General
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• Modulates cell adhesion
• Also called integrin associated protein (IAP), antigenic surface determinant protein OA3
• Expression on tumor cells may block phagocytosis by macrophages; anti-CD47 antibodies are being studied as combination treatment with rituximab (Cell 2010;142:699)
• CD47 on tumor cells is accompanied by calreticulin, a pro-phagocytic marker (Sci Transl Med 2010;2:63ra94)
• Reduced CD47 expression on monocytes is associated with burn severity and the occurrence of multiple organ dysfunction syndrome/MODS in burn patients (Burns 2009;45:937)
• CD47 / thrombospondin-1 have a role in cardiovascular pathology through their interaction with nitric oxide (Arterioscler Thromb Vasc Biol 2008;28:615)
• Helps maintain mechanical properties of RBC membrane (Leuk Lymphoma 2004;45:1319)
• References: OMIM #601028

Uses by pathologists
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• Measure storage related changes in red blood cells (Transfusion 2005;45:1496)
• Differentiate T-acute lymphoblastic leukemia (CD47+) from T-lymphoblastic lymphoma (CD47-, Pediatr Blood Cancer 2006;47:130)

Positive staining - normal
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• All hematopoietic cells, brain, endothelial cells, epithelial cells, fibroblasts and mesenchymal cells

Positive staining - disease
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• Acute lymphoblastic leukemia (Cancer Res 2011;71:1374), acute myelogenous leukemia (Cell 2009;138:286), bladder carcinoma, non-Hodgkin's lymphoma and ovarian tumors

General
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• New designation for CDw149
• Similar distribution as CD47 but dimmer
• Poorly characterized, with little information available
• Also called Rh related antigen
• Previously CDw149

Physiology
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• Recognizes a clustered subset of CD47 (Tissue Antigens 2000;56:258)

Uses by pathologists
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• No significant clinical use by pathologists

Positive staining - normal
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• Lymphocytes, monocytes, neutrophils (weak), eosinophils (weak) and platelets (weak)

Negative staining
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• Erythrocytes

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