Pathology Outlines

CD Markers
CD47

Author: Nat Pernick, M.D. (see Authors page)

Revised: 7 January 2016, last major update January 2011

Copyright: (c) 2002-2016, PathologyOutlines.com, Inc.

PubMed Search: CD47[title]

Related: CD47R (below)

Table of Contents

Definition / General

Modulates cell adhesion
Also called integrin associated protein (IAP), antigenic surface determinant protein OA3
Expression on tumor cells may block phagocytosis by macrophages; anti-CD47 antibodies are being studied as combination treatment with rituximab (Cell 2010;142:699)
CD47 on tumor cells is accompanied by calreticulin, a pro-phagocytic marker (Sci Transl Med 2010;2:63ra94)
Reduced CD47 expression on monocytes is associated with burn severity and the occurrence of multiple organ dysfunction syndrome/MODS in burn patients (Burns 2009;45:937)
CD47 / thrombospondin-1 have a role in cardiovascular pathology through their interaction with nitric oxide (Arterioscler Thromb Vasc Biol 2008;28:615)
Helps maintain mechanical properties of RBC membrane (Leuk Lymphoma 2004;45:1319)
References: OMIM #601028

Uses by Pathologists

Measure storage related changes in red blood cells (Transfusion 2005;45:1496)
Differentiate T-acute lymphoblastic leukemia (CD47+) from T-lymphoblastic lymphoma (CD47-, Pediatr Blood Cancer 2006;47:130)

Positive Staining - Normal

All hematopoietic cells, brain, endothelial cells, epithelial cells, fibroblasts and mesenchymal cells

Positive Staining - Disease

Acute lymphoblastic leukemia (Cancer Res 2011;71:1374), acute myelogenous leukemia (Cell 2009;138:286), bladder carcinoma, non-Hodgkin's lymphoma and ovarian tumors

CD47R

Definition / General

New designation for CDw149
Similar distribution as CD47 but dimmer
Poorly characterized, with little information available
Also called Rh related antigen
Previously CDw149

Pathophysiology

Recognizes a clustered subset of CD47 (Tissue Antigens 2000;56:258)

Uses by Pathologists

No significant clinical use by pathologists

Positive Staining - Normal

Lymphocytes, monocytes, neutrophils (weak), eosinophils (weak) and platelets (weak)

Negative Staining

Erythrocytes