CD Markers
CD38



Topic Completed: 01 January 2011

Revised: 14 December 2018, last major update January 2011

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD38 [title]
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Cite this page: Pernick N. CD38. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd38.html. Accessed January 22nd, 2019.
Definition / general
  • Multifunctional enzyme whose ligand is CD31
Terminology
  • Also known as ADP-ribosyl cyclase 1
Pathophysiology
  • Synthesizes cyclic ADP-ribose, a second messenger for glucose induced insulin secretion
  • Appears to regulate cellular levels of NAD in multiple tissues and cells (Curr Pharm Des 2009;15:57)
  • Regulates intracellular calcium (Physiol Rev 2008;88:841)
  • Positive and negative regulator of cell activation and proliferation, depending on the cellular environment
  • Involved in adhesion between human lymphocytes and endothelial cells
  • Considered an activation marker
  • May cause physiologic death of T cell precursors in human thymus (Int Immunol 2003;15:1105)
Clinical features
Uses by pathologists
  • Identify plasma cells and plasmablastic differentiation
  • Diagnosis of myeloma
  • Prognosis for CLL patients (presence on 30% or more B-CLL cells by flow cytometry is associated with poor prognosis (Leukemia 2005;19:750)
Positive staining - normal
Positive staining - disease
Negative staining
Additional references