Stains
PAX8

Author: Nat Pernick, M.D. (see Authors page)

Revised: 2 December 2015, last major update November 2011

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: PAX8 [title]

Definition / General
  • Also called Paired box 8
  • Discovered in 1990 (Development 1990;110:643)
  • Paired domains are composed of two helix-turn-helix subdomains
    • The N-terminal subdomain and the C-terminal subdomain, both of which can bind DNA independently (Cell 1995;80:639)
  • Structurally similar to PAX2 and PAX5
Pathophysiology
Interpretation
  • Nuclear staining
  • Actually negative in B cell lymphomas, but reported positive due to cross-reactivity between the N-terminal regions of PAX8 and PAX5, due to the high sequence homology of these two regions (Mod Pathol 2012;25:231)
Uses by Pathologists
Micro Images

Images hosted on Other servers:

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Kidney



Nature images:

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Normal adult kidney

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Renal epithelial tumors

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Thyroid carcinomas

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Urothelial carcinoma

Positive Staining - Normal
  • Epithelium of endocervix, endometrium, fallopian tubes, kidney (glomerular parietal epithelial cells, renal collecting ductal cells, atrophic renal tubular epithelial cells, Mod Pathol 2011;24:751), thyroid
  • Ovarian inclusion cysts, pancreatic islet cells
  • Epithelium of male genital tract from rete testis to ejaculatory duct, but not prostate
Positive Staining - Disease
Negative Staining