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CD Markers
CD3

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 21 August 2013, last major update August 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.

General
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Pathophysiology
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Clinical features
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Uses by pathologists
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Micro images
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Tonsil (normal)



Staining of tumor cells:

Breast: high grade peripheral T cell lymphoma

Liver: hepatosplenic gamma-delta
T cell lymphoma (fig A)


Lymph node: nodal CD8+ cytotoxic T cell lymphoma

Nose (left), testis (right): NK/T cell lymphoma, nasal type


Pleural effusion:
primary effusion lymphoma
T cell type (fig B)

Skin: mycosis fungoides

Thymoma: lymphocyte predominant



Staining of nonneoplastic infiltrating T cells:

Bladder: lymphoepithelioma-like carcinoma (left side)


CNS: primary diffuse large B cell lymphoma

Esophagus diffuse large B cell lymphoma

Eye: ocular adnexal mantle cell lymphoma


Lymph node: nodular lymphocyte predominant Hodgkin Lymphoma

Lymph node: nodal hamartoma


Myeloid sarcoma


Skin: diffuse large B cell lymphoma (fig C)

Skin: halo nevus

Skin: Jessnerís lymphocytic infiltration



Inflammatory disorders - staining of T cells:

Duodenum: intraepithelial lymphocytes left (fig b), right (fig c, d)

Myocardium: acute cellular rejection

Skin graft rejection


Thyroid: Hashimoto thyroiditis (fig c, e , f)



Negative controls / no T cells identified:

Stomach: MALT lymphoma

Thyroid: MALT lymphoma is CD3- (fig d)

Positive staining - normal
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Positive staining - disease
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Negative staining
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Flow cytometry description
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Flow cytometry images
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Soft tissue: anaplastic large cell lymphoma

Virtual slides
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Diffuse large B cell lymphoma (CD3+ reactive T cells)

End of CD Markers > CD3


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