, M.B.B.S., Karen L. Rech, M.D., Jack Reid, M.D., Sherif A. Rezk, M.D., Valentina Sangiorgio, M.D., Nikhil Sangle, M.D., Vijay Shankar, M.D., Vignesh Shanmugam, M.D., Abdelsalam Sharabi, M.D., Kunwar Singh, M.D., Ingrid Tam, M.Sc., Emina Emilia Torlakovic, M.D., Ph.D., Patricia Tsang, M.D., M.B.A., Tayler A. van den Akker, M.D., Jayalakshmi Venkateswaran, M.D., Sheren Younes, M.D., Ph.D.

Last staff update: 21 December 2022

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Editorial Board oversight: Patricia Tsang, M.D., M.B.A. (last reviewed October 2022), Elizabeth Courville, M.D. (last reviewed December 2022)
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Table of contents
Lymph nodes-general:anatomy & histology-lymph nodes B & T cells books grossing & features to report-lymph nodes Sydney system (pending)
Ectopic tissue / inclusions:adipose tissue decidual reaction epithelial inclusions mesothelial Müllerian salivary gland smooth muscle other ectopic tissue / inclusions
Pigment / foreign material:anthracosis iron lipofuscin melanosis silicone other pigment / foreign material
Lymph nodes-infectious / parasitic disorders:cat scratch disease Epstein Barr virus HIV mycobacteria-atypical / other than TB or leprosy toxoplasmosis other infections
Lymph nodes-inflammatory / reactive disorders:acute nonspecific lymphadenitis Castleman disease dermatopathic lymphadenitis drug hypersensitivity IgG4 related lymphadenopathy (pending) indolent T lymphoblastic proliferations Kawasaki disease Kikuchi disease Kimura disease progressive transformation of germinal centers rheumatoid arthritis reactive B cell rich lymphoid proliferations that can mimic lymphoma (pending) Rosai-Dorfman disease (RDD) systemic lupus erythematosus
Lymph node-nonspecific findings:adult onset Still disease chronic lymphadenitis erythrophagocytosis follicular hyperplasia granulomatous inflammation inflammatory pseudotumor reactive lymphadenopathy other nonspecific findings
Lymph nodes-vascular lesions:angiolipomatous hamartoma angiomyolipoma angiomyomatous hamartoma hemangioma lymphangioma lymphangiomyomatosis vascular transformation of sinuses
Lymph node & spleen-nonlymphoid neoplasms:amyloid chronic myeloid leukemia, extramedullary Erdheim-Chester disease fibroblastic reticulum cell sarcoma follicular dendritic cell sarcoma (FDCS) histiocytic sarcoma indeterminate cell histiocytosis / indeterminate dendritic cell tumor interdigitating dendritic cell / reticulum cell sarcoma Langerhans cell histiocytosis metastases myofibroblastoma plasmacytoma
Spleen-general:anatomy, histology & grossing-Spleen common nonspecific abnormal features splenectomy, rupture & splenosis
Spleen-congenital anomalies:accessory splenic malformations
Spleen-cysts:epithelial cyst mesothelial cyst
Spleen-infectious / inflammatory disorders:abscess acute splenitis granulomatous inflammation uncommon infections infectious mononucleosis Splendore-Hoeppli phenomenon
Spleen-other nonneoplastic disorders:amyloidosis congestive splenomegaly Gaucher disease hereditary spherocytosis immune thrombocytopenia (ITP)
Spleen-vascular tumors:hamartoma hemangioendothelioma hemangioma hemangiopericytoma littoral cell angioma lymphangioma sclerosing angiomatoid nodular transformation
Spleen-other tumors:metastases
Topics hosted in other chapters: blastic plasmacytoid dendritic cell neoplasm (BPDCN) hairy cell leukemia hairy cell leukemia variant hepatosplenic T cell lymphoma Kaposi sarcoma myeloid sarcoma sarcoidosis Sjogren syndrome splenic marginal zone lymphoma splenic diffuse red pulp small B cell lymphoma

Lymph nodes & spleen, nonlymphoid stains: AFB CD1a CD34 CD45 CMV EBER EMA GMS HHV8 IgG4 kappa & lambda light chains S100 Warthin-Starry

Superpages: entire chapterimagesvirtual slides
Index (Alphabetical table of contents)
A-E:abscess accessory acute nonspecific lymphadenitis acute splenitis adipose tissue adult onset Still disease amyloid amyloidosis anatomy & histology-lymph nodes anatomy, histology & grossing-Spleen angiolipomatous hamartoma angiomyolipoma angiomyomatous hamartoma anthracosis B & T cells Castleman disease cat scratch disease chronic lymphadenitis chronic myeloid leukemia, extramedullary common nonspecific abnormal features congestive splenomegaly decidual reaction dermatopathic lymphadenitis drug hypersensitivity epithelial cyst epithelial inclusions Epstein Barr virus Erdheim-Chester disease erythrophagocytosis
F-N:fibroblastic reticulum cell sarcoma follicular dendritic cell sarcoma (FDCS) follicular hyperplasia Gaucher disease granulomatous inflammation grossing & features to report-lymph nodes hamartoma hemangioendothelioma hemangioma hemangiopericytoma hereditary spherocytosis histiocytic sarcoma HIV IgG4 related lymphadenopathy (pending) immune thrombocytopenia (ITP) indeterminate cell histiocytosis / indeterminate dendritic cell tumor indolent T lymphoblastic proliferations infectious mononucleosis inflammatory pseudotumor interdigitating dendritic cell / reticulum cell sarcoma iron Kawasaki disease Kikuchi disease Kimura disease Langerhans cell histiocytosis lipofuscin littoral cell angioma lymphangioma lymphangiomyomatosis Müllerian melanosis mesothelial mesothelial cyst metastases mycobacteria-atypical / other than TB or leprosy myofibroblastoma
O-Z:other ectopic tissue / inclusions other infections other nonspecific findings other pigment / foreign material plasmacytoma progressive transformation of germinal centers reactive B cell rich lymphoid proliferations that can mimic lymphoma (pending) reactive lymphadenopathy rheumatoid arthritis Rosai-Dorfman disease (RDD) salivary gland sclerosing angiomatoid nodular transformation silicone smooth muscle Splendore-Hoeppli phenomenon splenectomy, rupture & splenosis splenic malformations Sydney system (pending) systemic lupus erythematosus toxoplasmosis uncommon infections vascular transformation of sinuses
Lymph nodes & spleen, nonlymphoma books

Ashton-Key: 2016

Auerbach: 2022

Crane: 2021

Duffield: 2020

Hsi: 2017

Hudnall: 2019

Jaffe: 2016

Jiang: 2021

Medeiros: 2017

Medeiros: 2021

Medeiros: 2023

Naeim: 2018

Wang: 2020



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