Neuron specific enolase (NSE)
Reviewer: Kara Hamilton, M.S., Nat Pernick, M.D. (see Reviewers page)
Revised: 20 July 2013, last major update June 2009
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
- Cytoplasmic enzyme expressed by neuroendocrine cells and tumors, including poorly differentiated neuroendocrine tumors, which usually are negative for other neuroendocrine markers
- Despite its name, is often not specific for neuroendocrine cells / tumors
- Enolases are widely distributed glycolytic enzymes that catalyze the interconversion of 2-phosphoglycerate and phosphophenolpyruvate
- NSE refers to the gamma-gamma and alpha-gamma isoenzymes preferentially found in neurons and neuroendocrine cells
Positive staining - normal
- Neurons, neuroendocrine cells
Positive staining - disease
- Neuroectodermal and neuroendocrine neoplasms
End of Stains > Neuron specific enolase (NSE)
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