Thyroid gland
Hyperplasia / goiter
Endemic goiter

Author: Shahidul Islam, M.D., Ph.D. (see Authors page)

Revised: 19 January 2017, last major update March 2009

Copyright: (c) 2003-2017, PathologyOutlines.com, Inc.

PubMed Search: thyroid endemic goiter
Cite this page: Endemic goiter. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/thyroidendemicgoiter.html. Accessed April 24th, 2017.
Definition / General
  • Goiter associated with iodine deficiency in particular geographic locations, usually distant from the sea
  • Endemic if prevalence is greater than 5 - 10%
  • Iodine supplementation reduces its frequency, but may increase prevalence of autoimmunity (Hormones (Athens) 2007;6:25)
Epidemiology
Etiology
  • May be exacerbated by goitrogens, such as cassava and cruciferous vegetables, or sewage contamination of water
  • May also be due to high iodine intake (Am J Public Health 2000;90:1633)
Clinical Images

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Endemic goiter

Gross Description
  • Multiple nodules with degenerative changes of fibrosis, old and new hemorrhage (similar to multinodular goiter)
Micro Description
  • Follicles of varying size, thin follicular cells
Additional References