Table of ContentsDefinition / general | Clinical features | Case reports | Treatment | Microscopic (histologic) description | Microscopic (histologic) images | Differential diagnosis
Cite this page: Gulwani H. NSAID associated colitis. PathologyOutlines.com website. http://www.pathologyoutlines.com/topic/colonnsaid.html. Accessed May 30th, 2020.
Definition / general
- Associated with bleeding, diarrhea, abdominal pain, although usual side effects are subclinical (Am J Med Sci 2009;338:96)
Microscopic (histologic) description
- Usually mixed inflammatory infiltrate but may be predominantly neutrophilic or lymphocytic (Am J Clin Pathol 1998;110:622, Adv Anat Pathol 1999;6:213)
- Often erosions, crypt architectural disarray; no granulomas
- Incidental chronic colitis: cecal based chronic colitis associated with frequent NSAID use; basal plasmacytosis (94%) or crypt architectural distortion (94%) often disappears after NSAID withdrawal (Am J Surg Pathol 2010;34:463)