Home   Chapter Home   Jobs   Conferences   Fellowships   Books



Advertisement

Leukemia - Acute

AML not otherwise categorized

AML with pseudo-Chèdiak-Higashi anomaly


Reviewer: Daniela Mihova, M.D. (see Reviewers page)
Revised: 20 March 2013, last major update September 2012
Copyright: (c) 2001-2013, PathologyOutlines.com, Inc.

General
=========================================================================

● Not part of WHO classification
● Frequent in acute promyelocytic leukemia; up to 25% of AML-M2 (Acta Paediatr Jpn 1990;32:651)
● Giant granules may be due to fusion of primary granules or small dense vesicles
● See also Bone marrow-nonneoplastic chapter

Case reports
=========================================================================

● 16 year old girl with AML-M5a and t(10;11) (Clin Lab Haematol 2000;22:303)

Micro description
=========================================================================

● Giant cytoplasmic granules

Micro images
=========================================================================


       
Specific granules resemble Chediak-Higashi anomaly


In blast cells in AML-M2 patients


Giant inclusion bodies in bone marrow of patient with Chediak-Higashi syndrome, for comparison

Positive stains
=========================================================================

● CD2 (Am J Clin Pathol 2006;125:791)

Molecular description
=========================================================================

● May be associated with double minutes (Leukemia 2002;16:152)

Electron microscopy description
=========================================================================

● Peroxidase positive granules with a dense matrix but no obvious crystalline structure, may contain membranous lamellae or tubular structures (Cancer Res 1980;40:4473, Sangre (Barc) 1994;39:135)

End of Leukemia - Acute > AML not otherwise categorized > AML with pseudo-Chèdiak-Higashi anomaly


This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.

All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com with any questions (click here for other contact information).