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Skin - Nonmelanocytic tumors

Other tumors of skin

Xanthoma

Reviewer: Christopher Hale, M.D. (see Reviewers page)
Revised: 18 September 2012, last major update September 2012
Copyright: (c) 2001-2012, PathologyOutlines.com, Inc.

General
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● Non-neoplastic
● Often periarticular; also trunk or extremities of males
● Associated with hyperlipidemia (primary or secondary to diabetes, hypothyroidism, myeloma, lymphoma, leukemia, obstructive liver disease)

Eruptive xanthoma:
● Abrupt onset of crops of yellow papules with erythematous halos on extremities, which wax and wane with triglyceride and cholesterol levels

Plane xanthoma:
● Linear yellow lesions in skinfolds, including palmar creases
● Associated with primary biliary cirrhosis

Tuberous/tendinous xanthoma:
● Yellow nodules on Achilles tendon and extensor tendons of fingers

Verruciform xanthoma:
● Papillomatous, verruca-like change of overlying epidermis

Xanthelasma:
● Soft yellow papules and plaques in eyelid
● Some cases lack lipid abnormalities

Gross description
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● Nodules

Micro description
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● Fat-laden histiocytes in dermis or subcutis
● Also in tendons, synovium and bone

End of Skin - Nonmelanocytic tumors > Other tumors of skin > Xanthoma

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