Leukemia - Acute - AML with pseudo-Chèdiak-Higashi anomaly

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Leukemia - Acute

AML not otherwise categorized

AML with pseudo-Chèdiak-Higashi anomaly

Reviewer: Daniela Mihova, M.D. (see Reviewers page)
Revised: 20 March 2013, last major update September 2012
Copyright: (c) 2001-2013, PathologyOutlines.com, Inc.

General
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● Not part of WHO classification
● Frequent in acute promyelocytic leukemia; up to 25% of AML-M2 (Acta Paediatr Jpn 1990;32:651)
● Giant granules may be due to fusion of primary granules or small dense vesicles
● See also Bone marrow-nonneoplastic chapter

Case reports
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● 16 year old girl with AML-M5a and t(10;11) (Clin Lab Haematol 2000;22:303)

Micro description
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● Giant cytoplasmic granules

Micro images
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Specific granules resemble Chediak-Higashi anomaly

In blast cells in AML-M2 patients

Giant inclusion bodies in bone marrow of patient with Chediak-Higashi syndrome, for comparison

Positive stains
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● CD2 (Am J Clin Pathol 2006;125:791)

Molecular description
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● May be associated with double minutes (Leukemia 2002;16:152)

Electron microscopy description
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● Peroxidase positive granules with a dense matrix but no obvious crystalline structure, may contain membranous lamellae or tubular structures (Cancer Res 1980;40:4473, Sangre (Barc) 1994;39:135)

End of Leukemia - Acute > AML not otherwise categorized > AML with pseudo-Chèdiak-Higashi anomaly

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