Penis and scrotum - Papillomatosis of glans corona

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Penis and scrotum

Inflammatory lesions

Pearly penile papules

Reviewers: Antonio Cubilla, M.D. and Alcides Chaux, M.D. (see Author/Reviewers page)

Revised: 20 February 2010, last major update February 2010

Definition

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● Benign condition of 20-30% of normal young and middle-aged males, asymptomatic

Terminology

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● Also called hirsutoid papillomas, papillomatosis of glans corona

Epidemiology

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● Prevalence of 38% in men < 25 years old and 11% in men >50 years old (Int J STD AIDS 2009;20:768)

Etiology

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● Hyperplastic, reactive

● Not related to HPV (J Am Acad Dermatol 2003;49:50)

Clinical features

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● Multiple pearly gray, white fibroepithelial papillomas, 1-2 mm, in dorsal glans corona

● Usually arranged in 2-3 rows

● Rarely covers most of glans

● Reduced prevalence in circumcised men

● Has been confused with Tyson’s glands, which don’t exist in humans (Wikipedia)

Treatment

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● None required; disappears with age; CO2 laser if patients request removal (Dermatol Surg 2002;28:617)

● Also cryotherapy, electrodesiccation,podophyllin or curettage

Clinical images

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AFIP Fig 10-84: regular rows of small Small papillary lesions 1-2 cm papules

papules form a ring around the corona

Micro description (Histopathology)

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● Hyperkeratosis associated with a fibrovascular stroma, simulating an angiofibroma

● No koilocytosis, no significant inflammation

Micro images

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Benign epithelial hyperplasia with vascular fibrous stroma

Differential Diagnosis

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● Condyloma acuminatum: nonuniform, not arranged in rows, has HPV related changes

● Syphilis: ulcer with indurated and punched out base, marked plasmacytic inflammation, serologic evidence of syphilis

End of Penis and scrotum > Inflammatory Lesions > Papillomatosis of glans corona

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