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Oral cavity


Hairy leukoplakia

Reviewer: Patricia DeVilliers, D.D.S., M.S. (see Reviewers page)
Revised: 1 October 2012, last major update August 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.


● White, confluent patches of fluffy (hairy) mucosa, bilateral, along lateral tongue
● Associated with HIV+ patients (AIDS may appear within 2-3 years), but actually due to EBV infection

Micro description

● Hyperkeratotic oral mucosa due to piling of keratotic squamous epithelium
● Cowdry type A intranuclear inclusions
● Balloon cells with margination of chromatin (nuclear beading); EBV present in clear cells of spinous layer
● Variable koilocytosis, superimposed Candida infection, without inflammatory response

Electron microscopy

● Herpes type virions

End of Oral cavity > Infectious > Hairy leukoplakia

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