Stains
Lysozyme


Topic Completed: 1 June 2012

Revised: 6 March 2019

Copyright: 2003-2018, PathologyOutlines.com, Inc.

PubMed Search: lysozyme[title]

Nat Pernick, M.D.
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Page views in 2019 to date: 1,433
Cite this page: Pernick N. Lysozyme. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainslysozyme.html. Accessed October 13th, 2019.
Definition / general
Microscopic (histologic) images

Images hosted on PathOut server:

Orbit: myeloid sarcoma

Thyroid gland:
histiocytes stain
strongly in
palpation thyroiditis



Images hosted on other servers:

Acute myelomonocytic leukemia (M4)

Vagina: myeloid sarcoma

Positive staining - normal
  • Nonspecific stain for histiocytes (granulomas), monocytes, neutrophils
  • May also stain some epithelial cells (pleomorphic adenoma)
  • Goblet cells and related lesions (goblet cell carcinoid)
  • Breast lactating lobules
Positive staining - disease
  • Acinic cell carcinoma (breast, salivary gland, Am J Surg Pathol 2009;33:1137)
  • Acute myelomonocytic leukemia (M4), acute monocytic leukemia (M5)
  • Adenocarcinoma (various sites)
  • Ampulla: Paneth cell carcinoma
  • CNS: chordoma
  • Eye: oncocytoma of conjunctiva
  • Histiocytic lesions: histiocytoma, histiocytic sarcoma, Rosai Dorfman disease
  • Langerhans cell histiocytosis
  • Mastocytosis
  • Myeloid sarcoma
  • Renal collecting duct / Bellini duct carcinoma
  • Salivary gland intercalated duct lesions (Am J Surg Pathol 2009;33:1322)
  • Skin: granuloma annulare, multicentric reticulohistiocytosis, synovial metaplasia, xanthogranuloma
  • Spleen: angiosarcoma and hemangioma (often, Mod Pathol 2000;13:978), littoral cell angioma
Negative staining
  • Breast: histiocytoid variant of lobular carcinoma
  • Dendritic cells
  • Inflammatory pseudotumor
  • Interdigitating dendritic cell sarcoma
  • Skin: necrobiosis lipoidica
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