Author: Nat Pernick, M.D.

Revised: 10 October 2018, last major update November 2011

Copyright: (c) 2002-2018,, Inc.

PubMed Search: PAX8 stain

Cite this page: Pernick, N. PAX8. website. Accessed October 17th, 2018.
Definition / general
  • Also called Paired box 8
  • Discovered in 1990 (Development 1990;110:643)
  • Paired domains are composed of two helix-turn-helix subdomains
    • The N-terminal subdomain and the C-terminal subdomain, both of which can bind DNA independently (Cell 1995;80:639)
  • Structurally similar to PAX2 and PAX5
  • Nuclear staining
  • Actually negative in B cell lymphomas, but reported positive due to cross reactivity between the N-terminal regions of PAX8 and PAX5, due to the high sequence homology of these two regions (Mod Pathol 2012;25:231)
Uses by pathologists
Microscopic (histologic) images

Images hosted on PathOut server:

Contributed by Andrey Bychkov, M.D., Ph.D.:

Ovarian cancer

Thyroid follicular cells

Papillary thyroid carcinoma

Images hosted on other servers:
Missing Image


Positive staining - normal
  • Epithelium of endocervix, endometrium, fallopian tubes, kidney (glomerular parietal epithelial cells, renal collecting ductal cells, atrophic renal tubular epithelial cells, Mod Pathol 2011;24:751), thyroid
  • Ovarian inclusion cysts, pancreatic islet cells
  • Epithelium of male genital tract from rete testis to ejaculatory duct, but not prostate
Positive staining - disease
Negative staining