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Bladder
Congenital anomalies
Ectopic prostate
Author: Nat Pernick, M.D. (see Authors page)
Revised: 2 January 2010, last major update – January 2010
Copyright: (c) 2002-2010, PathologyOutlines.com, Inc.
Definition
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● Prostatic glands within bladder
Terminology
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Epidemiology
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● Rare; < 50 cases reported
Sites
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● Posterior urethra is common site
Etiology
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● Due to vestigial remains of embryonic prostate remnants (Int J Urol 2005;12:1066) or metaplasia
Clinical features
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● May cause hematuria, dysuria, bladder outlet obstruction or urinary tract infection
● Benign behavior; no reported cases of malignant transformation
Prognostic factors
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Case reports
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● 24 year old man with trigone mass (Indian J Urol 2008;24:564)
● 55 year old man with glands appearing to infiltrate bladder skeletal muscle (Cesk Patol 2001;37:65)
● 58 year old man with incidental finding (Actas Urol Esp 2002;26:369)
Treatment
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● Excision; may persist / recur if incomplete excision
Clinical images
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Gross description (Macroscopy)
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● polypoid mass at bladder base
Gross images
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Micro description (Histopathology)
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● Prostatic glands with luminal secretions beneath urothelium; prostatic stroma
Micro images
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Prostatic glands with luminal secretion underlying urothelium #1; #2-PSA+
Cytology description
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Cytology images
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Positive stains
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● Glands: PSA, PAP; basal layer: keratin 34betaE12
Negative stains
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Electron microscopy descriptions
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Electron microscopy images
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Molecular / cytogenetics description
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Molecular / cytogenetics images
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Differential Diagnosis
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● Post-surgical ingrowth of prostatic tissue
● Retrovesical prostatic tissue (Urol Int 2001;66:171)
Additional references
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End of Bladder > Congenital anomalies > Ectopic prostate
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