CD Markers

Topic Completed: 1 January 2011

Revised: 14 December 2018, last major update January 2011

Copyright: (c) 2002-2016,, Inc.

PubMed Search: CD47[title]

Related: CD47R (below)

Nat Pernick, M.D.
Page views in 2018: 187
Page views in 2019 to date: 298
Cite this page: Pernick N. CD47. website. Accessed December 11th, 2019.
Definition / general
  • Modulates cell adhesion
  • Also called integrin associated protein (IAP), antigenic surface determinant protein OA3
  • Expression on tumor cells may block phagocytosis by macrophages; anti-CD47 antibodies are being studied as combination treatment with rituximab (Cell 2010;142:699)
  • CD47 on tumor cells is accompanied by calreticulin, a pro-phagocytic marker (Sci Transl Med 2010;2:63ra94)
  • Reduced CD47 expression on monocytes is associated with burn severity and the occurrence of multiple organ dysfunction syndrome/MODS in burn patients (Burns 2009;45:937)
  • CD47 / thrombospondin-1 have a role in cardiovascular pathology through their interaction with nitric oxide (Arterioscler Thromb Vasc Biol 2008;28:615)
  • Helps maintain mechanical properties of RBC membrane (Leuk Lymphoma 2004;45:1319)
  • References: OMIM #601028
Uses by pathologists
Positive staining - normal
  • All hematopoietic cells, brain, endothelial cells, epithelial cells, fibroblasts and mesenchymal cells
Positive staining - disease

Definition / general
  • New designation for CDw149 (CD149) which was deleted at the 7th HLDA Workshop (Tissue Antigens 2000;56:258)
  • Similar distribution as CD47 but dimmer
  • Poorly characterized, with little information available
  • Also called Rh related antigen
  • Previously CDw149
Uses by pathologists
  • No significant clinical use by pathologists
Positive staining - normal
  • Lymphocytes, monocytes, neutrophils (weak), eosinophils (weak) and platelets (weak)
Negative staining
  • Erythrocytes
Back to top