Bone & joints


Secondary osteosarcoma

Topic Completed: 1 August 2013

Minor changes: 13 January 2021

Copyright: 2003-2019,, Inc.

PubMed Search: Paget disease associated osteosarcoma

Nat Pernick, M.D.
Page views in 2020: 560
Page views in 2021 to date: 446
Cite this page: Pernick N. Secondary osteosarcoma. website. Accessed October 27th, 2021.
Definition / general
  • Usually associated with polyostotic Paget disease
  • Multicentric tumors associated with increasing localized pain
  • Much older age than conventional osteosarcoma
  • Very poor prognosis, with death due to pulmonary metastasis or local extension
  • Sites: pelvis, humerus, femur, tibia, skull
Radiology description
  • Paget disease and destruction
Radiology images

Contributed by Dr. Mark R. Wick

CT scan


Gross images

Contributed by Dr. Mark R. Wick
Microscopic (histologic) description
  • High grade sarcoma (osteosarcoma, fibrosarcoma, malignant fibrous histiocytoma) with osteoclasts and atypical osteoblasts
Microscopic (histologic) images

AFIP images
Missing Image

Osteosarcoma arising in Paget disease

Contributed by Dr. Mark R. Wick

Paget disease of bone with secondary osteosarcoma

Additional references
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