Ovary - nontumor
Nonneoplastic cysts / other
Large solitary luteinized follicular cyst of pregnancy and puerperium

Author: Shahid Islam, M.D. (see Authors page)

Revised: 19 September 2017, last major update June 2012

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PubMed Search: Large solitary luteinized follicular cyst of pregnancy and puerperium

Cite this page: Islam, S. Large solitary luteinized follicular cyst of pregnancy and puerperium. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/ovaryLSLFC.html. Accessed December 12th, 2017.
Definition / general
  • Rare solitary follicular cyst that occurs during pregnancy and puerperium, may be related to hCG
  • Palpable adnexal mass or seen at C section
  • No clinical endocrine disturbance
Treatment
Gross description
  • Large, solitary, unilocular cyst, resembles follicular cyst but markedly larger (median size - 25 cm)
Gross images

Images hosted on PathOut server:

25 cm unilocular cyst

Microscopic (histologic) description
  • Cyst lined by 1 or more layers of luteinized cells with clear to pink cytoplasm, no theca / granulosa distinction
  • Focal nuclear atypia (enlarged, pleomorphic and hyperchromatic nuclei) is probably degenerative
  • Also nests of luteinized cells within fibrous tissue of cyst wall (Pathol Res Pract 2006;202:471)
  • May have a few mitotic figures (Diagn Pathol 2011;6:3)
Microscopic (histologic) images

Images hosted on other servers:

Various images


Various images contributed by Dr. Raul Gonzalez, Vanderbilt University (USA)

Differential diagnosis
  • Cystic ovarian neoplasm (low N/C ratio, sporadic atypia and clinical setting favor a solitary follicular cyst)