Colon nontumor
Colitis (noninfectious)
NSAID associated colitis

Author: Hanni Gulwani, M.D. (see Authors page)

Revised: 16 July 2018, last major update May 2013

Copyright: (c) 2003-2018,, Inc.

PubMed Search: NSAID associated colitis
Cite this page: Gulwani, H. NSAID associated colitis. website. Accessed October 19th, 2018.
Definition / general
  • Associated with bleeding, diarrhea, abdominal pain, although usual side effects are subclinical (Am J Med Sci 2009;338:96)
Clinical features
Case reports
Microscopic (histologic) description
  • Usually mixed inflammatory infiltrate but may be predominantly neutrophilic or lymphocytic (Am J Clin Pathol 1998;110:622, Adv Anat Pathol 1999;6:213)
  • Often erosions, crypt architectural disarray; no granulomas
  • Incidental chronic colitis: cecal based chronic colitis associated with frequent NSAID use; basal plasmacytosis (94%) or crypt architectural distortion (94%) often disappears after NSAID withdrawal (Am J Surg Pathol 2010;34:463)
Microscopic (histologic) images

Images hosted on other servers:
Missing Image

Ulcer post-NSAID therapy