Inflammation of cervix
Chlamydia trachomatis

Author: Branko Perunovic, M.D. (see Authors page)

Revised: 31 March 2017, last major update May 2007

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed search: Chlamydia trachomatis cervix

Cite this page: Chlamydia trachomatis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixchlamydia.html. Accessed July 20th, 2017.
Definition / general
  • Most common sexually transmitted disease (STD) in Western world; 4 million new cases annually in US
  • Affects cervix, uterus, adnexae; not vulva/vagina
  • Chlamydia trachomatis is an obligate intracellular parasite with elementary bodies (infectious but incapable of cell division) and reticulate bodies (multiply within cytoplasm, but not infectious until they transfer back into elementary bodies)
  • Causes infertility
  • Diagnose based on culture, PCR of urine or enzyme immunoassay on cervical / urethral swab (Arch Pathol Lab Med 2000;124:840)
  • Nucleic acid amplification of urine has similar sensitivity as samples from cervix or urethra (Ann Intern Med 2005;142:914)
  • Does NOT cause dysplasia
Microscopic (histologic) description
  • Lymphoid germinal centers (follicular cervicitis - sensitive but not specific for chlamydia), plasma cells, reactive epithelial atypia
Cytology description
Positive stains
  • Immunocytochemistry can detect organisms