Liver and intrahepatic bile ducts - nontumor
Biliary tract disease
Secondary biliary cirrhosis

Topic Completed: 1 May 2012

Revised: 7 November 2019

Revised: 23 January 2019, last major update May 2012

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Secondary biliary cirrhosis[TI]

Komal Arora, M.D.
Page views in 2018: 1,679
Page views in 2019 to date: 2,225
Cite this page: Arora K. Secondary biliary cirrhosis. website. Accessed November 22nd, 2019.
Definition / general
  • Extrahepatic bile duct obstruction due to biliary atresia, choledochal cysts, cystic fibrosis, Alagille syndrome, gallstones, postsurgical stricture, carcinoma of pancreatic head or biliary tree
  • Symptoms and laboratory: same as primary biliary cirrhosis but no antimitochondrial antibodies
  • Secondary inflammation causes periportal fibrosis, scarring and nodule formation
Gross description
  • Yellow green, icteric discoloration of tissues and fluids
  • Hard, granular liver
Microscopic (histologic) description
  • Fibrosis divides liver into jigsaw-like pattern
  • Septa contain large and small bile ducts with inspissated pigment
  • Extensive proliferation of bile ductules and edema, particularly at interface of septa and parenchyma
  • May have bile lakes, extensive feathery degeneration
Back to top