Stains
NPM-ALK fusion protein



Topic Completed: 1 June 2005

Revised: 7 March 2019

Copyright: 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: NPM-ALK fusion protein [title]
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Definition / general
Cite this page: Pernick N. NPM-ALK fusion protein. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsnpmalk.html. Accessed March 24th, 2019.
Definition / general
  • Formed by consistent breakpoints in t(2;5)(p23;q35)
  • Has truncated NPM and ALK proteins
  • Contains only constitutively active catalytic domain of ALK
  • Fusion protein found in anaplastic large cell lymphoma (13 - 50%)
    • When present, can be used to differentiate from Hodgkin lymphoma
  • Patients with fusion protein appear to have better prognosis
  • Appears to phosphorylate / activate members of multiple signaling pathways influencing cell proliferation and apoptosis, including ras, Grb2, Shc, IRS-1, JAK / STAT, PI3-kinase / AKT and FOX03a
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