Ovary - nontumor
Large solitary luteinized follicular cyst of pregnancy and puerperium
Reviewer: Shahid Islam, M.D., (see Reviewers page)
Revised: 5 June 2012, last major update June 2012
Copyright: (c) 2002-2012, PathologyOutlines.com, Inc.
● Rare solitary follicular cyst that occurs during pregnancy and puerperium, may be related to hCG
● Palpable adnexal mass or seen at C-section
● No clinical endocrine disturbance
● Conservative, most regress during puerperium, may need to excise if symptomatic
(Obstet Gynecol 2005;105:1218)
● Large, solitary, unilocular cyst, resembles follicular cyst, but markedly larger (median size - 25 cm)
25 cm unilocular cyst
● Cyst lined by 1 or more layers of luteinized cells with clear to pink cytoplasm, no theca/granulosa distinction
● Focal nuclear atypia (enlarged, pleomorphic and hyperchromatic nuclei) is probably degenerative
● Also nests of luteinized cells within fibrous tissue of cyst wall (Pathol Res Pract 2006;202:471)
● May have a few mitotic figures (Diagn Pathol 2011 Jan 10;6:3)
Luteinized cyst wall (fig c)
● Cystic ovarian neoplasm (low N/C ratio, sporadic atypia and clinical setting favor a solitary follicular cyst)
● Am J Surg Pathol 1980;4:431,
Arch Pathol Lab Med 1986;110:928
End of Ovary - nontumor > Non-neoplastic cysts/other > Large solitary luteinized follicular cyst of pregnancy and puerperium
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