Cervix
Sarcoma / lymphoma / other
Lymphoma

Author: Branko Perunovic, M.D. (see Authors page)

Revised: 27 April 2017, last major update May 2007

Copyright: (c) 2007-2017, PathologyOutlines.com, Inc.

PubMed Search: Lymphoma cervix

Cite this page: Lymphoma. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/cervixlymphoma.html. Accessed July 22nd, 2017.
Definition / general
  • Primaries are rare in cervix ( < 100 cases reported)
  • Mean age approximately 40 years; range 20's to 80's
  • Usually present with abnormal uterine or vaginal bleeding; may have negative cervical smear or be reported as SIL
  • Most cases present with stage IE disease (Am J Obstet Gynecol 2005;193:866)
  • Usually diffuse large B cell lymphoma or follicular lymphoma (Mod Pathol 2000;13:19)
  • 5 year survival: 83% in low stage tumors, 29% in high stage tumors
  • Should confirm with immunostains to rule out other unusual tumors and to classify
Case reports
Diffuse large B cell lymphoma:
Gross description
  • Diffuse enlargement of cervix (barrel shaped), or polypoid mass with fish flesh appearance
  • Soft, gray white
Microscopic (histologic) description
  • Tumor cells infiltrate stroma without destroying glandular or squamous epithelium
Microscopic (histologic) images

Images hosted on other servers:

H&E and CD20


Marginal zone lymphoma

High grade MALT presenting as endocervical polyp

NK lymphoma

Differential diagnosis