Chemistry
Adrenal related
Saline suppression test



Topic Completed: 1 February 2010

Revised: 31 December 2018, last major update February 2010

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: Saline suppression [title]
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Cite this page: Virk R. Saline suppression test. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/adrenalsalinesuppression.html. Accessed April 18th, 2019.
Definition / general
Indication:

Methodology:
  • Infuse 2L of 0.9% saline over 4 hours ("saline infusion test") OR give oral NaCl tablets 10 - 12 gm daily for 3 days ("oral sodium loading test")
  • Blood levels: plasma aldosterone greater than 5 ng/dl (140 pmol/L) confirms the diagnosis of primary hyperaldosteronism
  • Urine levels: collect 24 hour urine for aldosterone, creatinine (to assess the adequacy of urine collection), and sodium (to ensure adequate intake) on the last day of sodium chloride administration
    • Aldosterone levels > 10 μg/24 hours (28 nmol/24 hours) confirms the diagnosis
Clinical features
  • More difficult to perform than captopril suppression test, with comparable accuracy in patients with high sodium intake (Hypertension 2007;50:424)
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