NPM-ALK fusion protein
Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 10 September 2013, last major update June 2005
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PubMed Search: NPM-ALK fusion protein[title]
- Formed by consistent breakpoints in t(2;5)(p23;q35); has truncated NPM and ALK proteins
- Contains only constitutively active catalytic domain of ALK
- Fusion protein found in anaplastic large cell lymphoma (13-50%); when present, can be used to differentiate from Hodgkin’s lymphoma
- Patients with fusion protein appear to have better prognosis
- Appears to phosphorylate/activate members of multiple signaling pathways influencing cell proliferation and apoptosis, including ras, Grb2, Shc, IRS-1, JAK/STAT, PI3-kinase/AKT and FOX03a
End of Stains > NPM-ALK fusion protein
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