Home   Chapter Home   Jobs   Conferences   Fellowships   Books




Clinical chemistry 

Adrenal Gland

Saline suppression test


Author: Renu Virk, M.D. (see Authors page)

Revised: 22 September 2012, last major update - February 2010

Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.




● To confirm the diagnosis of primary aldosteronism (J Clin Endocrinol Metab 2006;91:2618)

● Other tests recommended for screening or confirmation are captopril suppression test and fludrocortisone suppression (Horm Metab Res 2010 Jan 29 [Epub ahead of print])




● Infuse 2L of 0.9% saline over 4 hours ("saline infusion test") OR give oral NaCl tablets 10-12 gm daily for 3 days ("oral sodium loading test")

Blood levels: plasma aldosterone greater than 5 ng/dl (140 pmol/L) confirms the diagnosis of primary hyperaldosteronism

Urine levels: collect 24 hour urine for aldosterone, creatinine (to assess the adequacy of urine collection), and sodium (to ensure adequate intake) on the last day of sodium chloride administration; aldosterone levels > 10 μg/24 hours (28 nmol/24 hours) confirms the diagnosis


Clinical features


● More difficult to perform than captopril suppression test, with comparable accuracy in patients with high sodium intake (Hypertension 2007;50:424)


End of Clinical chemistry > Adrenal Gland > Saline Suppression Test



This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must also be interpreted in the context of a patient's clinical data using reasonable medical judgment.  This website should not be used as a substitute for the advice of a licensed physician.


All information on this website is protected by copyright of PathologyOutlines.com, Inc.  Information from third parties may also be protected by copyright.  Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).