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Papule on ear
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Acquired cholesteatoma
Contributed by Ashley Aiken, M.D.
CT, coronal
CT, axial
Contributed by Esther Vivas, M.D.
Mastoid cholesteatoma, right ear
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Bilateral congenital cholesteatoma
Congenital cholesteatoma
Acquired cholesteatoma
Contributed by Kelly Magliocca, D.D.S., M.P.H.
Fragments of hemorrhagic soft tissue
Contributed by Kelly Magliocca D.D.S., M.P.H.
Cholesteatoma epithelium and keratin
Fungal forms within keratin debris
Cholesteatoma eroding malleus
Cholesteatoma and middle ear mucosa
Cholesteatoma, inflamed
Cholesteatoma epithelium and keratin
Inflamed middle ear mucosa
Residual fibrous tissue and underlying cartilage
Middle ear mucosa with hyperplasia
Cuboidal middle ear epithelium
Keratinizing stratified squamous epithelium
Keratin granuloma within ossicular tissue
Primary and secondary acquired cholesteatoma
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Infiltration of papillary dermis by epithelioid (E) cells
External and middle ear
Contributed by Kelly Magliocca D.D.S., M.P.H.
Endolymphatic sac tumor, 2x
Endolymphatic sac tumor, 5x
Endolymphatic sac tumor, 15x
Endolymphatic sac tumor, 20x
Endolymphatic sac tumor, 40x
CAIX, 20x
PAX8, 40x
Negative RCC, 20x
Negative CD10, 20x
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Various images
Papilla with hemorrhagic material
Papilla with vacuolated cells and colloid-like material
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with soft tissue
density occupying
the middle ear
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glial tissue and
fibrovascular elements
GFAP+, S100+
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Central cystic degeneration of auricular cartilage
Factor VIII+ lining of pseudocyst
Contributed by Agnes Ikpoto Udoh, M.D., M.B.A.
Well circumscribed mass
Abundant mixed inflammation
Mixed inflammatory infiltrates within otic polyp
Otic polyp with giant cells
Mott cells
Abundant plasma cells
Infected aural polyp ear wax removal
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Keloid ultrasound appearance
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Keloids and hypertrophic scars
Contributed by Andrew Dettrick, M.B.B.S. and Ruta Gupta, M.D.
Raised dome with hairless surface
Cut surface
Contributed by Andrew Dettrick, M.B.B.S.
Dermal lesion
Edge of lesion
Keloidal collagen
Increased fibroblasts
Keloid scar:
5 minute pathology pearls
by Dr. Jerad Gardner
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Lipochoristoma of internal auditory canal
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Section through cochlea
Case #376
Various images
Chromogranin
Synaptophysin
Cytokeratin AE1 / 3
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Trabeculae and ribbons
Prominent glandular pattern
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Neurosecretory granules
Contributed by Kelly Magliocca D.D.S., M.P.H.
Middle ear paraganglioma, 4x
Middle ear paraganglioma, Zellballen
Synaptophysin positive in chief cells, 20x
S100 in sustentacular pattern, 40x
Case #349
H&E images
Contributed by Veena Maheshwar, M.D., Kiran Alam, M.D., Anshu Jain, M.D.
Various images
Contributed by Semir Vranic, M.D., Ph.D.
Angiolymphatic invasion
Cardesa: 2016
Franchi: 2020
Gnepp: 2021
IARC: 2024
Stelow: 2020
Thompson: 2022
Wenig: 2017
Wenig: 2024
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