Bladder
Cytology
Cytology - normal findings

Author: Rugvedita Parakh, M.D. (see Authors page)

Revised: 21 June 2016, last major update December 2014

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Bladder [title] normal cytology
Cite this page: Cytology - normal findings. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/bladdercytologynormal.html. Accessed December 4th, 2016.
Cytology Description
Voided urine
  • Paucicellular
  • Urothelial cells, squamous cells, inflammatory cells and possibly red blood cells
  • The umbrella cells have one nucleus, abundant delicate cytoplasm, low N/C ratio, smooth nuclear contours with fine chromatin pattern and a small chromocenter
  • The basal and intermediate layers are smaller and have a columnar or cuboidal appearance; the nuclei are round with smooth nuclear contours with a fine chromatin pattern
  • Nucleoli are either absent or single and minute
  • Reactive conditions (e.g. urolithiasis, post instrumentation) demonstrate clusters of basal and intermediate urothelial cells


Instrumentation related urine
  • More cellular
  • Presence of clusters of urothelial cells forming cell balls and pseudopapillary clusters
  • The urothelial cells have a low N/C ratio, round nuclei, fine chromatin pattern and smooth nuclear contours
  • Instrumentation effect: crowded cluster formations, hyperchromasia and distinct nucleoli; may lead to a false positive diagnosis


Ileal conduit urine
  • Cellular
  • Many degenerated single cells (oval with pyknotic nuclei) and few glandular cells (vacuolated cytoplasm, hyperchromatic nuclei but preserved N/C ratio of normal cells)
  • Dirty background
  • Non-specific eosinophilic cytoplasmic inclusions
  • A potential pitfall due to hyperchromasia
Cytology Images

Images hosted on Pathout server:
Missing Image

Urine cytology