CD Markers

Author: Nat Pernick, M.D. (see Authors page)

Revised: 7 January 2016, last major update January 2011

Copyright: (c) 2002-2016,, Inc.

PubMed Search: CD47[title]

Related: CD47R (below)

Cite this page: CD47. website. Accessed October 25th, 2016.
Definition / General
  • Modulates cell adhesion
  • Also called integrin associated protein (IAP), antigenic surface determinant protein OA3
  • Expression on tumor cells may block phagocytosis by macrophages; anti-CD47 antibodies are being studied as combination treatment with rituximab (Cell 2010;142:699)
  • CD47 on tumor cells is accompanied by calreticulin, a pro-phagocytic marker (Sci Transl Med 2010;2:63ra94)
  • Reduced CD47 expression on monocytes is associated with burn severity and the occurrence of multiple organ dysfunction syndrome/MODS in burn patients (Burns 2009;45:937)
  • CD47 / thrombospondin-1 have a role in cardiovascular pathology through their interaction with nitric oxide (Arterioscler Thromb Vasc Biol 2008;28:615)
  • Helps maintain mechanical properties of RBC membrane (Leuk Lymphoma 2004;45:1319)
  • References: OMIM #601028
Uses by Pathologists
Positive Staining - Normal
  • All hematopoietic cells, brain, endothelial cells, epithelial cells, fibroblasts and mesenchymal cells
Positive Staining - Disease

Definition / General
  • New designation for CDw149
  • Similar distribution as CD47 but dimmer
  • Poorly characterized, with little information available
  • Also called Rh related antigen
  • Previously CDw149
Uses by Pathologists
  • No significant clinical use by pathologists
Positive Staining - Normal
  • Lymphocytes, monocytes, neutrophils (weak), eosinophils (weak) and platelets (weak)
Negative Staining
  • Erythrocytes