CD Markers

Topic Completed: 1 February 2011

Revised: 14 December 2018, last major update February 2002

Copyright: (c) 2002-2015,, Inc.

Nat Pernick, M.D.
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Cite this page: Pernick N. CD57. website. Accessed August 20th, 2019.
Definition / general
  • Also called Leu7, beta-1,3-glucuronyltransferase 1 and glucuronosyltransferase P
  • Glycoprotein with cell adhesion functions
  • May define a phenotype associated with replicative senescence in HIV specific CD8+ T cells (Blood 2003;101:2711)
  • References: OMIM #151290
Case reports
Uses by pathologists
  • Marker of NK cells and neuroendocrine tumors, helps distinguish high grade prostatic adenocarcinoma (CD57+) from high grade urothelial carcinoma (CD57-)
Microscopic (histologic) images

Images hosted on other servers:

Metanephric adenoma (fig E)

Large granular lymphocytic leukemia (fig 11)

Papillary carcinoma of thyroid (fig B)

"Atypical cytology, cannot exclude papillary carcinoma"
(fig B)

Positive staining - normal
  • NK subset, T cell subset, neuroectodermal tissue, retina, brain, prostate and renal proximal tubules
Positive staining - disease
Positive staining - tumors
Negative staining
  • B cells, monocytes, red blood cells and platelets; NK/T cell lymphoma-nasal type, Wilm’s tumor
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