Eye
Conjunctiva
Graft versus host disease

Author: Deepali Jain, M.D. (see Authors page)

Revised: 18 April 2018, last major update March 2013

Copyright: (c) 2004-2018, PathologyOutlines.com, Inc.

PubMed Search: Graft versus host disease conjunctiva

Cite this page: Jain, D. Conjunctiva: graft versus host disease. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/eyeGVHDconjunctiva.html. Accessed August 20th, 2018.
Definition / general
  • Occurs in up to 80% of chronic graft versus host disease patients with allogeneic hematopoietic transplants
  • Most commonly affects conjunctiva, lacrimal gland, meibomian glands; also cornea, choroid
  • Bulbar conjunctiva is biopsied for diagnosis
  • Conjunctival and lacrimal gland fibrosis may be due to epithelial mesenchymal transition (Am J Pathol 2009;175:2372)
  • Modified Lerner classification of bulbar GVHD seems to have prognostic value (Graefes Arch Clin Exp Ophthalmol 2007;245:1001)
Microscopic (histologic) description
Microscopic (histologic) images

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Chronic GVHD

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Excessive fibrosis

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Basal epithelial cell invasion

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Epithelial mesenchymal transition

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Epithelial mesenchymal transition

Cytology description
  • Conjunctival scrape cytology:
Electron microscopy images

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Disrupted basal lamina and epithelial cells

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Myoepithelial cell invasion