CD Markers
CD57



Topic Completed: 1 February 2011

Revised: 21 August 2019

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD57[title] CD Marker

Nat Pernick, M.D.
Page views in 2018: 3,898
Page views in 2019 to date: 4,419
Cite this page: Pernick N. CD57. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd57.html. Accessed December 14th, 2019.
Definition / general
  • Also called Leu7, beta-1,3-glucuronyltransferase 1 and glucuronosyltransferase P
  • Glycoprotein with cell adhesion functions
  • May define a phenotype associated with replicative senescence in HIV specific CD8+ T cells (Blood 2003;101:2711)
  • References: OMIM #151290
Case reports
Uses by pathologists
  • Marker of NK cells and neuroendocrine tumors, helps distinguish high grade prostatic adenocarcinoma (CD57+) from high grade urothelial carcinoma (CD57-)
Microscopic (histologic) images

Images hosted on other servers:
Missing Image

Metanephric adenoma (fig E)

Missing Image

Large granular lymphocytic leukemia (fig 11)

Missing Image

Papillary carcinoma of thyroid (fig B)

Missing Image

"Atypical cytology, cannot exclude papillary carcinoma"
(fig B)

Positive staining - normal
  • NK subset, T cell subset, neuroectodermal tissue, retina, brain, prostate and renal proximal tubules
Positive staining - disease
Positive staining - tumors
Negative staining
  • B cells, monocytes, red blood cells and platelets; NK/T cell lymphoma-nasal type, Wilm’s tumor
Back to top