Colon non tumor
Colitis (non-infectious)
NSAID associated colitis

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 27 December 2016, last major update May 2013

Copyright: (c) 2003-2016,, Inc.

PubMed Search: NSAID associated colitis
Cite this page: NSAID associated colitis. website. Accessed April 27th, 2017.
Definition / General
  • Associated with bleeding, diarrhea, abdominal pain, although usual side effects are subclinical (Am J Med Sci 2009;338:96)
Clinical Features
Case Reports
Micro Description
  • Usually mixed inflammatory infiltrate, but may be predominantly neutrophilic or lymphocytic (Am J Clin Pathol 1998;110:622, Adv Anat Pathol 1999;6:213)
  • Often erosions, crypt architectural disarray; no granulomas
  • Incidental chronic colitis: cecal-based chronic colitis associated with frequent NSAID use; basal plasmacytosis (94%) or crypt architectural distortion (94%) often disappears after NSAID withdrawal (Am J Surg Pathol 2010;34:463)
Micro Images

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Ulcer post-NSAID therapy