Reviewers: Nat Pernick, M.D., (see Reviewers page)
Revised: 6 January 2011, last major update January 2011
Copyright: (c) 2002-2011, PathologyOutlines.com, Inc.
● Forms the beta 2 chain of CD11a-d to create a leukocyte adhesion molecule (see below)
● Gene is designated ITGB2 (integrin beta 2)
● Combines with alpha L chain (CD11a) to form the integrin LFA-1
● Combines with the alpha M chain (CD11b) to form the integrin Mac-1 (macrophage antigen 1, complement receptor 3)
● Combines with the alpha X chain (CD11c) to form completement receptor 4
● Also combines with the alpha D chain (CD11d)
● Important for adhesion and signaling in the hematopoietic system (see CD11a-c); also for phagocytosis
(J Immunol 2002;169:2003)
● Deficiency of the CD18 component (leukocyte adhesion deficiency type 1) is a rare, inherited disorder, causing severe leukocytosis and recurrent severe bacterial infections early in life of skin and mucosal surfaces, possibly fatal, due to defective white blood cell adherence, chemotaxis, phagocytosis and bacterial killing (OMIM 116920, J Clin Immunol 2010;30:756)
● Note: leukocyte adhesion deficiency type 2 is due to a deficiency in CD15s
● CD11b/CD18 is receptor for Bordetella pertussis adhesin filamentous hemagglutinin (FHA) and for the adenylate cyclase toxin (ACT), which blocks neutrophil function (Infect Immun 2005;73:7317, J Exp Med 2001;193:1035)
● CD11b/CD18 induces neutrophilic response leading to killing of Steptococcus pyogenes (Eur J Immunol 2005;35:1472)
● No significant clinical use by pathologists
Positive staining - normal
● Neutrophils, macrophages, monocytes, NK cells, basophils
● MIM 600065
End of CD Markers > CD18
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