Stains
NapsinA

Author: Nat Pernick, M.D. (see Authors page)

Revised: 23 July 2018, last major update June 2012

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: Napsin A

Cite this page: Pernick, N. NapsinA. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsnapsina.html. Accessed August 14th, 2018.
Definition / general
  • A novel aspartic proteinase of the pepsin family involved in the maturation of surfactant protein B
  • Found primarily in lung and kidney
  • Lack of NapsinA expression in tumor cells may be poor prognostic marker in pulmonary adenocarcinoma (Lung Cancer 2012;77:156)
Uses by pathologists
Microscopic (histologic) images

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Lung adenocarcinoma, compared with TTF1

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Lung adenocarcinoma


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Cerebellar tumor specimen

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Lung squamous cell carcinoma

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Various images

Cytology images

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Pulmonary ADC

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Pulmonary SCC

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SCC

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ADC


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PDC

Positive staining - normal
Positive staining - disease
Electron microscopy images

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Type II pneumocytes