Breast nonmalignant
Benign tumors
Juvenile papillomatosis (swiss cheese disease)


Topic Completed: 1 August 2012

Revised: 10 September 2019

Copyright: 2002-2019, PathologyOutlines.com, Inc.

PubMed Search: juvenile papillomatosis

Monika Roychowdhury, M.D.
Page views in 2019 to date: 794
Cite this page: Roychowdhury M. Juvenile papillomatosis (swiss cheese disease). PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/breastjuvenilepapillomatosis.html. Accessed November 12th, 2019.
Definition / general
  • Grossly distinct multinodular mass with clustering of cystic formations resembling swiss cheese, composed of epithelial proliferation and clustered cysts
  • First described by Rosen in 1980 (Am J Surg Pathol 1980;4:3)
Terminology
  • Not part of WHO breast classification
Epidemiology
  • Mean age 19 years
  • 2 / 3 are less than age 20 years
Clinical features
Case reports
Clinical images

Contributed by Dr. Mark R. Wick

Mammogram

Gross description
  • Localized multinodular mass with clustering of cystic formations resembling swiss cheese
Gross images

Contributed by Dr. Mark R. Wick

Juvenile papillomatosis



Images hosted on other servers

Multiple cysts resembling swiss cheese

Microscopic (histologic) description
  • Florid epithelial hyperplasia and papillomatosis, cysts with foamy histiocytes and sclerosing adenosis
  • Variable apocrine metaplasia, atypia and necrosis
Microscopic (histologic) images

Contributed by Dr. Mark R. Wick

Juvenile papillomatosis



AFIP images

Multiple cystically dilated ducts

Hyperplastic epithelium in dilated duct

Intraductal epithelial proliferation with necrosis

Apocrine metaplasia
of hyperplastic
intraductal
epithelium


Hyperplastic epithelium and foam cells

With sclerosing adenosis
and apocrine metaplasia
adjacent to cystically
dilated ducts

Multiple small intraductal papillomas in 15 year old girl

    

High power shows hyperplastic
intraductal epithelium, myoepithelial
cells are associated with the
delicate fibrovascular stalks



Images hosted on other servers
Missing Image

Various images

Clustered cysts

Epithelial hyperplasia

Cytology description
  • Difficult to diagnose
  • Cystic fluid, but mass persists after aspiration
  • Sheets of hyperplastic breast epithelium with areas resembling fibroadenoma, macrophages and apocrine cells (Diagn Cytopathol 1993;9:457)
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