Stains
HLA-DR (Ia)

Author: Nat Pernick, M.D. (see Authors page)

Revised: 1 December 2015, last major update April 2013

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: HLA-DR [title]

Cite this page: HLA-DR (Ia). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainshladr.html. Accessed December 7th, 2016.
Definition / General
  • HLA-DR is a MHC (major histocompatibility complex) class II cell surface receptor encoded by human leukocyte antigen complex on 6p21.31 (Wikipedia - HLA-DR)
  • Antigen presenting cells use HLA-DR molecules to present protein fragments (processed antigen) to T cells, a key event in induction of T cell responses (PLoS One 2012;7:e31483)
Clinical Features
Diagrams / Tables

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DR with bound ligand

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DR receptor

Micro Images

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Cervix, squamous cell carc, FA

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Diffuse large B cell lymphoma

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Skin, atopic eczema lesions

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Skin scar

Positive Staining - Normal
  • Basophils (immature), osteoblasts
  • Antigen presenting cells (B cells, dendritic cells, macrophages, monocytes)
  • Precursor T cells and CD4+ T cells
  • Liver, bile ductules
  • Thymus
Positive Staining - Disease
  • AML: M0-M6 (some variability)
    • Also AML with myelodysplastic related changes, recurrent genetic abnormalities
    • Acute basophilic leukemia, acute panmyelosis with myelofibrosis, transient myeloproliferative disorder of Down's syndrome (80%)
  • Breast: medullary carcinoma
  • Esophagus: Crohn's disease
  • Langerhans cell histiocytosis
  • Lymphomas:
    • Adult T cell leukemia / lymphoma (HTLV1+, frequent)
    • B-ALL
    • Blastic plasmacytoid dendritic cell neoplasm
    • Extranodal NK/T-cell lymphoma nasal type
    • Primary effusion
    • SLL / CLL
  • Thyroid: Grave disease (thyrocytes and lymphocytes)
Negative Staining