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Bladder
Cystitis
Hemorrhagic cystitis
Author: Nat Pernick, M.D. (see Authors page)
Revised: 21 December 2009, UPDATE IN PROGRESS
Copyright: (c) 2002-2009, PathologyOutlines.com, Inc.
Definition
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● Clinical syndrome of gross hematuria, often with irritative bladder symptoms
Terminology
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Epidemiology
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Sites
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Etiology
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● Due to cyclophosphamide, methotrexate, radiation therapy (eMedicine); also adenovirus, herpes simplex virus, CMV
● Post allogeneic hematopoietic stem cell transplantation (Chin Med J (Engl) 2008;121:1766)
● Occurs in 10% of pediatric bone marrow transplants (J Pediatr Urol 2009;5:254)
Clinical features
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● Irritative voiding symptoms, gross hematuria
Prognostic factors
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Case reports
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● 49 year old man with symptoms after receiving penicillin for endocarditis (Intern Med 2009;48:1667)
Treatment
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● Clot evacuation and hydration (eMedicine); rarely requires cystectomy
Clinical images
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Gross description (Macroscopy)
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Gross images
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Hemorrhagic Cystitis
Hemorrhagic and edematous cystitis
Urothelial carcinoma with marked hemorrhagic and edematous cystitis #1; #2
Hemorrhagic cystitis with fiery red mucosa, due to Citrobacter cultured repeatedly during life
No thumbnail: hemorrhagic and ulcerative cystitis after cyclophosphamide
Micro description (Histopathology)
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Micro images
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Cytology description
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Cytology images
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Positive stains
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Negative stains
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Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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● Hemorrhage associated with malignancy
Additional references
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End of Bladder > Cystitis > Hemorrhagic cystitis
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