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Liver & intrahepatic bile ducts

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Table of contents
General:anatomy & histology ascites biopsy books cirrhosis diagnostic patterns-differential diagnosis donor liver frozen section evaluation forms of hepatic injury grossing, frozen section & features to report hepatic failure staging-cholangiocarcinoma staging-hepatocellular carcinoma WHO classification WHO reporting system for liver cytopathology (pending)
Developmental anomalies / cysts:Alagille syndrome benign recurrent intrahepatic cholestasis Caroli disease choledochal cyst congenital hepatic fibrosis extrahepatic biliary atresia foregut cyst intrahepatic biliary atresia Navajo hepatopathy polycystic liver disease progressive familial intrahepatic cholestasis Reye syndrome simple biliary cyst Von Meyenburg complex
Metabolic diseases:alpha-1 antitrypsin deficiency cystic fibrosis erythropoietic protoporphyria Gaucher disease glycogen storage diseases hemochromatosis lysosomal acid lipase deficiency Niemann-Pick disease primary hyperoxaluria Wilson disease
Acute and chronic hepatitis:hepatitis (acute and chronic)-general acute hepatitis-general chronic hepatitis chronic hepatitis-grading / staging
Drug / toxin induced hepatitis:drug / toxin induced hepatitis (DILI)-general drug / toxin induced hepatitis-acetaminophen amiodarone checkpoint inhibitor associated hepatitis methotrexate
Noninfectious hepatitis:alcohol associated liver disease autoimmune hepatitis glycogenic hepatopathy granulomatous hepatitis neonatal hepatitis metabolic dysfunction associated steatotic liver disease (MASLD) / Metabolic dysfunction associated steatohepatitis (MASH)
Viral hepatitis:adenovirus hepatitis chronic viral hepatitis COVID-19 cytomegalovirus hepatitis Epstein-Barr virus hepatitis hepatitis A virus (HAV) hepatitis B virus (HBV) hepatitis C virus (HCV) herpes simplex virus hepatitis
Infectious nonviral:echinococcal cyst Entamoeba histolytica abscess fasciola hepatica other flukes (Clonorchis / Opisthorchis) (pending) pyogenic abscess Q fever schistosomiasis
Biliary tract disease:cholestasis ascending cholangitis autoimmune cholangitis cholangitis lenta / sepsis ductular reaction large duct obstruction primary biliary cholangitis primary sclerosing cholangitis recurrent pyogenic cholangitis secondary biliary cirrhosis
Vascular disorders:vascular disorders-general arterial disorders Budd-Chiari syndrome hereditary hemorrhagic telangiectasia peliosis hepatis portal hypertension portal vein obstruction portosinusoidal vascular disease sinusoidal obstruction syndrome / venoocclusive disease (SOS / VOD)
Systemic conditions:cardiac (congestive) hepatopathy and Fontan associated liver disease pregnancy malnutrition (total parenteral nutrition)
Liver transplantation
Early onset graft injury:liver transplantation overview acute antibody mediated rejection including hyperacute rejection acute T cell mediated rejection transplantation - surgical / vascular complications
Late onset graft injury:chronic antibody mediated rejection chronic rejection late T cell mediated (cellular) rejection recurrent disease
Benign / nonneoplastic:angiomyolipoma bile duct adenoma biliary adenofibroma extramedullary hematopoiesis focal fatty change focal nodular hyperplasia hemangioma hepatic infantile hemangioma hepatocellular adenoma intraductal papillary neoplasm of the bile ducts large regenerative nodule macroregenerative nodule mesenchymal hamartoma nodular regenerative hyperplasia reactive lymphoid hyperplasia / pseudolymphoma segmental atrophy
Hepatocellular dysplasia:high grade dysplastic nodule liver cell dysplasia low grade dysplastic nodule
Hepatocellular carcinoma:hepatocellular carcinoma overview BAP1 mutant HCC (pending) HCC - cytology HCC - clear cell variant HCC - fibrolamellar variant HCC - lymphocyte rich HCC - macrotrabecular massive HCC - sarcomatoid variant HCC - scirrhous type HCC - steatohepatitic HCC - undifferentiated variant
Biliary dysplasia:biliary intraepithelial neoplasia (BILIN) (pending) intraductal papillary mucinous neoplasm (IPMN) of bile ducts (pending) intraductal oncocytic neoplasm (IOPN) of bile ducts (pending) mucinous cystic neoplasm
Cholangiocarcinoma:combined hepatocellular carcinoma-cholangiocarcinoma ICC solid, tubulocystic variant (NIPBL::NACC1 fusion related) (pending) intrahepatic cholangiocarcinoma (small and large duct types)
Other malignancies:angiosarcoma calcifying nested stromal epithelial tumor epithelioid hemangioendothelioma hepatic small vessel neoplasm hepatoblastoma metastases neuroendocrine carcinoma undifferentiated embryonal sarcoma well differentiated neuroendocrine tumor
Liver stains:   AFP albumin ISH (pending) arginase1 beta catenin C4d (pending) CMV C reactive protein (pending) glutamine synthetase (pending) glypican 3 HepPar1 HSP70 (pending) iron PAS reticulin serum amyloid A / SAA trichrome

Superpages: entire chapterimagesvirtual slides
Index (Alphabetical table of contents)
A-E:acute antibody mediated rejection including hyperacute rejection acute hepatitis-general acute T cell mediated rejection adenovirus hepatitis Alagille syndrome alcohol associated liver disease alpha-1 antitrypsin deficiency amiodarone anatomy & histology angiomyolipoma angiosarcoma arterial disorders ascending cholangitis ascites autoimmune cholangitis autoimmune hepatitis BAP1 mutant HCC (pending) benign recurrent intrahepatic cholestasis bile duct adenoma biliary adenofibroma biliary intraepithelial neoplasia (BILIN) (pending) biopsy Budd-Chiari syndrome calcifying nested stromal epithelial tumor cardiac (congestive) hepatopathy and Fontan associated liver disease Caroli disease checkpoint inhibitor associated hepatitis cholangitis lenta / sepsis choledochal cyst cholestasis chronic antibody mediated rejection chronic hepatitis chronic hepatitis-grading / staging chronic rejection chronic viral hepatitis cirrhosis combined hepatocellular carcinoma-cholangiocarcinoma congenital hepatic fibrosis COVID-19 cystic fibrosis cytomegalovirus hepatitis diagnostic patterns-differential diagnosis donor liver frozen section evaluation drug / toxin induced hepatitis (DILI)-general drug / toxin induced hepatitis-acetaminophen ductular reaction echinococcal cyst Entamoeba histolytica abscess epithelioid hemangioendothelioma Epstein-Barr virus hepatitis erythropoietic protoporphyria extrahepatic biliary atresia extramedullary hematopoiesis
F-N:fasciola hepatica focal fatty change focal nodular hyperplasia foregut cyst forms of hepatic injury Gaucher disease glycogen storage diseases glycogenic hepatopathy granulomatous hepatitis grossing, frozen section & features to report HCC - clear cell variant HCC - cytology HCC - fibrolamellar variant HCC - lymphocyte rich HCC - macrotrabecular massive HCC - sarcomatoid variant HCC - scirrhous type HCC - steatohepatitic HCC - undifferentiated variant hemangioma hemochromatosis hepatic failure hepatic infantile hemangioma hepatic small vessel neoplasm hepatitis (acute and chronic)-general hepatitis A virus (HAV) hepatitis B virus (HBV) hepatitis C virus (HCV) hepatoblastoma hepatocellular adenoma hepatocellular carcinoma overview hereditary hemorrhagic telangiectasia herpes simplex virus hepatitis high grade dysplastic nodule ICC solid, tubulocystic variant (NIPBL::NACC1 fusion related) (pending) intraductal oncocytic neoplasm (IOPN) of bile ducts (pending) intraductal papillary mucinous neoplasm (IPMN) of bile ducts (pending) intraductal papillary neoplasm of the bile ducts intrahepatic biliary atresia intrahepatic cholangiocarcinoma (small and large duct types) large duct obstruction large regenerative nodule late T cell mediated (cellular) rejection liver cell dysplasia liver transplantation overview low grade dysplastic nodule lysosomal acid lipase deficiency macroregenerative nodule malnutrition (total parenteral nutrition) mesenchymal hamartoma metabolic dysfunction associated steatotic liver disease (MASLD) / Metabolic dysfunction associated steatohepatitis (MASH) metastases methotrexate mucinous cystic neoplasm Navajo hepatopathy neonatal hepatitis neuroendocrine carcinoma Niemann-Pick disease nodular regenerative hyperplasia
O-Z:other flukes (Clonorchis / Opisthorchis) (pending) peliosis hepatis polycystic liver disease portal hypertension portal vein obstruction portosinusoidal vascular disease pregnancy primary biliary cholangitis primary hyperoxaluria primary sclerosing cholangitis progressive familial intrahepatic cholestasis pyogenic abscess Q fever reactive lymphoid hyperplasia / pseudolymphoma recurrent disease recurrent pyogenic cholangitis Reye syndrome schistosomiasis secondary biliary cirrhosis segmental atrophy simple biliary cyst sinusoidal obstruction syndrome / venoocclusive disease (SOS / VOD) staging-cholangiocarcinoma staging-hepatocellular carcinoma transplantation - surgical / vascular complications undifferentiated embryonal sarcoma vascular disorders-general Von Meyenburg complex well differentiated neuroendocrine tumor WHO classification WHO reporting system for liver cytopathology (pending) Wilson disease
Liver & intrahepatic bile ducts books

Burt: 2023

Husain: 2021

IARC: 2019

Jiang: 2023

Lamps: 2021

Lefkowitch: 2020

NIH: 2022

Odze: 2022

Oshima: 2021

Radu-Ionita: 2020

Srivastava: 2023

Thompson: 2021

Torbenson: 2019

Torbenson: 2021

Torbenson: 2022



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