CD Markers
CD38

Author: Nat Pernick, M.D. (see Authors page)

Revised: 30 December 2015, last major update January 2011

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD38 [title]
Definition / General
  • Multifunctional enzyme whose ligand is CD31
Terminology
  • Also known as ADP-ribosyl cyclase 1
Pathophysiology
  • Synthesizes cyclic ADP-ribose, a second messenger for glucose induced insulin secretion
  • Appears to regulate cellular levels of NAD in multiple tissues and cells (Curr Pharm Des 2009;15:57)
  • Regulates intracellular calcium (Physiol Rev 2008;88:841)
  • Positive and negative regulator of cell activation and proliferation, depending on the cellular environment
  • Involved in adhesion between human lymphocytes and endothelial cells
  • Considered an activation marker
  • May cause physiologic death of T cell precursors in human thymus (Int Immunol 2003;15:1105)
Clinical Features
Uses by Pathologists
  • Identify plasma cells and plasmablastic differentiation
  • Diagnosis of myeloma
  • Prognosis for CLL patients (presence on 30% or more B-CLL cells by flow cytometry is associated with poor prognosis (Leukemia 2005;19:750)
Positive Staining - Normal
Positive Staining - Disease
Negative Staining
Additional References