CD Markers
CD99

Author: Nat Pernick, M.D. (see Authors page)

Revised: 10 November 2015, last major update February 2002

Copyright: (c) 2002-2015, PathologyOutlines.com, Inc.

PubMed Search: CD99 [title]

Cite this page: CD99. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cdmarkerscd99.html. Accessed December 11th, 2016.
Definition / General
  • Also called MIC2, O13, T cell surface glycoprotein E2
  • Encoded by pseudoautosomal gene on short arms of X and Y
  • Part of Xg blood group system (NCBI)
  • Functions: cell surface glycoprotein involved with
    1. Differentiation of primitive neuroectodermal cells (Exp Mol Med 2003;35:438)
    2. Apoptosis of T cells (FEBS Lett 2003;554:478)
    3. T cell adhesion
    4. Migration of leukocytes
    5. In Ewing/PNET, may promote growth and migration of tumor cells via downregulation of KCMF1 (potassium channel modulatory factor), a possible metastasis suppressor gene (Oncogene 2006;25:2795)
  • Associated with EWS-FLI1 fusion transcript, t(11;22)(q24;q12), causing FLI-1 protein overexpression
Interpretation
  • Distinct membranous staining for Ewing/PNET; cytoplasmic for other tumors
Uses by Pathologists
Micro Images

Images hosted on Other servers of Ewing/PNET:

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Bone

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Cavernous sinus

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Cervix

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Gallbladder

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Lung


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Prostate

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Stomach

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Site unknown



Images hosted on Other servers of leukemia / lymphoma:

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AML

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AML-M0

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AML-M3



Other images on Other servers:

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Adult granulosa cell tumor, ovary

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Ectopic hamartomatous thymoma

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GIST vs. solitary fibrous tumor

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Solitary fibrous tumor, larynx

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Solitary fibrous tumor, ear

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Spindle cell epithelioma of vagina


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Synovial sarcoma, lung



Nature images:

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PNET, dura

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Chloroma



Positive Staining - Normal
Positive Staining - Disease
Negative Staining
Additional References