Author: Nat Pernick, M.D. (see Authors page)

Revised: 4 December 2015, last major update June 2005

Copyright: (c) 2003-2015,, Inc.

PubMed Search: RET[title]

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Cite this page: RET. website. Accessed January 22nd, 2019.
Definition / general
  • Gene at 10q11.2
  • Receptor tyrosine kinase expressed in neural crest cells
  • RET ligand is glial-derived neurotrophic factor
  • Activating mutations in 90% of patients with MEN 2A and 2B and FMTC (familial medullary thyroid carcinoma)
  • Inactivating mutations in Hirschsprung's disease
  • RET/PTC gene arrangement is common in papillary thyroid carcinoma; also seen in Hashimoto’s thyroiditis
  • Includes RET/PTC1 (60-70%), RET/PTC3 (20-30%)
  • Rare families have FMTC & Hirschsprung's, perhaps due to tissue-specific modifiers
Additional references