Stains & molecular markers

Topic Completed: 1 November 2011

Minor changes: 8 September 2020

Copyright: 2002-2020,, Inc.

PubMed Search: PAX8 stain

Nat Pernick, M.D.
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Cite this page: Pernick N. PAX8. website. Accessed September 21st, 2020.
Definition / general
  • Also called Paired box 8
  • Discovered in 1990 (Development 1990;110:643)
  • Paired domains are composed of two helix-turn-helix subdomains
    • The N-terminal subdomain and the C-terminal subdomain, both of which can bind DNA independently (Cell 1995;80:639)
  • Structurally similar to PAX2 and PAX5
  • Nuclear staining
  • Actually negative in B cell lymphomas, but reported positive due to cross reactivity between the N-terminal regions of PAX8 and PAX5, due to the high sequence homology of these two regions (Mod Pathol 2012;25:231)
Uses by pathologists
Microscopic (histologic) images

Contributed by Andrey Bychkov, M.D., Ph.D.:

Ovarian cancer

Thyroid follicular cells

Papillary thyroid carcinoma

Positive staining - normal
  • Epithelium of endocervix, endometrium, fallopian tubes, kidney (glomerular parietal epithelial cells, renal collecting ductal cells, atrophic renal tubular epithelial cells, Mod Pathol 2011;24:751), thyroid
  • Ovarian inclusion cysts, pancreatic islet cells
  • Epithelium of male genital tract from rete testis to ejaculatory duct, but not prostate
Positive staining - disease
Negative staining
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