Author: Nat Pernick, M.D. (see Authors page)

Revised: 3 November 2015, last major update November 2013

Copyright: (c) 2003-2015,, Inc.

PubMed Search: alpha-1-antichymotrypsin[title]
  • Also called α1-ACT
  • Acute phase protein / plasma protease inhibitor, mainly produced by liver in response to cytokines such as oncostatin M
  • May limit tissue damage produced by excessive inflammation associated proteolysis
  • Also localizes to nuclei of hepatic cells to control chromatin condensation and proliferation (Gastroenterology 2013;144:818)
  • Homologous to alpha-1-antitrypsin
  • Chymotrypsin is digestive enzyme produced by pancreas
Clinical Features
Uses by Pathologists
Micro Images

Images hosted on other servers:

Breast: primary acinic cell carcinoma (fig F)

Pancreas: pancreatoblastoma (fig C)

Skin: nevi and melanoma

Stomach: hepatoid
adenocarcinoma (fig C)

Positive Staining - Normal
  • Histiocytes, reticulum cells
Positive staining - Tumors
  • Acinic / acinar cell carcinomas of breast, pancreas, salivary gland tumors
  • Hepatoid adenocarcinoma of stomach (World J Gastroenterol 2013;19:4437)
  • Solid-pseudopapillay neoplasm of pancreas