Table of Contents
Definition / general | Uses by pathologists | Positive staining - normal | Positive staining - disease | Definition / general | Pathophysiology | Uses by pathologists | Positive staining - normal | Negative stainingCite this page: Pernick N. CD47. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd47.html. Accessed April 20th, 2019.
Definition / general
- Modulates cell adhesion
- Also called integrin associated protein (IAP), antigenic surface determinant protein OA3
- Expression on tumor cells may block phagocytosis by macrophages; anti-CD47 antibodies are being studied as combination treatment with rituximab (Cell 2010;142:699)
- CD47 on tumor cells is accompanied by calreticulin, a pro-phagocytic marker (Sci Transl Med 2010;2:63ra94)
- Reduced CD47 expression on monocytes is associated with burn severity and the occurrence of multiple organ dysfunction syndrome/MODS in burn patients (Burns 2009;45:937)
- CD47 / thrombospondin-1 have a role in cardiovascular pathology through their interaction with nitric oxide (Arterioscler Thromb Vasc Biol 2008;28:615)
- Helps maintain mechanical properties of RBC membrane (Leuk Lymphoma 2004;45:1319)
- References: OMIM #601028
Uses by pathologists
- Measure storage related changes in red blood cells (Transfusion 2005;45:1496)
- Differentiate T-acute lymphoblastic leukemia (CD47+) from T-lymphoblastic lymphoma (CD47-, Pediatr Blood Cancer 2006;47:130)
Positive staining - normal
- All hematopoietic cells, brain, endothelial cells, epithelial cells, fibroblasts and mesenchymal cells
Positive staining - disease
- Acute lymphoblastic leukemia (Cancer Res 2011;71:1374), acute myelogenous leukemia (Cell 2009;138:286), bladder carcinoma, non-Hodgkin's lymphoma and ovarian tumors
CD47R
Definition / general
- New designation for CDw149 (CD149) which was deleted at the 7th HLDA Workshop (Tissue Antigens 2000;56:258)
- Similar distribution as CD47 but dimmer
- Poorly characterized, with little information available
- Also called Rh related antigen
- Previously CDw149
Pathophysiology
- Recognizes a clustered subset of CD47 (Tissue Antigens 2000;56:258)
Uses by pathologists
- No significant clinical use by pathologists
Positive staining - normal
- Lymphocytes, monocytes, neutrophils (weak), eosinophils (weak) and platelets (weak)
Negative staining
- Erythrocytes
