Reviewer: Nat Pernick, M.D. (see Reviewers page)
Revised: 10 September 2013, last major update February 2002
Copyright: (c) 2002-2013, PathologyOutlines.com, Inc.
- Also called Leu7, beta-1,3-glucuronyltransferase 1 and glucuronosyltransferase P
- Glycoprotein with cell adhesion functions
- May define a phenotype associated with replicative senescence in HIV specific CD8+ T cells (Blood 2003;101:2711)
- References: OMIM #151290
Uses by pathologists
- Marker of NK cells and neuroendocrine tumors, helps distinguish high grade prostatic adenocarcinoma (CD57+) from high grade urothelial carcinoma (CD57-)
Metanephric adenoma (fig E)
Large granular lymphocytic leukemia (fig 11)
Papillary carcinoma of thyroid (fig B)
"Atypical cytology, cannot exclude papillary carcinoma"
Positive staining - normal
- NK subset, T cell subset, neuroectodermal tissue, retina, brain, prostate and renal proximal tubules
Positive staining - disease
Positive staining - tumors
- Other: carcinoid tumors, desmoplastic nested spindle cell tumor of liver (Am J Surg Pathol 2005;29:1), desmoplastic small round cell tumor (Am J Surg Pathol 1998;22:1314), germ cell tumor (embryonal carcinoma, seminoma), mesenchymal chondrosarcoma, metanephric adenoma (Am J Surg Pathol 2001;25:1290), neuroendocrine carcinoma of prostate (Am J Surg Pathol 2006;30:684) and other sites, PNET, prostatic adenocarcinoma, renal carcinoid, renal clear cell carcinoma (some), small cell carcinoma of lung and other sites, spindle cell thymoma (Am J Surg Pathol 2001;25:111), synovial sarcoma and thyroid papillary carcinoma (Cancer 2006;108:331)
- B cells, monocytes, red blood cells and platelets; NK/T cell lymphoma-nasal type, Wilm’s tumor
End of CD Markers > CD57
This information is intended for physicians and related personnel, who understand that medical information is often imperfect, and must be interpreted in the context of a patient's clinical data using reasonable medical judgment. This website should not be used as a substitute for the advice of a licensed physician.
All information on this website is protected by copyright of PathologyOutlines.com, Inc. Information from third parties may also be protected by copyright. Please contact us at copyrightPathOut@gmail.com
with any questions (click here for other