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Roche pan-TRK (EPR17341) IHC IVD Assay

Copyright: 2020, PathologyOutlines.com, Inc.

Revised: 9 September 2020

For information about Roche Diagnostics, visit diagnostics.roche.com or call 1-800-428-5076.

* This library contains material produced by Roche which has not been peer reviewed by PathologyOutlines.com.
* Pathologists should contact Dr. Pernick (Nat@PathologyOutlines.com) to suggest additional material to add to this page.

* For comprehensive information on the VENTANA pan-TRK IHC IVD assay, including training resources and an assay interpretation guide, visit go.roche.com/NTRKIHC

“Down the Ocular” – Webcast – Listen to Dr. Bharathi Vennapusa discuss various topics related to NTRK gene fusion testing methodologies and recommendations for stratifying patients with IHC testing prior to NGS confirmation.

Videos available on YouTube:



Part 1: Biology and Testing methods for NTRK fusions
Dr. Denise Croix with Roche Diagnostics Medical and Scientific Affairs (MSA) provides an overview of the function and role pan-TRK IHC plays in testing methodology for NTRK gene fusions.

  • NTRK overview
  • Gene fusions
  • Prevalence
  • Methods of detection

Part 2: Pan-TRK IHC with VENTANA pan-TRK IHC (EPR17341) Assay
Dr. Bharathi Venapussa, a pathologist with Roche Diagnostics Medical and Scientific Affairs (MSA), discusses:.

  • Biology of NTRK fusions
  • IHC testing methodology
  • Staining patterns
  • Assay validation
  • Disease states
  • Challenges

Part 3: Pan-TRK testing algorithms
Dr. Katie Robertson with Roche Diagnostics Medical and Scientific Affairs (MSA) discusses multiple testing algorithms for the detection of NTRK fusion positive cancer.

  • Overview
  • Testing algorithms
    • ESMO recommendation
    • MSKCC recommendation
    • NCCN guidelines

Interpretation of VENTANA pan-TRK (EPR17341) Assay – Digital Case Review
Dr. Bharathi Vennapusa from Roche MSA reviews example cases stained with VENTANA pan-TRK (EPR17341) Assay using digital slides. Content and approvals of any product related information is current as of the date of publishing.


    Related PathologyOutlines.com resources: NTRK stain topic
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