Home > Lymph nodes & spleen, nonlymphoma
Lymph nodes & spleen, nonlymphoma

Authors: Ahmed Alrajjal, M.D., Jayalakshmi Balakrishna, M.D., Amy Beckman, M.D., Ryanne A. Brown, M.D., M.B.A., Laura Brown, M.D., Elizabeth Courville, M.D., William D. DePond, M.D., Mark G. Evans, M.D., Julie Feldstein, M.D., Ali Gabali, M.D., Ph.D., Jennifer Gordetsky, M.D., Mina Haghighi Abyaneh, M.D., Jayne Healey, M.D., Rick Kapur, M.D., Ph.D., M.Sc., Sajna V.M. Kutty, M.D., David Lynch M.D., Jaleh Mansouri, M.D., M.P.H., Hina Mohsin, M.D., Robert S. Ohgami, M.D., Ph.D., Zenggang Pan, M.D., Ph.D., Nat Pernick, M.D., Olga Pozdnyakova, M.D., Ph.D., Aishwarya Ravindran, M.B.B.S., Karen L. Rech, M.D., Sherif A. Rezk, M.D., Nikhil Sangle, M.D., Vijay Shankar, M.D., Vignesh Shanmugam, M.D., Abdelsalam Sharabi, M.D., Kunwar Singh, M.D., Patricia Tsang, M.D., M.B.A., Tayler A. van den Akker, M.D., Sheren Younes, M.D.

Minor changes: 23 November 2021

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Related chapters: Bone marrow nonneoplastic, Bone marrow neoplastic, Hematology, Lymphoma & related disorders

Editorial Board oversight: Elizabeth Courville, M.D. (last reviewed November 2021), Patricia Tsang, M.D., M.B.A. (last reviewed November 2020)
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Table of contents
Lymph nodes-general:anatomy & histology-lymph nodes B & T cells books grossing & features to report-lymph nodes Sydney system (pending)
Ectopic tissue / inclusions:adipose tissue decidual reaction epithelial inclusions mesothelial Müllerian salivary gland smooth muscle other ectopic tissue / inclusions
Pigment / foreign material:anthracosis iron lipofuscin melanosis silicone other pigment / foreign material
Lymph nodes-infectious / parasitic disorders:cat scratch disease Epstein Barr virus HIV mycobacteria-atypical / other than TB or leprosy toxoplasmosis other infections
Lymph nodes-inflammatory / reactive disorders:acute nonspecific lymphadenitis allergic granulomatosis Castleman disease dermatopathic lymphadenitis drug hypersensitivity indolent T lymphoblastic proliferations Kawasaki disease Kikuchi disease Kimura disease progressive transformation of germinal centers rheumatoid arthritis Rosai-Dorfman disease (RDD) systemic lupus erythematosus
Lymph node-nonspecific findings:adult onset Still disease angiolymphoid hyperplasia with eosinophilia chronic lymphadenitis erythrophagocytosis follicular hyperplasia granulomatous inflammation hemophagocytic lymphohistiocytosis inflammatory pseudotumor reactive lymphadenopathy other nonspecific findings
Lymph nodes-vascular lesions:angiolipomatous hamartoma angiomyolipoma angiomyomatous hamartoma hemangioma lymphangioma lymphangiomyomatosis vascular transformation of sinuses
Lymph node & spleen-nonlymphoid neoplasms:amyloid chronic myeloid leukemia, extramedullary Erdheim-Chester disease fibroblastic reticulum cell sarcoma follicular dendritic cell sarcoma (FDCS) histiocytic sarcoma indeterminate cell histiocytosis / indeterminate dendritic cell tumor interdigitating dendritic cell / reticulum cell sarcoma Langerhans cell histiocytosis metastases myofibroblastoma plasmacytoma
Spleen-general:anatomy, histology & grossing-Spleen splenectomy, rupture & splenosis
Spleen-congenital anomalies:accessory splenic malformations
Spleen-cysts:epithelial cyst mesothelial cyst
Spleen-infectious / inflammatory disorders:abscess acute splenitis foamy macrophages follicular hyperplasia granulomatous inflammation uncommon infections infectious mononucleosis Splendore-Hoeppli phenomenon
Spleen-other nonneoplastic disorders:amyloidosis congestive splenomegaly Gaucher disease hereditary spherocytosis hypersplenism immune thrombocytopenia (ITP) infarction perisplenitis
Spleen-vascular tumors:hamartoma hemangioendothelioma hemangioma hemangiopericytoma littoral cell angioma lymphangioma sclerosing angiomatoid nodular transformation
Spleen-other tumors:undifferentiated pleomorphic sarcoma metastases
Topics hosted in other chapters: blastic plasmacytoid dendritic cell neoplasm (BPDCN) hairy cell leukemia hairy cell leukemia variant hepatosplenic T cell lymphoma Kaposi sarcoma myeloid sarcoma sarcoidosis Sjogren syndrome splenic marginal zone lymphoma splenic diffuse red pulp small B cell lymphoma

Lymph nodes & spleen, nonlymphoid stains: CD1a CD34 CD45 EMA EBER HHV8 S100 AFB GMS

Superpages: entire chapterimagesvirtual slides
Index (Alphabetical table of contents)
A-E:abscess accessory acute nonspecific lymphadenitis acute splenitis adipose tissue adult onset Still disease allergic granulomatosis amyloid amyloidosis anatomy & histology-lymph nodes anatomy, histology & grossing-Spleen angiolipomatous hamartoma angiolymphoid hyperplasia with eosinophilia angiomyolipoma angiomyomatous hamartoma anthracosis B & T cells Castleman disease cat scratch disease chronic lymphadenitis chronic myeloid leukemia, extramedullary congestive splenomegaly decidual reaction dermatopathic lymphadenitis drug hypersensitivity epithelial cyst epithelial inclusions Epstein Barr virus Erdheim-Chester disease erythrophagocytosis
F-N:fibroblastic reticulum cell sarcoma foamy macrophages follicular dendritic cell sarcoma (FDCS) follicular hyperplasia Gaucher disease granulomatous inflammation grossing & features to report-lymph nodes hamartoma hemangioendothelioma hemangioma hemangiopericytoma hemophagocytic lymphohistiocytosis hereditary spherocytosis histiocytic sarcoma HIV hypersplenism immune thrombocytopenia (ITP) indeterminate cell histiocytosis / indeterminate dendritic cell tumor indolent T lymphoblastic proliferations infarction infectious mononucleosis inflammatory pseudotumor interdigitating dendritic cell / reticulum cell sarcoma iron Kawasaki disease Kikuchi disease Kimura disease Langerhans cell histiocytosis lipofuscin littoral cell angioma lymphangioma lymphangiomyomatosis Müllerian melanosis mesothelial mesothelial cyst metastases mycobacteria-atypical / other than TB or leprosy myofibroblastoma
O-Z:other ectopic tissue / inclusions other infections other nonspecific findings other pigment / foreign material perisplenitis plasmacytoma progressive transformation of germinal centers reactive lymphadenopathy rheumatoid arthritis Rosai-Dorfman disease (RDD) salivary gland sclerosing angiomatoid nodular transformation silicone smooth muscle Splendore-Hoeppli phenomenon splenectomy, rupture & splenosis splenic malformations Sydney system (pending) systemic lupus erythematosus toxoplasmosis uncommon infections undifferentiated pleomorphic sarcoma vascular transformation of sinuses
Lymph nodes & spleen, nonlymphoma books

Ashton-Key: 2016

Crane: 2021

Duffield: 2020

Hsi: 2017

Jaffe: 2016

Jiang: 2021

Medeiros: 2017

Medeiros: 2017

Naeim: 2018

O'Malley: 2009

Parker: 2017



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