CNS tumor
Pineal tumors

Topic Completed: 1 January 2006

Revised: 2 January 2018, last major update January 2006

Copyright: (c) 2002-2017,, Inc.

PubMed Search: Pineocytoma [title]

Nat Pernick, M.D.
Page views in 2019: 2,183
Page views in 2020 to date: 1,119
Cite this page: Pernick N. Pineocytoma. website. Accessed July 13th, 2020.
Definition / general
  • Grade I of IV
  • Mostly adults age 25 - 35 years
  • Slow growing
  • Average survival 7 years
Gross description
  • Well circumscribed, gray, hemorrhagic
Microscopic (histologic) description
  • Similar to normal pineal glands well differentiated cells but hypercellular
  • Fibrovascular stroma highlights expansive lobules of tumor cells with uniform round nuclei
  • Pinocytomatous rosettes (large, loose, Homer Wright-like rosettes with central fibrillar zones surrounded by neoplastic cells with round nuclei)
  • May have features of neuronal differentiation (ganglion cells)
  • Noninfiltrative, no / rare mitotic figures, no necrosis, no / minimal atypia
Microscopic (histologic) images

Images hosted on other servers:

Small cells and pineocytomatous rosettes

Larger cells resembling pineocytes

Small amounts of an eosinophilic matrix



Bodian silver impregnation

Chromogranin A

Differential diagnosis
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