Leukemia - Acute
AML not otherwise categorized
AML with pseudo-Chèdiak-Higashi anomaly
Reviewer: Daniela Mihova, M.D. (see Reviewers page)
Revised: 20 March 2013, last major update September 2012
Copyright: (c) 2001-2013, PathologyOutlines.com, Inc.
● Not part of WHO classification
● Frequent in acute promyelocytic leukemia; up to 25% of AML-M2 (Acta Paediatr Jpn 1990;32:651)
● Giant granules may be due to fusion of primary granules or small dense vesicles
● See also Bone marrow-nonneoplastic chapter
● 16 year old girl with AML-M5a and t(10;11) (Clin Lab Haematol 2000;22:303)
● Giant cytoplasmic granules
Specific granules resemble Chediak-Higashi anomaly
In blast cells in AML-M2 patients
Giant inclusion bodies in bone marrow of patient with Chediak-Higashi syndrome, for comparison
● CD2 (Am J Clin Pathol 2006;125:791)
● May be associated with double minutes (Leukemia 2002;16:152)
Electron microscopy description
● Peroxidase positive granules with a dense matrix but no obvious crystalline structure, may contain membranous lamellae or tubular structures (Cancer Res 1980;40:4473, Sangre (Barc) 1994;39:135)
End of Leukemia - Acute > AML not otherwise categorized > AML with pseudo-Chèdiak-Higashi anomaly
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