Prof. Dr. Fernando Schmitt:
The WHO System for Reporting Lung Cytopathology
Contributed by Reid Wilkins, M.D.
Overview of automation workflow
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ThinPrep imaging system
BD FocalPoint GS imaging system
Contributed by Xiaobing Jin, M.D., Ph.D. and Heather I-Hsuan Chen-Yost, M.D.
Bronchial cells
Bronchial cells cross section
Macrophages (ThinPrep)
Anthracosis
Hamartoma
(Diff-Quik)
Meningioma (Diff-Quik)
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Herpes inclusions
Cytomegalovirus (CMV)
Creola body
Contributed by Joseph D. Jakowski, M.D. and Susan Meanor, R.T., R.D.M.S.
Turkey phantom
Contributed by Lawrence Hsu Lin, M.D., Ph.D. and Tamar C. Brandler, M.D., M.S.
Serous fluid immunostain work up
Contributed by Lawrence Hsu Lin, M.D., Ph.D. and Tamar C. Brandler, M.D., M.S.
BerEP4 in pleural fluid
MOC31 in pleural fluid
GATA3 in pleural fluid
PAX8 in pleural fluid
NKX3.1 in ascites
TTF1 in pleural fluid
Napsin A in pleural fluid
p40 in ascites
CDX2 in ascites
Calretinin in ascites
D2-40 in ascites
WT1 in ascites
ER in pleural fluid
HER2 in pleural fluid
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BAP1 in mesothelioma
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p16 / CDKN2A deletion (FISH) in malignant mesothelioma
Absence of p16 / CDKN2A deletion by FISH
Contributed by Lawrence Hsu Lin, M.D., Ph.D. and Tamar C. Brandler, M.D., M.S.
Serous fluid cytology flow diagram
Contributed by Lawrence Hsu Lin, M.D., Ph.D. and Tamar C. Brandler, M.D., M.S.
Bloody specimen (ND)
Scant cellularity (ND)
Poor preservation (ND)
Reactive mesothelial cells (NFM)
Reactive mesothelial cells and histiocytes (NFM)
Collagen ball and mesothelial cells (NFM)
Endosalpingiosis (NFM)
Scant cell cluster with mild / moderate atypia (AUS)
Lymphocytic effusion (AUS)
Serous borderline tumor (AUS)
Few suspicious cells (SFM)
Highly atypical cell clusters with inflammation (SFM)
Highly atypical single cells (SFM)
Cell clusters with scalloped borders (MAL-P)
Highly atypical cluster of cells (MAL-P)
Cell cluster with smooth borders (MAL-S)
Highly atypical cell cluster (MAL-S)
Intracellular mucin (MAL-S)
Large atypical cells (MAL-S)
Contributed by Karen Villar Zarra, M.D.
Decision making in interventional pathology one stop clinic
Contributed by Karen Villar Zarra, M.D.
Automatic and manual trigger biopsy devices
Minimal percutaneous point of entry for core biopsies
Sample obtained with core biopsy devices
Ultrasound guided core biopsy - parallel approach
Different gauges of core biopsies from home made phantom
Contributed by Sadia Sayeed, M.D.
LSIL ThinPrep
HGSIL ThinPrep
HGSIL SurePath
Benign endocervical cells ThinPrep
Adenocarcinoma ThinPrep
Reactive mesothelial cells ThinPrep
Benign, BAL
HGUC, urine
Suspicious thyroid aspirate
Benign thyroid aspirate
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Left lower lobe mass
Contributed by Reima El Naili, M.D.
Squamous cell carcinoma
Prominent necrosis in small cell carcinoma
Cell block, adenocarcinoma
Adenocarcinoma
TTF1 in adenocarcinoma
p40 in adenocarcinoma
Squamous cell carcinoma
p40 in SCC
CK5/6 in SCC
TTF1 in SCC
Small cell carcinoma
Synaptophysin in small cell carcinoma
CD56 in small cell carcinoma
TTF1 in small cell carcinoma
CD45 in small cell carcinoma
Ki67 in small cell carcinoma
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FISH showing ALK rearrangement
Contributed by Mir Yousufuddin Ali Khan, M.D.
Obscuring blood
Alveolar macrophages
Fibrin thrombi
Bronchial cells
Crush artifact
Poor preservation and poor staining
Bronchial cells
Bronchial contamination
Pneumocytes
WHO reporting system for lung cytopathology
Adequacy criteria in EBUS FNA
Overview of lung cytopathology
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NGS analysis on smears
Ali: 2023
Bibbo: 2014
Bishop Pitman: 2015
Chandra: 2020
Cibas: 2020
DeMay: 2012
Faquin: 2023
Field: 2016
Field: 2020
IAC-IARC-WHO: 2023
IAC-IARC-WHO: 2023
Jiang: 2023
Layfield: 2018
Mody: 2022
Nayar: 2015
Ramzy: 2017
Shidham: 2021
VandenBussche: 2019
VandenBussche: 2022
Wojcik: 2022
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