Contributed by Chunlai Zuo, M.D., M.S. and Huihui Ye, M.D., M.S.
Bladder wall mass by CT
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Bladder neck mass by ultrasound
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Bladder neck tumor cystoscopy
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Primary signet ring
cell carcinoma of
upper urinary tract
Adenocarcinoma of urinary bladder
Contributed by Chunlai Zuo, M.D., M.S. and Huihui Ye, M.D., M.S.
Villoglandular growth
Cytologic atypia
Desmoplastic reaction
Intraluminal mucin
Muscularis propria invasion
Signet ring cells
Mucin pool
Malignant glandular epithelium
Intestinal / enteric type
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Vacuolated cells
Penile metastasis
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Abnormal FISH
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Development of bladder
Position of bladder in female pelvis
Interior
Position of bladder in male pelvis
Contributed by @Andrew_Fltv on Twitter
Contributed by @Andrew_Fltv on Twitter (see original post here)">
Arteriovenous malformation
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Many eosinophils
Contributed by Sean R. Williamson, M.D. and Bhavesh Papadi, M.D. (Case #331)
Ureter CIS
Denuded urothelium
Various images
Additional images
Contributed by @AnaPath10 on Twitter
Bladder carcinoma in situ
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H&E
Loss of polarization
Broadened urothelium
Narrowed urothelium
Pagetoid pattern
Histopathology Bladder Transitional Carcinoma in situ
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Cystoscopy
Contributed by Jonathan Epstein, M.D.
Prostatic urethra papillary lesion
Urinary bladder hyperplastic lesion
Urinary bladder koilocytosis
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T1 weighted MRI
Transabdominal ultrasound
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Cystoscopy
Contributed by Maria Tretiakova, M.D., Ph.D.
Cystitis cystica
Cystitis glandularis
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Urine cytology
Contributed by Bonnie Choy, M.D.
High grade urothelial carcinoma
High grade urothelial carcinoma
Low grade urothelial neoplasia
Squamous cell carcinoma
Small cell carcinoma
Prostatic adenocarcinoma
NKX3.1
Colorectal adenocarcinoma
Renal cell carcinoma
Contributed by Bonnie Choy, M.D.
Acute bacterial infection
Candida
Polyomavirus
Human papilloma virus
Schistosoma
Trichomonas
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Image with case history
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Cystourethrogram shows complete bladder duplication
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Pathogenesis of bladder cancer
Contributed by Moe Thuzar, M.D. and Y. Albert Yeh, M.D., Ph.D.
Loss of polarity
Nuclear enlargement and hyperchromasia
Decreased urothelial thickness
Hyperplastic atypical urothelium
Urothelial atypia
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Prostatic glands with luminal secretion underlying urothelium (right: PSA+)
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CT scan shows gas in bladder and bladder wall
CT scan of 77 year old woman without diabetes
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Linear calcifications
Irregular calcifications
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Multiple thin calcifications
Contributed by Bohdan Zoshchuk, M.D. and Y. Albert Yeh, M.D., Ph.D.
Dystrophic calcifications
Encrusted calcifications
Encrusted necrotic debris
Encrusted calcified fragments
Calcified plaques
Calcifications and chronic inflammation
Encrustations and fibrin
Calcifying encrustations
Calcifications and giant cells
Calcifications in fibrotic stroma
Calcium salts
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Calcifying nanoparticles
Contributed by Jian-Hua Qiao, M.D.
Inflammatory infiltrate with marked eosinophils
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Diagrams of exstrophy
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Exstrophy in male infants
Contributed by Dr. Jesus Chavez and Dr. Debra Zynger
Urethra and periurethral tissue
Contributed by Dr. Jesus Chavez and Dr. Debra Zynger
High power, low grade
Noninvasive high grade
Invasive high grade
Necrosis and keratinization
Elderly woman: metastatic
Clear cell adenocarcinoma
Low power, prominent necrosis
Can mimic nephrogenic metaplasia
With hobnailing
With prominent clear cells and diffuse, sheet-like growth
Case #194
Various images
CK7
p53
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Cystoscopy
Ureteral polyp
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Polyp of ureter
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Bladder biopsies
Follicular cystitis
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Numerous lymphocytes with varying maturity
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Granulomatous cystitis due to bCG treatment
Granulomatous cystitis, postresection
Postoperative granulomas, postresection
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Inflammatory bleeding bladder mucosa
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Hemorrhagic and ulcerative cystitis after cyclophosphamide
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Edema, bleeding and granulocyte infiltration
Hemorrhage and edema in the lamina propria
Case of the Week #353
47 year old man with herpes viral cytopathic effects in urine cytology
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Staging of bladder carcinoma
Contributed by Anil Parwani, M.D., Ph.D., M.B.A.
Bladder wall
Urothelium
von Brunn nests
Urothelium and lamina propria
Muscularis mucosa
Muscularis propria
Shotgun histology bladder
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White, gelatinous
mass with cystic
change brand
hemorrhage
AFIP images
Abundant thin walled vessels
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ALK1 expression
Focal inflammatory cells
Myofibroblastic cells
and inflammatory
cells in edematous
stroma
Spindle cells within fibromyxoid matrix and inflammatory cells
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Bladder CT
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Cystoscopic findings
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Inflamed mucosa
Contributed by Michelle R. Downes, M.D.
Hemorrhage and edema
Urothelial denudation and inflammation
Mixed inflammatory infiltrate
Surface ulceration
Inflammation,
microhemorrhages
and congestion
Hemorrhage and fibrosis
Contributed by Maria Tretiakova, M.D., Ph.D.
Replacement of urothelium
Without dysplastic changes
Formation of cystic spaces
GATA3
CK20
CK20
CK20
HMWCK
Contributed by Rugvedita Parakh, M.D.
Replacing urothelium
Surface goblet cells
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CT with bladder thickening
Bladder tumor and lung metastasis
Retrograde pyelogram
Pyeloureteral transitional cell
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Cystoscopy: pedunculated tumor
Contributed by Debra L. Zynger, M.D., Nicole K. Andeen, M.D. and Maria Tretiakova, M.D.
Muscularis propria invasion (pT2b)
Prostatic invasion (pT4a)
Renal pelvic and peripelvic fat invasion (pT3)
Friable, exophytic
papillary mass,
renal pelvis
Contributed by Maria Tretiakova, M.D., Ph.D., Andrey Bychkov, M.D., Ph.D., Nicole K. Andeen, M.D. and @katcollmd on Twitter
Invasive high grade urothelial carcinoma
Extensive invasion into lamina propria
Invasive urothelial
carcinoma with
comedo necrosis
Lymphovascular invasion
Muscularis propria invasion
IHC profile
Subepithelial invasion (pT1)
Invasion into muscularis (pT2)
Invasion of renal parenchyma (pT3)
Invasive urothelial carcinoma
Invasive urothelial carcinoma
Contributed by Bonnie Choy, M.D.
High grade urothelial carcinoma
Contributed by Nicole K. Andeen, M.D. and Maria Tretiakova, M.D.
Highly atypical cells
Large nuclei with high nuclear to cytoplasmic ratios, coarse chromatin and irregular nuclear contours (Papanicolaou and DiffQuik)
Contributed by Nicole K. Andeen, M.D. and Maria Tretiakova, M.D.
FISH, loss of 9p, normal disomy chromosomes 3, 7, 17
FISH, polyploidy chromosomes 3, 7, 17; 9p preserved
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Left ureter filling defect
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Tumor with smooth contour
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Polypoid mass
Contributed by Y. Albert Yeh, M.D., Ph.D., Daniel Athanazio, M.D., Ph.D. and Debra Zynger, M.D.
Smooth surface contour
Invagination of trabeculae
Interconnecting trabeculae and cords
Endophytic growth
Bland urothelial cells
Spindle urothelial cells
Central streaming / peripheral palisading
Focal mild reactive atypia
Inverted papilloma
Inverted papilloma - anastomosing cords
Thickened epithelium
Epithelium / no atypia
Inverted papilloma
Inverted papilloma - no atypia
Surface with thin, flat urothelium
Anastomosing, basophilic cords
Oval nuclei
Contributed by Daniel Anderson, M.D., M.B.A.
Solid growth
Necrosis and nuclear detail
Mitotic figures
CD56
Ki67
Synaptophysin
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Prominent nucleoli shown in pleural fluid
Contributed by Ankur Sangoi, M.D.
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Enhancing lesion from right renal pelvis
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Renal
pelvic tumor
invading parenchyma
and hilar fat
Contributed by Maria Tretiakova, M.D., Ph.D.
Syncytial growth, inflammation
Prominent nucleoli
Syncytial growth, prominent nucleoli
Syncytial growth, mitosis
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Endometriosis
Laparoscopic segmental cystectomy
AFIP images
Endosalpingiosis
Ovary: glands lined by ciliated epithelium lie in fibrous stroma
Ovary: ciliated,
secretory and
intercalated cells
line the cystic space
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Endocervicosis
Prominent
endocervical
glands in
muscularis propria
Complex cystic lesion
Columnar cells with granular mucinous apical cytoplasm
Endometriosis
Endometrial glands and
stroma involving the
peri-ureteral soft tissue
Contributed by Zachary Gordon, M.D., G. Bailey, M.D. and the Genitourinary Pathology Society (Case #496)
White light cystoscopy
Narrow band cystoscopy
Cystoscopic view of bladder lesions
Contributed by Cheng Wang, M.D. and the Genitourinary Pathology Society (Case #496)
Various images
PAS stain
Von Kossa stain
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Malakoplakia (arrows at Michaelis-Gutmann bodies)
von Kossa calcium stain
CD68
Contributed by Zachary Gordon, M.D.
White light cystoscopy
Narrow band cystoscopy
Contributed by Mustafa Goksel, M.D.
Sheets of eosinophilic histiocytes
Urinary bladder with histiocytic infiltration
Numerous intracytoplasmic inclusions
Von Kossa stain
Von Kossa stain
Contributed by Jesus Adrian Chavez, M.D. and Debra Zynger, M.D.
Penile urethra with periurethral involvement
Contributed by Jesus Adrian Chavez, M.D. and Debra Zynger, M.D.
Low grade noninvasive papillary urothelial carcinoma
Penile urethra, squamous cell carcinoma
Penile urethra, HPV+ high risk ISH
Necrosis and keratinization
Clear cell adenocarcinoma:
Can mimic nephrogenic metaplasia
With hobnailing
With prominent clear cells and diffuse, sheet-like growth
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Metastatic appendiceal
mucinous adenocarcinoma
- various images
Metastatic breast cancer: H&E, PR, HER2
Contributed by Bonnie Choy, M.D.
Prostatic adenocarcinoma
NKX3.1
Colorectal adenocarcinoma
Renal cell carcinoma
Contributed by Megan L. Brown, M.D. and Maria Tretiakova, M.D., Ph.D.
Microcysts, macrocysts and tubules
Invasion to muscularis propria
Cytokeratin 7
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CT with bladder tumor invading the left ureteral orifice
CT with tumor in right posterolateral bladder wall
Contributed by Timothy Isaac Miller, M.D., M.A., Maria Tretiakova, M.D., Ph.D. and @katcollmd on Twitter
Classic features
Micropapillary
and conventional
urothelial
carcinoma
Multiple nests throughout stroma
Epithelial ring morphology
Ring forms and intracytoplasmic vacuolization
Numerous nests in large lacunae
Micropapillary urothelial carcinoma
Micropapillary urothelial carcinoma
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Cohesive clusters in a 3 dimensional arrangement
Bladder urothelial carcinoma
Contributed by Jatin S. Gandhi, M.B.B.S., M.D., @MirunaPopescu13 on Twitter and @katcollmd on Twitter
With BCG granuloma
Peritubular basement membrane
With papillary architecture
Nephrogenic metaplasia
Nephrogenic metaplasia
PAX8+
HNF1 beta+
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Gray-white tumor
Contributed by Megan L. Brown, M.D., Maria Tretiakova, M.D., Ph.D. and @SueEPig on Twitter
von Brunn-like appearance
Irregular projections and occasional lumens
Invasion into muscularis propria
Large nested carcinoma
Nested urothelial carcinoma
Contributed by Michelle R. Downes, M.D., Nicole K. Andeen, M.D. and Maria Tretiakova, M.D.
Cystectomy section
Transurethral bladder resection
Cross section of ureter
Architecture and cytology
Cytologic features
Noninvasive papillary urothelial carcinoma, high grade (pTa)
CK7 expression
GATA3 expression
CK5/6 loss
p53
Contributed by Zeina Ghorab, M.D. and Bonnie Choy, M.D.
High grade cytology
High grade urothelial carcinoma
Urothelial carcinoma, papillary and invasive
Contributed by Michelle R. Downes, M.D., Nicole K. Andeen, M.D. and Maria Tretiakova, M.D.
Fibrovascular cores lined by neoplastic urothelium
Noninvasive papillary, low grade urothelial carcinoma
Papillary architecture
Architectural features
Endophytic growth pattern
GATA3
p53
Ki67
Noninvasive papillary urothelial carcinoma, low grade (pTa)
Papillary urothelial
carcinoma, absent
muscularis
Contributed by Zeina Ghorab M.D. and Bonnie Choy, M.D.
Cytology of
non high grade lesion
Low grade urothelial neoplasia
Urothelial carcinoma, papillary and invasive
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Exophytic lesion with internal vascularity
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Exophytic papillary - recurrent PUNLMP
Cystoscopy: exophytic papillary
Contributed by Daniel Athanazio, M.D., Ph.D.
Fresh specimen
Formalin fixed specimen
Contributed by Daniel Athanazio, M.D., Ph.D. and Luciana Schultz, M.D., Ph.D. (source: Instituto de Anatomia Patológica)
Exophytic intraluminal urothelial papillary neoplasm
Preserved polarity and no atypia
Thickened urothelium and hypercellularity
Thickened urothelium / no atypia
Papillary exophytic neoplasm
Preserved polarity and hypercellularity
Basally located mitosis
Transition zone between normal ureteral urothelium and a shoulder lesion
Endophytic / inverted growth
Exophytic and endophytic growth
Preserved polarity
Thickened epithelium / no atypia
Thickened epithelium / inverted growth
Thickened epithelium / inverted growth
Preserved polarity
Papillary exophytic
Thickened epithelium
No atypia
Papillary exophytic
Hypercellular monotonous urothelial lining
No atypia
Preserved polarity
GATA3
CK5
p16
Differential diagnosis of noninvasive endophytic urothelial neoplasms
PUNLMP at cytology
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Axial nonenhanced CT, Doppler ultrasound, MRI, PET
Axial contrast enhanced CT
Coronal contrast enhanced CT, MIBG scan
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Cystoscopic findings
Laparoscopic findings
Robot assisted laparoscopic findings
Contributed by Debra L. Zynger, M.D.
Partial cystectomy
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Partial cystectomy
Nephroureterectomy
Contributed by Theodorus H. van der Kwast, M.D., Ph.D., Michelle R. Downes, M.D., Debra L. Zynger, M.D. and David Cohen, M.B.B.Ch., M.D.
Transurethral bladder resection
Zellballen pattern
Typical cytologic features
Transurethral bladder resection
Zellballen pattern
Muscularis propria invasion
Transurethral bladder resection
Nuclear atypia
Zellballen pattern
Amphophilic cytoplasm
Pseudopapillary architecture
Cellular spindling
Mitotic activity
Muscularis propria invasion
Deep lamina propria invasion
Pseudocapsule
Typical cytologic features
Typical cytologic features
Synaptophysin
Chromogranin
GATA3
S100
SDHB retained
Pankeratin
p63
Chromogranin
Synaptophysin
S100
HMB45
Synaptophysin
GATA3
Contributed by Vaishali Pansare, M.D.
Adequacy of urine specimens
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Normal embryo at 25 - 27 days
Normal embryo at weeks 5 - 7
Diagram of persistent cloaca
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MRI of PUC with bladder muscle invasion
MRI and CT of PUC with peritoneal spread
CT of PUC with
peritoneal spread
and bladder wall
thickening
Contributed by Timothy Isaac Miller, M.D., M.A. and Maria Tretiakova, M.D., Ph.D.
Bladder with plasmacytoid urothelial carcinoma
Contributed by Timothy Isaac Miller, M.D., M.A., Nicole K. Andeen, M.D. and Maria Tretiakova, M.D., Ph.D.
PUC with carcinoma in situ
Muscularis propria involvement
Diffuse growth
Pleomorphic subvariant
Desmoplastic subvariant
Signet ring and classic morphologies
Lymphovascular invasion
Perineural invasion
PUC in bladder wall
PUC at urethral margin
AE1 / AE3
CD138
Contributed by Lisa Han, M.D. and Ricardo Lastra, M.D. (Case #510)
Urothelial carcinoma, plasmacytoid variant
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Bladder washing with PUC (Papanicolau stain, x400)
Plasmacytoid variant histology in bladder cancer
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Irregular wall thickening
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Tumor-like lesion
Contributed by Maria Carolina Beeter, M.D. and Y. Albert Yeh, M.D., Ph.D.
Polypoid mass
Inflammatory polypoid lesion
Nonneoplastic polypoid lesion
Polypoid lesion
Small cobblestone nodule
Small polypoid nodule
Fibrotic lamina propria
Somewhat fibrotic stroma
Polypoid papillary projections
Edematous polypoid lesion
Narrow to broad based papillae
Focal urothelial hyperplasia
Bullous lesion
Normal urothelial lining cells
Polypoid and papillary configuration
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Tumor of distal ureter
Case #339:
Various images
EMA
CK7
p53
GATA3
p63
SMA
S100
CD68
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Background mononuclear tumor cells
Osteoclast-like giant cell carcinoma
Osteoclast rich undifferentiated urothelial carcinoma
Cytoplasmic immunoreactivity with vimentin
Immunoreactivity with CD68
Focal immunoreactivity with AE1 / AE3
Nuclear immunoreactivity with Ki67
Nuclear immunoreactivity with p53
Osteoclast-like giant cells positive for CD68
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Diff Quick stain
Pap stain
Diff Quick stain
AFIP images
Interlacing fascicles of myofibroblasts
Uniform cells are mixed with inflammatory cells
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Left: muscularis
propria,
Right: spindle
cell nodule
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Smooth sessile mass on cystoscopy
Spherical mass on cystoscopy
Contributed by Bonnie Choy, M.D.
Polypoid
Admixture of urothelium and prostatic acini
Corpora amylacea
PSA positive
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Pathophysiology
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Bladder wall thickening
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Cystoscopy
Contributed by Y. Albert Yeh, M.D., Ph.D. and Jennifer Lee, M.D.
Telangiectatic vessels with fibrin
Dilated vessels with fibrin
Epithelial cells encircling fibrin
Urothelial cells enclosing fibrin
Atypical urothelial proliferation
Atypical urothelial proliferation
Fibrinoid vascular necrosis
Fibrin and proliferating cells
Fibrinoid necrosis of vessels
Mucosal hemorrhage and inflammation
Radiation induced urothelial changes
Atypical von Brunn nests
Stromal cell changes
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Radiation induced urothelial cell changes
Radiation induced urothelial reactive atypia
Contributed by Nicole K. Andeen, M.D. and Maria Tretiakova, M.D., Ph.D.
Mass involving hilum
Contributed by Megan L. Brown, M.D., Nicole K. Andeen, M.D., Maria Tretiakova, M.D., Ph.D. and Kenneth A. Iczkowski, M.D.
High grade spindled to epithelioid cells
Elongated spindled cells
Classic urothelial carcinoma
Neoplasm with admixed carcinomatous and sarcomatous elements
Osteosarcomatoid differentiation
GATA3 and CK7
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Life cycle
Contributed by Y. Albert Yeh, M.D., Ph.D., Susan Prendeville, M.D. and Kiran Alam, M.D., Anshu Jain, M.D.,
Veena Maheshwari, M.D., Farhan A. Siddiqui, M.B.B.S., Ershadul Haq, M.B.B.S., M.D. and @ThatGlassTho on Twitter
Calcified eggs and keratin
Schistosoma eggs and keratin
Schistosoma eggs with terminal spine
Bladder calcified eggs
Calcified eggs with cracks
Parasitic calcified eggs
Dysplastic keratinizing squamous cells
Malignant squamous cells
Malignant squamous cells with intercellular bridges
Schistosoma haematobium eggs
Schistosoma eggs in ureter
Ureter with Schistosoma eggs
Muscularis propria with Schistosoma eggs
Schistosoma eggs
Schistosomiasis (bilharziasis)
Contributed by Y. Albert Yeh, M.D., Ph.D.
Calcified eggs in urine
Schistosoma egg with lateral spine
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CT of bladder
CT of ureter
US of bladder
MRI of bladder
Gadolinium enhanced MRI of renal pelvis
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Right ureter mass
Renal pelvic lesion
Contributed by Reima El Naili, M.D.
Sheets of basophilic cells
Pleomorphism and nuclear molding
High N:C ratio
Brisk mitotic activity
Hemorrhage and atypical mitoses
Necrosis and Azzopardi effect
Mixed urothelial neuroendocrine carcinoma
Carcinoma with normal urothelium
CK AE1 / AE3
Synaptophysin
CD56
TTF1
Ki67
CD56 in mixed tumor
GATA3 in mixed tumor
INSM1
Contributed by Bonnie Choy, M.D.
Hypercellular specimen
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Bladder, Pap
Bladder small cell neuroendocrine carcinoma
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MRI bladder
Solitary mass lower right kidney
Mass in right renal pelvis
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Bladder exstrophy
Bladder
Contributed by Susan Prendeville, M.D.
specimen
Cross section of tumor
Ulcerating tumor
Renal pelvis
Contributed by Nicole K. Andeen, M.D.
Dilated renal calyces due to reflux
Solid, tannish white with central necrosis
Bladder
Contributed by Susan Prendeville, M.D.
Destructive stromal invasion
Irregular squamous nests
Keratin pearls
Prominent keratinization
Intercellular bridges
Poorly differentiated tumor
Squamous dysplasia / carcinoma in situ
Invading muscularis propria
Keratinizing squamous dysplasia
Schistosoma haematobium eggs
Renal pelvis
Contributed by Nicole K. Andeen, M.D.
Invasive tumor
Entrapped glomeruli
No urothelial differentiation
Individual cell keratinization
Entrapped renal tubules
Contributed by Susan Prendeville, M.D. and Bonnie Choy, M.D.
Malignant squamous cells
Keratinized malignant cells
Squamous cell carcinoma
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Cystoscopy finding: whitish exophytic lesion
Contributed by Harsh Batra, M.B.B.S., D.C.P., D.N.B. and Anil Parwani, M.D., Ph.D., M.B.A.
Transverse section of papillae
Transverse section through a single papilla
Fibrovascular cores
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Flaky, white, plaque-like lesions
Cystoscopy of trigone in 15 year old girl
Contributed by Maria Tretiakova, M.D., Ph.D.
Nonkeratinizing squamous metaplasia
Keratinizing squamous metaplasia with parakeratosis
Squamous metaplasia with cystitis glandularis
Keratinizing squamous metaplasia
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Benign squamous cells
Contributed by Debra L. Zynger, M.D.
Muscularis propria invasion (pT2b)
Prostatic invasion (pT4a)
Residual noninvasive tumor (ypTis / a)
Contributed by Debra L. Zynger, M.D.
Noninvasive low grade (pTa)
Microinvasion (pT1)
Lamina propria invasion (pT1)
Within muscularis mucosae (pT1)
Within muscularis propria (pT2)
Within perivesicular adipose (pT3)
Within prostate (pT4a)
Within prostate and prostatic glands (pT4a)
Lung metastasis (pM1b)
Uterus metastasis (pM1b)
Common iliac lymph node metastasis (pN3)
Contributed by Debra L. Zynger, M.D.
Penile urethral urothelial carcinoma (pT3)
Contributed by Debra L. Zynger, M.D.
Penile urethral urothelial carcinoma (pT3)
Contributed by Debra L. Zynger, M.D.
Renal pelvic and peripelvic fat invasion (pT3)
Contributed by Debra L. Zynger, M.D.
Renal parenchyma invasion (pT3)
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Various images
Postradiation changes mimic dysplasia
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Fetal tube connecting bladder with umbilicus
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Low attenuating cystic mass
Mass in the anterior abdominal wall
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Intraoperative image of cystic lesion at dome of bladder
Intraoperative image of urachal cyst
Intraoperative image of multilobulated cyst
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Excised specimen with umbilicus and neoplasm
Contributed by Maria Tretiakova, M.D., Ph.D.
Mucinous / colloid subtype
Enteric subtype
Signet ring subtype
Mixed subtype
Urachal carcinoma, NOS
Mucinous adenocarcinoma, bladder dome
CDX2 in bladder dome adenocarcinoma
CK20 in bladder dome adenocarcinoma
Beta catenin expression
High molecular weight cytokeratin expression
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FNAC smear of urachal adenocarcinoma
Mini tutorial of urachal tumors
Urachal adenocarcinoma diagnosis and treatment
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Persistent urachus
Before and after surgery
Urachal cysts - sinus tract between bladder dome and umbilicus
Infected urachal cyst
Urachal cyst attached to Meckel diverticulum
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Patent urachus, autopsy specimen
Benign urachal lesion
Infected urachal cyst and fibrous tract
Urachal cyst containing stones
Urachal sigmoid fistula
Inflamed urachal cyst
Contributed by Bohdan Zoshchuk, M.D. and Manasa Morisetti, M.D.
Patent urachus
Urachal remnant in bladder wall
Urachal remnant in bladder wall
Umbilical urachal sinus
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Persistent urachus
Before and after surgery
Urachal cysts - sinus tract between bladder dome and umbilicus
Infected urachal cyst
Urachal cyst attached to Meckel diverticulum
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Patent urachus, autopsy specimen
Benign urachal lesion
Infected urachal cyst and fibrous tract
Urachal cyst containing stones
Urachal sigmoid fistula
Inflamed urachal cyst
Contributed by Bohdan Zoshchuk, M.D. and Manasa Morisetti, M.D.
Patent urachus
Urachal remnant in bladder wall
Urachal remnant in bladder wall
Umbilical urachal sinus
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Continent urinary diversion using ileum
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Tubular adenoma with
high grade dysplasia
after augmentation
ileocystoplasty
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USG finding - solitary polypoid lesion
Lobulated soft-tissue mass
Contributed by Judy Sarungbam, M.D.
Discrete papillary structures
Slender fibrovascular core
Prominent umbrella cells
Edematous fibrovascular core
Contributed by Varsha Manucha, M.D.
Villous adenoma
Villous pattern
Nuclear stratification
Contributed by Maria Tretiakova, M.D., Ph.D.
Urothelial carcinoma
Clear cell (glycogen rich)
Giant cell
Lipid rich
Lymphoepithelioma-like
Microcystic / tubular
Poorly differentiated with osteoclast-like
giant cells
Trophoblastic differentiation
Contributed by Nicole K. Andeen, M.D. and Maria Tretiakova, M.D., Ph.D.
Various images
Images hosted on other servers:
T1 precontrast demonstrates isoechoic mass
Ultrasound shows mass-like hyperechoic area
Contributed by Huihui Ye, M.D., M.S.
Dome tumor
Posterior wall tumor
Contributed by Huihui Ye, M.D., M.S.
Basaloid features
Clear cell features
Nests of clear cells
Keratin pearls
Basaloid with central necrosis
Surface keratinization
Intercellular bridges
Contributed by Chunlai Zuo, M.D., M.S.
Squamous differentiation
Conventional urothelial carcinoma component
HGUC and necrosis
Images hosted on other servers:
High grade with squamous differentiation
Contributed by Anuradha Gopalan, M.D., Victor Reuter, M.D. and AFIP images
Multinucleated giant cells
hCG
GATA3
Amin: 2022
Cheng: 2019
Eble: 2022
Epstein: 2016
Haber: 2010
Hansel: 2018
IARC: 2022
Jim Zhai: 2015
Lopez-Beltran: 2016
Raspollini: 2019
VandenBussche: 2019
VandenBussche: 2022
Wobker: 2021
Wojcik: 2022
Yang: 2020
Zhou: 2022
Zhou: 2022
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