Stains
STAT6


Topic Completed: 18 February 2019

Revised: 18 February 2019

Copyright: 2018-2019, PathologyOutlines.com, Inc.

PubMed Search: STAT6[TI] pathology free full text[sb]

Alison Lavinia Cheah, M.B.B.S.
Page views in 2018: 12
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Cite this page: Satgunaseelan L, Cheah AL. STAT6. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/stainsstat6.html. Accessed September 23rd, 2019.
Definition / general
  • Signal transducer and activator of transcription (STAT) 6
  • Member of STAT transcription factor family
  • In physiological state, cytokine stimulation and tyrosine phosphorylation of cytoplasmic STAT6 leads to transfer of STAT6 to nucleus for transcriptional roles in proliferation and immune regulation (Am J Clin Pathol 2015;143:672)
Essential features
Pathophysiology
  • NAB2 (NGFI-A binding protein 2) represses transcription, while STAT6 influences gene expression by DNA promoter binding
  • NAB2-STAT6 fusion results from an intrachromosomal inversion on 12q13 locus
  • NAB2-STAT6 fusion gene acts as activator of EGR1 (early growth response 1) targeted transcription and relocates to the nucleus, with resultant strong nuclear expression of STAT6 by immunohistochemistry (Mod Pathol 2014;27:390, Am J Clin Pathol 2015;143:672)
Clinical features
Interpretation
  • Nuclear stain
Uses by pathologists
  • Distinction of solitary fibrous tumor (positive staining) from histological mimics (negative staining)
Prognostic factors
Microscopic (histologic) images

Contributed by Alison Lavinia Cheah, M.B.B.S.

Solitary fibrous tumor (buccal mucosa)

Solitary fibrous tumor, giant cell angiofibroma variant (thigh)

Malignant solitary fibrous tumor (mediastinum)

Positive staining - normal
Positive staining - tumors
Negative staining - normal
Negative staining - tumors
Molecular / cytogenetics description
Board review question #1
Which of the following acts as the fusion partner for STAT6 in solitary fibrous tumor?

  1. EWSR1
  2. MDM2
  3. NAB2
  4. NCOA2
  5. NR4A3
Board review answer #1
C. NAB2. NAB2-STAT6 fusion occurs secondary to an intrachromosomal inversion of the 12q13 locus, resulting in the fusion protein which relocates to the nucleus.

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