NPM-ALK fusion protein

Author: Nat Pernick, M.D. (see Authors page)

Revised: 16 November 2015, last major update June 2005

Copyright: (c) 2002-2015,, Inc.

PubMed Search: NPM-ALK fusion protein [title]

Table of Contents
Definition / General
Definition / General
  • Formed by consistent breakpoints in t(2;5)(p23;q35)
  • Has truncated NPM and ALK proteins
  • Contains only constitutively active catalytic domain of ALK
  • Fusion protein found in anaplastic large cell lymphoma (13 - 50%)
    • When present, can be used to differentiate from Hodgkin lymphoma
  • Patients with fusion protein appear to have better prognosis
  • Appears to phosphorylate / activate members of multiple signaling pathways influencing cell proliferation and apoptosis, including ras, Grb2, Shc, IRS-1, JAK / STAT, PI3-kinase / AKT and FOX03a