Skin nonmelanocytic tumor
Lymphoma and related disorders (see also Lymphoma chapter)
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Langerhans cell histiocytosis


Topic Completed: 1 September 2012

Minor changes: 15 October 2020

Copyright: 2003-2020, PathologyOutlines.com, Inc.

PubMed search: langerhans cell histiocytosis [title] cutaneous skin

Christopher S. Hale, M.D.
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Cite this page: Hale CS. Langerhans cell histiocytosis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/skintumornonmelanocyticLCH.html. Accessed October 24th, 2020.
Definition / general
  • Solitary or multiple lesions (papules, nodules, plaques) containing Langerhans cells
  • Also called Histiocytosis X
  • Langerhans cells are derived from bone marrow, circulate freely from skin to regional lymph nodes
  • In infants, clinically resembles seborrheic keratosis
  • Interleukin-17 (IL17) from lesional dendritic cells may drive Langerhans cell proliferation (Nat Med 2008;14:81) but data not conclusive (Mol Ther 2011;19:1433)
Case reports
Clinical images

Images hosted on other servers:

Brown lichenoid patches

Microscopic (histologic) description
  • Diffuse dermal infiltrate of Langerhans cells (large, ovoid, pale pink cytoplasm, indented bland nuclei) or
  • Clusters of Langerhans cells which resemble granulomas or
  • Dermal infiltrate of cells with more foamy cytoplasm
Microscopic (histologic) images

Contributed by Mark R. Wick, M.D.

CD1a

Langerin

S100



Contributed by Asmaa Gaber Abdou, M.D.

Various images



Images hosted on other servers:

CD1a, S100

Electron microscopy description
  • Birbeck granules (resemble lollipops) next to nuclear membrane
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