Author: Nat Pernick, M.D. (see Authors page)

Revised: 15 December 2015, last major update March 2013

Copyright: (c) 2002-2015,, Inc.

PubMed Search: PTEN [title]

Definition / General
  • Phosphatase and tensin homologue deleted on chromosome Ten (at 10q23)
  • Tumor suppressor gene commonly lost in human cancer
  • Has important role in cell cycle regulation and apoptosis
  • Produces a dual-specific lipid phosphatase that negatively regulates protein kinase-B/AKT activity by dephosphorylating phosphatidylinositol-triphosphate (PI3)
Diagrams / Tables
Clinical Features
Uses by Pathologists
  • Loss of nuclear PTEN expression in adenomatous thyroid nodules is sensitive and specific for Cowden syndrome (Am J Surg Pathol 2011;35:1505)
  • Loss of cytoplasmic PTEN may distinguish intraductal prostatic carcinoma from high grade PIN (Mod Pathol 2013;26:587)
Micro Images

Images hosted on Other servers:

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Colon, carcinoma and adenoma

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Uterus, endometrial carcinoma

Nature images:

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Liver, cholangio-

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Stomach, adenocarcinoma

Positive Staining - Normal
  • Found in almost all body tissue
Positive Staining - Disease
  • Various carcinomas
Negative Staining
  • Frequent loss of expression in carcinoma