CD Markers
CD10



Topic Completed: 1 September 2013

Revised: 24 July 2019

Revised: 13 December 2018, last major update September 2013

Copyright: (c) 2002-2018, PathologyOutlines.com, Inc.

PubMed Search: CD10[title]


Nat Pernick, M.D.
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Cite this page: Pernick N. CD10. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd10.html. Accessed November 18th, 2019.
Definition / general
  • Cell membrane metallopeptidase widely distributed in hematopoietic cells and their neoplasms
  • Important in diagnosis of preB-ALL (OMIM #120520)
  • Useful in diagnosis of other entities (see below), but must be used with caution, as staining is nonspecific
Terminology
  • Also called Common Acute Lymphoblastic Leukemia Antigen (CALLA), neutral endopeptidase 24.11, neprilysin, enkephalinase
Pathophysiology
  • 90-110 kDa cell membrane metallopeptidase at 3q21-27 which inactivates bioactive peptides, including bombesin
  • In epithelial cells, CD10 loss from methylation leads to increased cell migration, cell growth and cell survival, contributing to neoplastic development and progression (J Pediatr Hematol Oncol 2010;32:2)
Uses by pathologists
  • Apical surface staining only: well differentiated carcinoma of colon, pancreas, prostate (Am J Clin Pathol 2000;113:374)
  • Diffuse cytoplasmic or membranous / Golgi staining pattern: adenocarcinoma (poorly differentiated), endometrial stromal sarcoma, melanoma, renal cell carcinoma, urothelial carcinoma

Acute lymphoblastic leukemia (ALL):
  • One of first markers to identify leukemic cells in children (hence its name)
  • Found on ALL cells which derive from pre-B lymphocytes

Bladder:
Breast:
Ectopic prostate:
Endometrial stromal tumors:
Endometriosis:
Gynecologic tumors:
  • Mesonephric remnants and tumors are CD10+
  • CD10 differentiates metastatic renal cell carcinoma (CD10+, Am J Surg Pathol 2003;27:178) from primary clear cell carcinoma (CD10-)

Hepatocellular carcinoma vs. non-hepatocellular carcinoma:
Kidney
Lymphoma: angioimmunoblastic T cell (AITL):
Lymphoma: Burkitt:
Lymphoma: diffuse large B cell:
Lymphoma: follicular:
Microvillous inclusion disease:
Pancreas:
  • Confirm diagnosis of solid and papillary neoplasm (CD10+, Am J Surg Pathol 2000;24:1361)
  • Differentiates mucinous cystic neoplasms (CD10+ / CK20+) from intraductal papillary mucinous neoplasm of branch duct type (CD10- / CK20-, Pancreas 2009;38:558)

Skin tumors:
  • Staining patterns may differentiate basal cell carcinoma-epithelial staining, trichoblastoma-peritumoral stromal staining (Int J Dermatol 2009;48:713), squamous cell carcinoma-strong stromal staining (Iran J Med Sci 2013;38:100)
  • Differentiates atypical fibroxanthoma (diffuse membranocytoplasmic staining) from spindle cell melanoma and sarcomatoid squamous cell carcinoma (CD10-, J Cutan Pathol 2010;37:744)

Vascular tumors:
Microscopic (histologic) images
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Bladder:
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Noninvasive and invasive urothelial carcinoma

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Bladder urothelial carcinoma



Breast:
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Myoepithelium (fig B, F)

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Normal and DCIS

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DCIS

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Stromal staining in invasive ductal carcinoma

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Malignant phyllodes tumor

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Adenosis (fig B)



Kidney:
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Kidney hemangioblastoma (fig D)



Leukemia / lymphoma:
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Diffuse large B cell lymphoma

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Pre-T ALL



Lung:
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COPD



Lymph node:
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Metastatic prostate carcinoma

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Metastatic seminoma



Pleura:
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Epithelioid hemangioendothelioma



Skin:
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Basal cell carcinoma (fig B)

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Squamous cell carcinoma (fig B)

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Trichoepithelioma



Small intestine:
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Microvillous inclusion disease



Uterus - benign:
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Endometriosis

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CD10- stromal cells



Uterus - endometrial stromal sarcoma:
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Extrauterine (fig 4, inset ER)

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Myxoid-fibrous (fig 4)

Positive staining - normal
    Hematopoietic cells:
    • PreB cells, preT cells; some T cells, follicular center (germinal center) cells, granulocytes

    Other cells:
    • Adrenal cortex, brain, choroid plexus
    • Endometrial stroma, endothelial cells (some, Hypertension 1995;26:230), fibroblasts
    • GU (male) epithelium, hepatocytes, kidney microvilli
    • Liver, mesonephric remnants, myoepithelial cells (breast, Mod Pathol 2002;15:397, J Clin Pathol 2004;57:625)
    • Ovary, placenta (cytotrophoblast, intermediate trophoblast, syncytiotrophoblast), prostate basal and secretory cells
    • Small intestine (linear brush border staining, variable loss with active enteritis, Mod Pathol 2011;24:1627), Wolffian (but not Müllerian) type epithelium
Positive staining - disease
Negative staining
    Leukemia / lymphomas:
    • AML, Burkitt-like, CLL, EBV+ lymphoproliferative disorders
    • Lymphoplasmacytic, mantle cell, marginal zone, pyothorax associated

    Other:
    • Atypical polypoid adenomyoma (stromal cells), clear cell carcinoma of female genital tract, CNS hemangioblastoma
    • Colon (normal, diseased), erythroid and myeloid precursors, prostatic high grade PIN and basal cell hyperplasia (Hum Pathol 2003;34:450), prostate adenocarcinoma (all Gleason patterns 2 and 3, some 4 and 5)
Flow cytometry images

Images hosted on other servers:

CD10+ vs. CD10- diffuse large B cell lymphoma

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