CNS tumor
Pineal tumors

Author: Nat Pernick, M.D. (see Authors page)

Revised: 5 September 2017, last major update January 2006

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Pineocytoma [title]

Cite this page: Pernick, N. Pineocytoma. website. Accessed June 20th, 2018.
Definition / general
  • Grade I of IV
  • Mostly adults age 25 - 35 years
  • Slow growing
  • Average survival 7 years
Gross description
  • Well circumscribed, gray, hemorrhagic
Microscopic (histologic) description
  • Similar to normal pineal glands well differentiated cells but hypercellular
  • Fibrovascular stroma highlights expansive lobules of tumor cells with uniform round nuclei
  • Pinocytomatous rosettes (large, loose, Homer Wright-like rosettes with central fibrillar zones surrounded by neoplastic cells with round nuclei)
  • May have features of neuronal differentiation (ganglion cells)
  • Noninfiltrative, no / rare mitotic figures, no necrosis, no / minimal atypia
Microscopic (histologic) images

Images hosted on other servers:

Small cells and pineocytomatous rosettes

Larger cells resembling pineocytes

Small amounts of an eosinophilic matrix



Bodian silver impregnation

Chromogranin A

Differential diagnosis