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Liver and intrahepatic bile ducts-nontumor

Biliary tract disease

Secondary biliary cirrhosis


Reviewers: Komal Arora, M.D. (see Reviewers page)
Revised: 15 May 2012, last major update May 2012
Copyright: (c) 2004-2012, PathologyOutlines.com, Inc.

General
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● Extrahepatic bile duct obstruction due to biliary atresia, choledochal cysts, cystic fibrosis, Alagille’s syndrome, gallstones, post-surgical stricture, carcinoma of pancreatic head or biliary tree
Symptoms and laboratory: same as primary biliary cirrhosis, but no antimitochondrial antibodies
● Secondary inflammation causes periportal fibrosis, scarring and nodule formation

Gross description
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● Yellow-green, icteric discoloration of tissues and fluids
● Hard, granular liver

Micro description
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● Fibrosis divides liver into jigsaw-like pattern
● Septa contain large and small bile ducts with inspissated pigment
● Extensive proliferation of bile ductules and edema, particularly at interface of septa and parenchyma
● May have bile lakes, extensive feathery degeneration

End of Liver and intrahepatic bile ducts-nontumor > Biliary tract disease > Secondary biliary cirrhosis


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