Breast

Other nonneoplastic

Juvenile papillomatosis



Topic Completed: 1 August 2012

Minor changes: 14 May 2021

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PubMed Search: juvenile papillomatosis

Monika Roychowdhury, M.D.
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Cite this page: Roychowdhury M. Juvenile papillomatosis. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/breastjuvenilepapillomatosis.html. Accessed October 25th, 2021.
Definition / general
  • Grossly distinct multinodular mass with clustering of cystic formations resembling swiss cheese, composed of epithelial proliferation and clustered cysts
  • First described by Rosen in 1980 (Am J Surg Pathol 1980;4:3)
Terminology
  • Not part of WHO breast classification
Epidemiology
  • Mean age 19 years
  • 2 / 3 are less than age 20 years
Clinical features
Case reports
Clinical images

Contributed by Mark R. Wick, M.D.

Mammogram

Gross description
  • Localized multinodular mass with clustering of cystic formations resembling swiss cheese
Gross images

Contributed by Mark R. Wick, M.D.

Juvenile papillomatosis

Microscopic (histologic) description
  • Florid epithelial hyperplasia and papillomatosis, cysts with foamy histiocytes and sclerosing adenosis
  • Variable apocrine metaplasia, atypia and necrosis
Microscopic (histologic) images

Contributed by Mark R. Wick, M.D.

Juvenile papillomatosis



AFIP images

Multiple cystically dilated ducts

Hyperplastic epithelium in dilated duct

Intraductal epithelial proliferation with necrosis

Apocrine metaplasia
of hyperplastic
intraductal
epithelium


Hyperplastic epithelium and foam cells

With sclerosing adenosis
and apocrine metaplasia
adjacent to cystically
dilated ducts

Multiple small intraductal papillomas in 15 year old girl

    

High power shows hyperplastic
intraductal epithelium, myoepithelial
cells are associated with the
delicate fibrovascular stalks

Cytology description
  • Difficult to diagnose
  • Cystic fluid, but mass persists after aspiration
  • Sheets of hyperplastic breast epithelium with areas resembling fibroadenoma, macrophages and apocrine cells (Diagn Cytopathol 1993;9:457)
Cytology images

Contributed by Areej M. Al Nemer, M.D.
Suspicious nipple discharge

Suspicious nipple discharge

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