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CD Markers
CD8

Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 31 August 2013, last major update August 2013
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
PubMed Search: CD8[title]

General
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Physiology
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Diagrams
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CD8+ T cell activation requires 2 signals

Clinical features
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Uses by pathologists
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Micro images
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Various-quality control

Bladder: follicular cystitis (fig D)

Blood: T cell granular lymphocytic leukemia

Cervix: lymphoepithelioma
-like carcinoma (fig 3)


Duodenum: intraepithelial lymphocytes (left: fig 1c; right: fig 2e)

Lymph node: nodal CD8+ cytotoxic T cell lymphoma


Skin: cutaneous CD8+ epidermotropic T cell lymphoma

Skin: lymphomatoid papulosis (fig B, C)

Skin: mycosis fungoides (fig B, D)

Soft tissue: subcutaneous panniculitis-like T cell lymphoma


Splenic hamartoma (left) sinus lining cells are CD8+ compared to splenic littoral cell angioma (right), where lining cells are CD8-


Positive staining - normal
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Positive staining - disease
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Negative staining
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Flow cytometry images
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Anaplastic large cell lymphoma: partial CD4 & CD8 coexpression

End of CD Markers > CD8


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