Bladder
Congenital anomalies
Ectopic prostate

Author: Alcides Chaux, M.D. (see Authors page)

Revised: 8 March 2016, last major update April 2011

Copyright: (c) 2003-2016, PathologyOutlines.com, Inc.

PubMed Search: Ectopic prostate[title]
Definition / General
  • Prostatic-type glands within bladder mucosa
Epidemiology
  • Rare; < 50 cases reported
  • Usually in young males
Sites
  • Mainly at bladder neck but also trigone and interureteral ridge
  • Very rarely at retrotrigone and ureteral orifices
Etiology
  • Due to vestigial remains of embryonic prostate remnants, metaplasia in response to chronic inflammation or abnormal migration of undifferentiated embryonic prostatic tissue with hormonal stimulation during adult life (Int J Urol 2005;12:1066)
Clinical Features
  • May cause hematuria (most common symptom), dysuria, bladder outlet obstruction or persistent urinary tract infection
  • May simulate a neoplastic process
  • Benign behavior; no reported cases of malignant transformation
Case Reports
Treatment
  • Excision; may persist / recur if incomplete excision
Gross Description
  • Firm, smooth, dome-shaped, broad-based polypoid mass
  • Flat lesions also reported but very rare
Micro Description
  • Prostatic-like glands with luminal secretions beneath partially/totally denudated urothelium
  • May be associated with cystitis cystica and cystitis glandularis
  • Prostate-specific immunohistochemical markers are confirmatory but not mandatory
Micro Images

Images hosted on other servers:

Prostatic glands with luminal secretion underlying urothelium (right: PSA+)

Positive Stains
  • Glands: PSA, PAP
  • Basal layer: keratin 34betaE12
Differential Diagnosis