CD Markers

Author: Nat Pernick, M.D. (see Authors page)

Revised: 6 November 2015, last major update February 2002

Copyright: (c) 2002-2015,, Inc.

Definition / General
  • Also called Leu7, beta-1,3-glucuronyltransferase 1 and glucuronosyltransferase P
  • Glycoprotein with cell adhesion functions
  • May define a phenotype associated with replicative senescence in HIV specific CD8+ T cells (Blood 2003;101:2711)
  • References: OMIM #151290
Case Reports
Uses by Pathologists
  • Marker of NK cells and neuroendocrine tumors, helps distinguish high grade prostatic adenocarcinoma (CD57+) from high grade urothelial carcinoma (CD57-)
Micro Images

Images hosted on other servers:

Metanephric adenoma (fig E)

Large granular lymphocytic leukemia (fig 11)

Papillary carcinoma of thyroid (fig B)

"Atypical cytology, cannot exclude papillary carcinoma"
(fig B)

Positive Staining - Normal
  • NK subset, T cell subset, neuroectodermal tissue, retina, brain, prostate and renal proximal tubules
Positive Staining - Disease
Positive staining - Tumors
Negative Staining
  • B cells, monocytes, red blood cells and platelets; NK/T cell lymphoma-nasal type, Wilm’s tumor