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Transfusion medicine

Authors: Brian D. Adkins, M.D., Yamac Akgun, M.D., Abdulaziz Al Mana, M.D., M.Sc., Kyle Annen, D.O., Brian D. Arbogast, M.D., Deyze Badarane, M.D., M.P.H., C.P.H., Maha Badawi, M.B.B.S., Sara Bakhtary, M.D., Raisa Balbuena-Merle, M.D., M.H.S., Yigit Baykara, M.D., Garrett S. Booth, M.D., M.S., Jose A. Cancelas, M.D., Ph.D., Timothy Carll, M.D., Tiffany Chambers, M.D., Sanket Choksi, M.D., Kathleen (Cathy) Conry-Cantilena, M.D., Laura Cooling, M.D., Jessica Corean, M.D., Philip Crispin, M.B.B.S., Adenike Eketunde, M.D., M.P.H., Nagla El Zinad, M.B.Ch.B., Murad Elsadawi, M.D., Deanna C. Fang, M.D., Robert Frick, M.D., Melissa R. George, D.O., Thomas J. Gniadek, M.D., Ph.D., Elizabeth A. Godbey, M.D., Aditi Goel, M.D., Richa Gupta, M.D., Hope Hastings, M.D., Louise Helander, M.B.B.S., Isabella M. Holmes, D.O., Bryon P. Jackson, M.D., Rachel Jug, M.B.B.Ch., B.A.O., Matthew S. Karafin, M.D., Sarah Kesterson, M.D., Patricia Kopko, M.D., Devon D. Mahoney, M.D., Gisela Marrero-Rivera, M.D., Ryan A. Metcalf, M.D., Faisal Mukhtar, M.D., Martin S. Ongkeko, M.D., Chinelo P. Onyenekwu, M.D., Katerina Pavenski, M.D., J. Peter R. Pelletier, M.D., Nat Pernick, M.D., Huy P. Pham, M.D., M.P.H., Samantha Phou, M.D., Evelyn M. Potochny, D.O., Jansen N. Seheult, M.B.B.Ch., B.A.O., M.Sc., M.S., M.D., Adeyemi Sofoluwe, M.D., Erica Swenson, D.O., Yvette C. Tanhehco, Ph.D., M.D., M.S., Mamie Thant, M.D., M.S., Reggie Thomasson, M.S., M.D., Mrigender Singh Virk, M.D., Kamille A. West, M.D., Geoffrey Wool, M.D., Ph.D., YanYun Wu, M.D. Ph.D., Crystal Yan, M.D., M.B.A., Furkan Yigitbilek, M.D., Muharrem Yunce, M.D.

Last staff update: 15 July 2025

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Related chapters: Coagulation

Editorial Board oversight: Mrigender Singh Virk, M.D. (last reviewed January 2025)
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Table of contents
General:books
Red blood cell antigens:ABO / H system Duffy system Ii system Kell system Kidd system Lewis system MNS system P1PK GLOB system Rh system
Blood bank testing:ABO discrepancies adsorption studies antibody identification & panel interpretation automation cold autoantibody testing (pending) Coombs test / DAT DAT negative autoimmune hemolytic anemia enzyme treatment (pending) neutralization and lectins (pending) pretransfusion testing red blood cell genotyping warm autoantibody testing
Blood donation:blood donor testing donor collection donor eligibility donor reactions
Transfusion reactions & complications:acute hemolytic transfusion reaction (AHTR) allergic / anaphylactic delayed hemolytic and delayed serologic reactions febrile nonhemolytic fetal / neonatal alloimmune thrombocytopenia hemolytic disease of the fetus and newborn hypotension iron overload platelet refractoriness post-transfusion purpura red blood cell alloimmunization transfusion associated circulatory overload transfusion associated graft versus host disease transfusion related acute lung injury transfusion related immunomodulation (TRIM)
Transfusion transmitted disease:bacteria parasites variant Creutzfeldt-Jakob viruses Zika virus
Transfusion therapy
Blood product manipulation:irradiation pathogen inactivation washing & volume reduction
Other therapy:blood alternatives cold stored platelets cryoprecipitate use granulocyte use massive transfusion plasma use platelet use red blood cell use sickle cell disease whole blood therapy
Immunotherapy:CAR T cell therapy cellular therapy reactions COVID-19 convalescent plasma monoclonal antibody therapy Rh immune globulin
Therapeutic apheresis:ASFA guidelines overview LDL apheresis leukocytapheresis photopheresis plateletpheresis red blood cell exchange therapeutic plasma exchange (TPE)
Stem cell transplant:ABO incompatible HSCT stem cell collection
Quality and compliance:biological product deviation equity (pending) ethics FACT compliance hemovigilance lookbacks patient blood management shelf lives of products tissue banking
Superpages: entire chapterimagesvirtual slides
Index (Alphabetical table of contents)
A-E:ABO / H system ABO discrepancies ABO incompatible HSCT acute hemolytic transfusion reaction (AHTR) adsorption studies allergic / anaphylactic antibody identification & panel interpretation ASFA guidelines overview automation bacteria biological product deviation blood alternatives blood donor testing CAR T cell therapy cellular therapy reactions cold autoantibody testing (pending) cold stored platelets Coombs test / DAT COVID-19 convalescent plasma cryoprecipitate use DAT negative autoimmune hemolytic anemia delayed hemolytic and delayed serologic reactions donor collection donor eligibility donor reactions Duffy system enzyme treatment (pending) equity (pending) ethics
F-N:FACT compliance febrile nonhemolytic fetal / neonatal alloimmune thrombocytopenia granulocyte use hemolytic disease of the fetus and newborn hemovigilance hypotension Ii system iron overload irradiation Kell system Kidd system LDL apheresis leukocytapheresis Lewis system lookbacks massive transfusion MNS system monoclonal antibody therapy neutralization and lectins (pending)
O-Z:P1PK GLOB system parasites pathogen inactivation patient blood management photopheresis plasma use platelet refractoriness platelet use plateletpheresis post-transfusion purpura pretransfusion testing red blood cell alloimmunization red blood cell exchange red blood cell genotyping red blood cell use Rh immune globulin Rh system shelf lives of products sickle cell disease stem cell collection therapeutic plasma exchange (TPE) tissue banking transfusion associated circulatory overload transfusion associated graft versus host disease transfusion related acute lung injury transfusion related immunomodulation (TRIM) variant Creutzfeldt-Jakob viruses warm autoantibody testing washing & volume reduction whole blood therapy Zika virus
Transfusion medicine books

AABB: 2021

AABB: 2021

Cohn: 2023

Cushing: 2020

Dunbar: 2020

Friedman: 2023

Harmening: 2018

Howard: 2016

Hughes: 2018

Katz Karp: 2020

Key: 2017

Kreuter: 2017

McCullough: 2016

McPherson: 2021

Quillen: 2016

Reid: 2012

Shaz: 2018

Simon: 2022

Talebi: 2016

Vassallo: 2021

Volod: 2023



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